alanyl-proline | 3918-95-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: alanyl-proline
• 英文别名: optically inactive 1-alanyl-proline；Opt.-inakt 1-Alanyl-prolin；1-(2-amino-propionyl)-pyrrolidine-2-carboxylic acid；alanylproline；1-(2-Ammoniopropanoyl)pyrrolidine-2-carboxylate；1-(2-azaniumylpropanoyl)pyrrolidine-2-carboxylate
• CAS: 3918-95-4；783284-98-0
• 化学式: C₈H₁₄N₂O₃
• 分子量: 186.211
• InChiKey: WPWUFUBLGADILS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.7
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  83.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  alanyl-proline 生成 (9CI)-六氢-3-甲基吡咯并[1,2-a]吡嗪-1,4-二酮
  参考文献：
  名称：

  SMITH, GRANT GILL;REDDY, G. SUDHAKAR G., J. CHEM. SOC. PERKIN TRANS.,(1988) N 2, 203-211

  摘要：

  DOI：
• 作为产物：
  描述：

  L-脯氨酸 在 ammonium hydroxide 、 sodium hydroxide 作用下， 生成 alanyl-proline
  参考文献：
  名称：

  Abderhalden; Zumstein, Fermentforschung, 1930, vol. 12, p. 1,10

  摘要：

  DOI：

文献信息

• Copper-Catalyzed Synthesis of Medium- and Large-Sized Nitrogen Heterocycles via N-Arylation of Phosphoramidates and Carbamates
  作者：Ting Yang、Changxue Lin、Hua Fu、Yuyang Jiang、Yufen Zhao

  DOI：10.1021/ol052126c

  日期：2005.10.1

  [reaction: see text] We have developed an efficient method for the preparation of medium- and large-sized nitrogen heterocycles via copper-catalyzed intramolecular N-arylation of phosphoramidates and carbamates. Introduction of the phosphoryl group or tert-butoxycarbonyl at N-termini can improve intramolecular cyclization under copper catalysis, and the phosphoryl and tert-butoxycarbonyl can easily

  [反应：见正文]我们已经开发了一种通过铜催化的氨基磷酸酯和氨基甲酸酯的分子内N-芳基化反应制备中型和大型氮杂环的有效方法。在N-末端引入磷酰基或叔丁氧羰基可以改善铜催化下的分子内环化，并且在温和的条件下可以容易地除去磷酰基和叔丁氧羰基。因此，该方便有效的方法适用于中，大型氮杂环的制备。
• [EN] AMINO ACID AND PEPTIDE CONJUGATES OF ARYLALKYLIC ACIDS FOR COSMETIC USE<br/>[FR] AMINOACIDE ET PEPTIDE CONJUGUÉS D'ACIDE ARYL-ALKYLE DESTINES A ETRE UTILISES EN COSMETIQUE
  申请人：DSM IP ASSETS BV

  公开号：WO2005092850A1

  公开（公告）日：2005-10-06

  The invention provides novel compounds of general formula (I), wherein R1, R2 and R3 are independently hydrogen, OR4, C1-C6 alkyl or C2-C6 alkenyl, R4 is hydrogen, C1-C6 alkyl or C2-C6 alkenyl, -N-(AA) represents the residue of an amino acid or of a peptide which is bonded over the N-terminus of the amino acid or the peptide and the peptide is composed of 2 to 6, that means 2, 3, 4, 5 or 6, amino acids, wherein the C-terminus of the amino acid or the peptide is optionally esterified with a C1-C16 hydrocarbon moiety and n is an integer of 1 to 5. The compounds are in particular useful for cosmetic applications.

  该发明提供了一般式（I）的新化合物，其中R1、R2和R3分别是氢、OR4、C1-C6烷基或C2-C6烯基，R4是氢、C1-C6烷基或C2-C6烯基，-N-(AA)代表氨基酸或肽的残基，该残基与氨基酸或肽的N-末端结合，该肽由2至6个氨基酸组成，即2、3、4、5或6个氨基酸，其中氨基酸或肽的C-末端可以选择性地与C1-C16烃基酯化，n是1至5的整数。这些化合物特别适用于化妆品应用。
• [EN] DIAGNOSTIC METHODS, THERAPEUTIC AGENTS AND USES THEREOF<br/>[FR] PROCÉDÉS DE DIAGNOSTIC, AGENT THÉRAPEUTIQUES ET LEURS UTILISATIONS
  申请人：METABOLON INC

  公开号：WO2018022866A1

  公开（公告）日：2018-02-01

  The present invention provides a compound of formula (I) or a salt thereof and their use as a biomarker in assessing or monitoring kidney function in a subject, determining predisposition to developing reduced kidney function, classifying a subject according to level of kidney function, diagnosing or monitoring chronic kidney disease. Compositions and method of making of the compound of formula (I) are also described.

  本发明提供了化合物(I)或其盐，并将其用作生物标志物来评估或监测受试者的肾功能，确定发展肾功能减退的易感性，根据肾功能水平对受试者进行分类，诊断或监测慢性肾病。还描述了化合物(I)的组成和制备方法。
• N-carboxyalkyl dipeptide derivatives and pharmaceutical compositions thereof
  申请人：BEECHAM GROUP PLC

  公开号：EP0060668A1

  公开（公告）日：1982-09-22

  Compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein m is 0 to 3; n is 1 to 5; R1 is hydrogen, or C1-6 alkyl; R2 is hydrogen, C1-4 alkyl, -(CH2)p-NH2 wherein p is 1 to 4, or -NHCOR, wherein R5 is C1-4 alkyl; R3 is hydrogen or C1-6 alkyl; R4 is C1-4 alkyl, C1-4 alkoxy, halogen or CF3; and X is CH2 or S. Having useful pharmacological activity, compositions containing them, and a process for their preparation.

  化学式（I）的化合物或其药学上可接受的盐，其中m为0至3；n为1至5；R1为氢或C1-6烷基；R2为氢、C1-4烷基、-(CH2)p-NH2，其中p为1至4，或-NHCOR，其中R5为C1-4烷基；R3为氢或C1-6烷基；R4为C1-4烷基、C1-4烷氧基、卤素或CF3；X为CH2或S。具有有用的药理活性，包含它们的组合物，以及它们的制备方法。
• Process for preparation of carboxyalkyldipeptide derivatives
  申请人：Merck & Co., Inc.

  公开号：EP0079521A1

  公开（公告）日：1983-05-25

  A process for the preparation of carboxyalkyldipeptide compounds of the Formula is described wherein R6 is hydroxy, loweralkoxy, or amino; R, R2 and R7 are hydrogen or loweralkyl; R3 is, e.g., hydrogen, or loweralkyl, R' is, e.g., hydrogen, or alkyl of from 1 to 20 carbon atoms, R4 is hydrogen or loweralkyl, R5 is, e.g., hydrogen, or loweralkyl, and, R4 and R5 may be connected together to form an alyklene bridge of from 2 to 4 carbon atoms. The process comprises reacting a compound of the Formula with a dipeptide (or protected dipeptide) of the Formula and an alkali metal cyanide or a trimethylsilycyanide, to form an amino nitrile compound of the Formula followed by hydrolysis. These compounds are useful as converting enzyme inhibitors and as antihypertensive agents.

  描述了一种制备Formula的羧基烷基二肽化合物的过程，其中R6为羟基、低烷氧基或氨基；R、R2和R7为氢或低烷基；R3为氢、低烷基等；R'为氢、1-20碳原子的烷基等；R4为氢或低烷基；R5为氢、低烷基等，R4和R5可以连接在一起形成2-4个碳原子的烷基桥。该过程包括将Formula的化合物与Formula的二肽（或保护的二肽）和碱金属氰化物或三甲基硅氰化物反应，形成Formula的氨基腈化合物，然后进行水解。这些化合物可用作转化酶抑制剂和降压剂。