5-[[Tert-butyl(diphenyl)silyl]oxymethyl]-2-iodo-4-(2-methoxyethoxymethoxy)phenol | 195601-84-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-[[Tert-butyl(diphenyl)silyl]oxymethyl]-2-iodo-4-(2-methoxyethoxymethoxy)phenol
• CAS: 195601-84-4
• 化学式: C₂₇H₃₃IO₅Si
• 分子量: 592.546
• InChiKey: RHDUIRDNGNHNPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.07
• 重原子数：
  34
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  57.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-[[Tert-butyl(diphenyl)silyl]oxymethyl]-2-iodo-4-(2-methoxyethoxymethoxy)phenol 在 N,N-二甲基丙烯基脲 、 N-溴代丁二酰亚胺(NBS) 、 四(三苯基膦)钯 、 四丁基氟化铵 、 sodium hydride 、 溶剂黄146 、 1,2-二溴乙烷 、 三苯基膦 、 锌 作用下， 以 四氢呋喃 为溶剂， 反应 11.0h， 生成 [3-[[4-(Bromomethyl)-2-methoxy-5-(2-methoxyethoxymethoxy)phenyl]methyl]-4-(cyanomethoxy)phenyl] benzoate
  参考文献：
  名称：

  Anionic- and Lipophilic-Mediated Surface Binding Inhibitors of Human Leukocyte Elastase

  摘要：

  We report the synthesis of a series of diphenylmethane-based oligomers containing anionic and lipophilic functionalities that are potent inhibitors of human leukocyte elastase (HLE). The enzyme inhibition is regulated by the size of the oligomer, as well as, the number of charges. Lipophilicity is an important element in determining potency and specificity against other basic enzymes. Compounds whose scaffolds contain three phenoxyacetic acid groups and three alkyl ethers are competitive and specific inhibitors of HLE with K-i 20 nM. The mechanism of action of this class of compounds is believed to involve multidendate interactions with the surface of HLE near the active site which prevents substrate access to the catalytic site.

  DOI：

  10.1021/jm970251r
• 作为产物：
  描述：

  3-[[Tert-butyl(diphenyl)silyl]oxymethyl]-4-(2-methoxyethoxymethoxy)phenol 在 吗啉 、 N-Iodosuccinamide 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以81%的产率得到5-[[Tert-butyl(diphenyl)silyl]oxymethyl]-2-iodo-4-(2-methoxyethoxymethoxy)phenol
  参考文献：
  名称：

  Anionic- and Lipophilic-Mediated Surface Binding Inhibitors of Human Leukocyte Elastase

  摘要：

  We report the synthesis of a series of diphenylmethane-based oligomers containing anionic and lipophilic functionalities that are potent inhibitors of human leukocyte elastase (HLE). The enzyme inhibition is regulated by the size of the oligomer, as well as, the number of charges. Lipophilicity is an important element in determining potency and specificity against other basic enzymes. Compounds whose scaffolds contain three phenoxyacetic acid groups and three alkyl ethers are competitive and specific inhibitors of HLE with K-i 20 nM. The mechanism of action of this class of compounds is believed to involve multidendate interactions with the surface of HLE near the active site which prevents substrate access to the catalytic site.

  DOI：

  10.1021/jm970251r