A stereoselective synthesis of asymmetrically substituted calix[4]arenecarbamates
作者:Vyacheslav I. Boyko、Alexander Shivanyuk、Volodymyr V. Pyrozhenko、Roman I. Zubatyuk、Oleg V. Shishkin、Vitaly I. Kalchenko
DOI:10.1016/j.tetlet.2006.08.095
日期:2006.10
Calix[4]arenes bearing a methoxy and an R or S alpha-phenylethylacetamido group at the narrow rim of macrocycles are stereoselectively acylated with 1 equiv of trichloroacetyl isocyanate to give chiral asymmetrically substituted calix[4]arenecarbamates in preparative yields and high diastereomeric excess. (c) 2006 Elsevier Ltd. All rights reserved.