2-乙基-1-甲氧基-4-甲基苯 | 79744-78-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 2-乙基-1-甲氧基-4-甲基苯
• 英文名称: 2-ethyl-4-methylphenyl methyl ether
• 英文别名: 2-ethyl-1-methoxy-4-methyl-benzene；2-ethyl-4-methyl-anisole；2-Aethyl-4-methyl-anisol；4-Methoxy-1-methyl-3-aethyl-benzol；2-Ethyl-4-methylanisole；2-ethyl-1-methoxy-4-methylbenzene
• CAS: 79744-78-8
• 化学式: C₁₀H₁₄O
• 分子量: 150.221
• InChiKey: NJTCSGOITDNDFY-UHFFFAOYSA-N

物化性质

• 沸点：
  206-208 °C
• 密度：
  0.924±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-乙基-1-甲氧基-4-甲基苯 在 盐酸 、 二硫化碳 、 三氯化铝 、 amalgamated zinc 作用下， 生成 2,5-diethyl-4-methyl-anisole
  参考文献：
  名称：

  v. Auwers; Mauss, Chemische Berichte, 1928, vol. 61, p. 1502

  摘要：

  DOI：
• 作为产物：
  描述：

  2-羟基-5-甲基苯乙酮 在 盐酸 、 amalgamated zinc 作用下， 生成 2-乙基-1-甲氧基-4-甲基苯
  参考文献：
  名称：

  Fischer, Alfred; Henderson, George N., Canadian Journal of Chemistry, 1981, vol. 59, p. 2314 - 2327

  摘要：

  DOI：

文献信息

• [EN] 2, 5-DIAMINO-SUBSTITUTED PYRIDO [4, 3-D] PYRIMIDINES AS AUTOTAXIN INHIBITORS AGAINST CANCER<br/>[FR] PYRIDO[4,3-D]PYRIMIDINES 2,5-DIAMINO-SUBSTITUÉES EN TANT QU'INHIBITEURS D'AUTOTAXINE CONTRE LE CANCER
  申请人：MERCK PATENT GMBH

  公开号：WO2010063352A1

  公开（公告）日：2010-06-10

  The present invention relates to pyridopyrimidine derivatives according to formula (I), as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.

  本发明涉及按照式(I)的吡啶吡嘧啶衍生物，作为自体毒素抑制剂，并且利用这类化合物用于治疗和/或预防由增加的溶磷脂酸水平和/或自体毒素的激活引起、介导和/或传播的生理和/或病理条件，特别是不同癌症。
• Novel Pyrimidine- And Triazine-Hepcidine Antagonists
  申请人：Dürrenberger Franz

  公开号：US20120202806A1

  公开（公告）日：2012-08-09

  The present invention relates to new hepcidin antagonists, pharmaceutical compositions containing them and the use thereof as a drug, in particular for the treatment of iron metabolism disorders such as, in particular, iron deficiency diseases and anaemia, in particular anaemia associated with chronic inflammatory disease (ACD: anaemia of chronic disease and AI: anaemia of inflammation).

  本发明涉及新的肝铁蛋白拮抗剂，包含它们的药物组合物以及将其用作药物的用途，特别是用于治疗铁代谢紊乱，如特别是铁缺乏病和贫血，特别是与慢性炎症性疾病相关的贫血（ACD：慢性疾病性贫血和AI：炎症性贫血）。
• Benzodioxane and benzodioxolane derivatives and uses thereof
  申请人：Zhou Dahui

  公开号：US20060241172A1

  公开（公告）日：2006-10-26

  Compounds of formula I or pharmaceutically acceptable salts thereof are provided: wherein each of R 1 , R 2 , R 3 , R 4 , y, n, m, and Ar are as defined, and described in classes and subclasses herein, which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.

  提供了化学式I或其药用可接受盐的化合物：其中R1、R2、R3、R4、y、n、m和Ar中的每一个如所定义，并在此处描述的类和亚类中，它们是大脑5-羟色胺受体2C亚型的激动剂或部分激动剂。这些化合物和含有这些化合物的组合物可用于治疗多种中枢神经系统疾病，如精神分裂症。
• Thiazolyl mglur5 antagonists and methods for their use
  申请人：Cosford Nicholas D.

  公开号：US20090203903A1

  公开（公告）日：2009-08-13

  The identification of a unique series of compounds which possesses special advantages in terms of drug-like properties due to their possessing advantageous properties in terms of potency and/or pharmacokinetic and/or selectivity and/or in vivo receptor occupancy properties. Specifically, the selection of a 1,3-thiazol-2-yl ring member linked by an ethynylene to the 3 position of a pyridyl ring or the 5 position of a pyrimidinyl ring, wherein the ring is substituted with selected substituents, results in a compound having superior drug-like properties. The invention includes pharmaceutically acceptable salt forms of these heterocyclic compounds, in particular chloride salts and trifluoroacetate salts.

  一系列独特化合物的鉴定，由于它们在药物样性方面具有优势特性，包括在效力、药代动力学、选择性和体内受体占有性质方面具有优势特性。具体来说，选择一个由乙炔基连接到吡啶环的3位或嘧啶环的5位的1,3-噻唑-2-基环成员，其中环被选定取代基取代，将导致一种具有优越药物样性的化合物。该发明包括这些杂环化合物的药用盐形式，特别是氯化盐和三氟乙酸盐。
• CATALYSTS AND METHODS FOR POLYMER SYNTHESIS
  申请人：NOVOMER, INC.

  公开号：US20130144032A1

  公开（公告）日：2013-06-06

  The present invention provides unimolecular metal complexes having increased activity in the copolymerization of carbon dioxide and epoxides. Also provided are methods of using such metal complexes in the synthesis of polymers. According to one aspect, the present invention provides metal complexes comprising an activating species with co-catalytic activity tethered to a multidentate ligand that is coordinated to the active metal center of the complex.

  本发明提供了在二氧化碳和环氧化物的共聚合中具有增强活性的单分子金属配合物。还提供了使用这种金属配合物在合成聚合物中的方法。根据一个方面，本发明提供了包括与具有共催化活性的活化物种相耦合的多齿配体的金属配合物，该多齿配体与复合物的活性金属中心配位。

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