2-Methyl-5,6,7,8,11,11-hexachlor-5,8-methylen-1,2,3,4,5,8,9,10-octahydro-naphthalin | 92317-22-1

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 乙烯基卤化物
• 英文名称: 2-Methyl-5,6,7,8,11,11-hexachlor-5,8-methylen-1,2,3,4,5,8,9,10-octahydro-naphthalin
• 英文别名: (+/-)-1,2,3,4,9,9-hexachloro-6ξ-methyl-(4ac,8ac)-1,4,4a,5,6,7,8,8a-octahydro-1r,4-methano-naphthalene；(+/-)-1,2,3,4,9,9-Hexachlor-6ξ-methyl-(4ac,8ac)-1,4,4a,5,6,7,8,8a-octahydro-1r,4-methano-naphthalin；(+/-)-1.2.3.4.9.9-Hexachlor-6ξ-methyl-(4arH.8acH)-1.4.4a.5.6.7.8.8a-octahydro-1c.4c-methano-naphthalin
• CAS: 92317-22-1
• 化学式: C₁₂H₁₂Cl₆
• 分子量: 368.945
• InChiKey: VILCIRMYBBJHND-VTGRUSJYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.88
• 重原子数：
  18.0
• 可旋转键数：
  0.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为产物：
  描述：

  4-甲基-1-环己烯 、 六氯环戊二烯 生成 2-Methyl-5,6,7,8,11,11-hexachlor-5,8-methylen-1,2,3,4,5,8,9,10-octahydro-naphthalin
  参考文献：
  名称：

  Pre-mRNA Splicing Imprints mRNA in the Nucleus with a Novel RNA-Binding Protein that Persists in the Cytoplasm

  摘要：

  We describe a novel RNA binding protein, Y14, a predominantly nuclear nucleocytoplasmic shuttling protein. Interestingly, Y14 associates preferentially with mRNAs produced by splicing but not with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Y14 associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs. Splicing of a single intron is sufficient for Y14 association. Y14-containing nuclear complexes are different from general hnRNP complexes. They contain hnRNP proteins and several unique proteins including the mRNA export factor TAP. Thus, Y14 defines novel intermediates in the pathway of gene expression, postsplicing nuclear preexport mRNPs, and newly exported cytoplasmic mRNPs, whose composition is established by splicing. These findings suggest that pre-mRNA splicing imprints mRNA with a unique set of proteins that persists in the cytoplasm and thereby communicates the history of the transcript.

  DOI：

  10.1016/s1097-2765(00)00065-4

文献信息

• Reactions of Monoölefins and Hexachlorocyclopentadiene
  作者：Ellis K. Fields

  DOI：10.1021/ja01639a034

  日期：1954.5