(3S,4R)-3-amino-4-[2-(furan-2-yl)ethyl]azetidin-2-one | 110289-29-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: (3S,4R)-3-amino-4-[2-(furan-2-yl)ethyl]azetidin-2-one
• 英文别名: (3S,4R)-3-amino-4-[2-(2-furyl)ethyl]azetidin-2-one
• CAS: 110289-29-7
• 化学式: C₉H₁₂N₂O₂
• 分子量: 180.206
• InChiKey: ZHIIPMFWALAGFI-SFYZADRCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  68.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (3S,4R)-3-amino-4-[2-(furan-2-yl)ethyl]azetidin-2-one 在 4-二甲氨基吡啶 、 potassium tert-butylate 、 sodium hydride 、 臭氧 、 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 生成 p-nitrobenzyl 7β-[(phenoxyacetyl)amino]-3-hydroxy-1-carba-1-dethia-3-cephem-4-carboxylate
  参考文献：
  名称：

  羧苄青霉素抗生素的合成：使用苯基酯通过狄克曼反应合成来指导环化的区域选择性

  摘要：

  由多种对映体纯的二酯合成了可用于精制羧甲基的β-酮酸酯。证明了使用苯基酯指导区域选择性。

  DOI：

  10.1016/s0040-4039(00)97052-7
• 作为产物：
  描述：

  1-benzyl-3β-((S)-2-oxo-4-phenyloxazolidin-3-yl)-4β-[2-(2-furyl)ethyl]azetidin-2-one 在 氨 、 lithium 、 叔丁醇 作用下， 生成 (3S,4R)-3-amino-4-[2-(furan-2-yl)ethyl]azetidin-2-one
  参考文献：
  名称：

  羧苄青霉素抗生素的合成：使用苯基酯通过狄克曼反应合成来指导环化的区域选择性

  摘要：

  由多种对映体纯的二酯合成了可用于精制羧甲基的β-酮酸酯。证明了使用苯基酯指导区域选择性。

  DOI：

  10.1016/s0040-4039(00)97052-7

文献信息

• Antibiotic C-3 cyclobutenedione substituted (1-carba)cephalosporin
  申请人：Bristol-Myers Squibb Co.

  公开号：US05106842A1

  公开（公告）日：1992-04-21

  A compound of formula I ##STR1## wherein X is sulfur or CH.sub.2 ; R.sup.1 is hydrogen, hydroxy, amino, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, phenyl optionally substituted with one to three C.sub.1-6 alkyl, C.sub.1-6 alkyloxy or hydroxy, C.sub.1-6 alkylthio, phenylthio optionally substituted with one to three C.sub.1-6 alkyl or C.sub.1-6 alkyloxy on the phenyl ring, phenylmethyloxy optionally substituted with one to three C.sub.1-6 alkyl or C.sub.1-6 alkyloxy on the phenyl ring, 1-morpholino, C.sub.1-6 alkyloxy, C.sub.2-6 alkenylmethyloxy, C.sub.3-6 alkynylmethyloxy, C.sub.1-6 alkylamino, C.sub.1-6 dialkylamino or a radical selected from the group consisting of ##STR2## in which n is 0 to 3, R.sup.5 is C.sub.1-6 alkyl or hydrogen, and R.sup.3 and R.sup.4 are independently C.sub.1-6 alkyl; R.sup.2 is hydrogen, a conventional amino protecting group or an acyl group; R.sup.0 is hydrogen or a conventional carboxy protecting group, or --CO.sub.2 R.sup.0 taken together forms a physiologically hydrolyzable ester; or pharmaceutically acceptable salts or solvates thereof.

  化合物的化学式为I ##STR1## 其中X是硫或CH.sub.2; R.sup.1是氢，羟基，氨基，C.sub.1-6烷基，C.sub.2-6烯基，C.sub.2-6炔基，苯基，该苯基可选地被1-3个C.sub.1-6烷基，C.sub.1-6烷氧基或羟基，C.sub.1-6烷基硫基，苯基硫基取代，该苯环上的1-3个C.sub.1-6烷基或C.sub.1-6烷氧基，苯基甲氧基，该苯环上的1-3个C.sub.1-6烷基或C.sub.1-6烷氧基，1-吗啉基，C.sub.1-6烷氧基，C.sub.2-6烯基甲氧基，C.sub.3-6炔基甲氧基，C.sub.1-6烷基氨基，C.sub.1-6二烷基氨基或从所述群中选择的基团之一##STR2## 其中n为0至3，R.sup.5为C.sub.1-6烷基或氢，R.sup.3和R.sup.4独立地为C.sub.1-6烷基; R.sup.2是氢，传统的氨基保护基或酰基; R.sup.0是氢或传统的羧基保护基，或--CO.sub.2 R.sup.0在一起形成生理可水解的酯;或其药学上可接受的盐或溶剂。
• Antibiotic C-3 cyclobutenedione substituted (1-carba) cephalosporin
  申请人：Bristol-Myers Squibb Company

  公开号：US05169843A1

  公开（公告）日：1992-12-08

  A compound for formula I ##STR1## wherein X is sulfur or CH.sub.2 ; R.sup.1 is hydrogen, hydroxy, amino, C.sub.1-6 alkyl, C.sub.2-5 alkenyl, C.sub.2-6 alkynyl, phenyl optionally substituted with one to three C.sub.1-6 alkyl, C.sub.1-6 alkyloxy or hydroxy, C.sub.1-6 alkylthio, phenylthio optionally substituted with one to three C.sub.1-6 alkyl or C.sub.1-6 alkyloxy on the phenyl ring, phenylmethyloxy optionally substituted with one to three C.sub.1-6 alkyl or C.sub.1-6 alkyloxy on the phenyl ring, 1-morpholino, C.sub.1-6 alkyloxy, C.sub.2-6 alkenylmethyloxy, C.sub.3-6 alkynylmethyloxy, C.sub.1-6 alkylamino, C.sub.1-6 dialkylamino or a radical selected from the group consisting of ##STR2## in which n is 0 to 3, R.sup.5 is C.sub.1-6 alkyl or hydrogen, and R.sup.3 and R.sup.4 are independently C.sub.1-6 alkyl; R.sup.2 is hydrogen, a conventional amino protecting group or an acyl group; R.sup.0 is hydrogen or a conventional carboxy protecting group, or --CO.sub.2 R.sup.0 taken together forms a physiologically hydrolyzable ester; or pharmaceutically acceptable salts or solvates thereof.

  化合物的化学式为I ##STR1## 其中 X 为硫或CH.sub.2；R.sup.1 为氢、羟基、氨基、C.sub.1-6烷基、C.sub.2-5烯基、C.sub.2-6炔基、苯基，所述苯基可选用1-3个C.sub.1-6烷基、C.sub.1-6烷氧基或羟基、C.sub.1-6烷硫基，苯硫基可选用1-3个C.sub.1-6烷基或C.sub.1-6烷氧基取代苯环，苯甲氧基可选用1-3个C.sub.1-6烷基或C.sub.1-6烷氧基取代苯环，1-吗啉基、C.sub.1-6烷氧基、C.sub.2-6烯基甲氧基、C.sub.3-6炔基甲氧基、C.sub.1-6烷基氨基、C.sub.1-6二烷基氨基或从下列组中选择的基团之一：##STR2## 其中n为0至3，R.sup.5为C.sub.1-6烷基或氢，R.sup.3和R.sup.4独立地为C.sub.1-6烷基；R.sup.2为氢、传统的氨基保护基或酰基；R.sup.0为氢或传统的羧基保护基，或--CO.sub.2R.sup.0结合形成生理水解酯；或其药学上可接受的盐或溶剂。
• Antibiotic C-3 cyclobutenedione substituted (1-carba)cephalosporin compounds, compositions, and methods of use thereof
  申请人：Bristol-Myers Squibb Company

  公开号：EP0484030A2

  公开（公告）日：1992-05-06

  A compound of formula I wherein X is sulfur or CH2; R1 is hydrogen, hydroxy, amino, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, phenyl optionally substituted with one to three C1-6 alkyl, C1-6 alkyloxy or hydroxy, C1-6 alkylthio, phenylthio optionally substituted with one to three C1-6 alkyl or C1-6 alkyloxy on the phenyl ring, phenylmethyloxy optionally substituted with one to three C1-6 alkyl or C1-6 alkyloxy on the phenyl ring, 1-morpholino, C1-6 alkyloxy, C2-6 alkenylmethyloxy, C3-6 alkynylmethyloxy, C1-6 alkylamino, C1-6 dialkylamino or a radical selected from the group consisting of and in which n is 0 to 3, R5 is C1-6 alkyl or hydrogen, and R3 and R4 are independently C1-6 alkyl ; R2 is hydrogen, a conventional amino protecting group or an acyl group ; R° is hydrogen or a conventional carboxy protecting group, or -COZR° taken together forms a physiologically hydrolyzable ester; or pharmaceutically acceptable salts or solvates thereof.

  式 I 的化合物 其中 X 是硫或 CH2； R1 是氢、羟基、氨基、C1-6 烷基、C2-6 烯基、C2-6 炔基、任选被一至三个 C1-6 烷基、C1-6 烷氧基或羟基取代的苯基、C1-6 烷硫基、任选被一至三个 C1-6 烷基或 C1-6 烷氧基取代的苯环上的苯硫基、在苯环上任选被一至三个 C1-6 烷基或 C1-6 烷氧基取代的苯甲氧基、1-吗啉基、C1-6 烷氧基、C2-6 烯基甲基氧基、C3-6 烷炔基甲基氧基、C1-6 烷基氨基、C1-6 二烷基氨基或选自以下组的基团 和 其中 n 为 0 至 3，R5 为 C1-6 烷基或氢，R3 和 R4 独立地为 C1-6 烷基； R2 是氢、常规氨基保护基团或酰基； R° 是氢或常规羧基保护基团，或 -COZR° 合在一起形成生理上可水解的酯；或 其药学上可接受的盐或溶剂。
• JACKSON, BILL G.;GARDNER, JOHN P.;HEATH, PERRY C., TETRAHEDROM LETT., 31,(1990) N, C. 6317-6320
  作者：JACKSON, BILL G.、GARDNER, JOHN P.、HEATH, PERRY C.

  DOI：——

  日期：——
• US5106842A
  申请人：——

  公开号：US5106842A

  公开（公告）日：1992-04-21