propionic acid-[2]pyridylmethyl ester | 98996-07-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: propionic acid-[2]pyridylmethyl ester
• 英文别名: Propionsaeure-[2]pyridylmethylester；Pyridin-2-ylmethyl propanoate
• CAS: 98996-07-7
• 化学式: C₉H₁₁NO₂
• 分子量: 165.192
• InChiKey: FSEIXSOCURTFQL-UHFFFAOYSA-N

物化性质

• 沸点：
  89 °C(Press: 2.5 Torr)
• 密度：
  1.086±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-吡啶甲醇 在 Crabtree catalyst 氢气 、 三乙胺 作用下， 以 甲醇 、 乙醚 为溶剂， 25.0 ℃ 、101.33 kPa 条件下， 反应 25.0h， 生成 propionic acid-[2]pyridylmethyl ester
  参考文献：
  名称：

  Auxiliary accelerated reactions: Towards the use of catalytic chiral auxiliaries

  摘要：

  In competition experiments, the acceleration of reactivity of alkenes tethered to pyridyl groups compared with the corresponding alkenes tethered to phenyl groups in the presence of transition metals was demonstrated for two reaction types: Diels-Alder cycloaddition of enoate esters and catalytic hydrogenation of allylic and homoallylic ethers. The rate accelerations observed are of crucial importance in the development of a new concept for asymmetric catalysis: chiral auxiliaries which can function in a catalytic manner. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00829-6

文献信息

• Auxiliary accelerated reactions: catalytic hydrogenation
  作者：Andrew D. Westwell、Jonathan M. J. Williams

  DOI：10.1039/p19960000001

  日期：——

  In competition experiments, alkenes tethered to pyridyl groups were found to undergo iridium catalysed hydrogenation more quickly than alkenes tethered to phenyl groups. This is in marked contrast to the results for hydrogenation of some of the individual substrates where alkenes tethered to pyridyl groups were reduced much more slowly than their phenyl counterparts.

  在竞争实验中，连接至吡啶基的烯烃被发现比连接至苯基的烯烃更快地经历铱催化氢化。这与一些单一底物的氢化结果形成了鲜明对比，其中连接至吡啶基的烯烃的还原速度远低于其苯基对应物。
• Inhibitors of Histone Deacetylase
  申请人：Frechette Sylvie

  公开号：US20110212965A1

  公开（公告）日：2011-09-01

  The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions. One aspect of the invention provides compounds of formula (1): in which T, A and X are as described herein.

  该发明涉及抑制组蛋白去乙酰化酶的方法。该发明提供了抑制组蛋白去乙酰化酶酶活性的化合物和方法。该发明还提供了用于治疗细胞增殖性疾病和状况的组合物和方法。该发明的一个方面提供了式（1）的化合物：其中T，A和X如本文所述。
• Chelation-Assisted Hydroesterification of Alkenes Catalyzed by Rhodium Complex
  作者：Kazuhiko Yokota、Hiroto Tatamidani、Yoshiya Fukumoto、Naoto Chatani

  DOI：10.1021/ol035582e

  日期：2003.11.1

  The hydroesterification of alkenes with 2-pyridylmethanol (1) catalyzed by Rh-4(CO)(12) is described. The reaction is accelerated by the presence of a pyridine ring in the alcohol 1. The reaction is applicable to various alkenes, both terminal and internal alkenes.
• Solvent-free transesterification in a ball-mill over alumina surface
  作者：Tanmay Chatterjee、Debasree Saha、Brindaban C. Ranu

  DOI：10.1016/j.tetlet.2012.05.127

  日期：2012.8

  An efficient procedure for transesterification has been developed in a ball-mill in the absence of any solvent, acid/base or metal catalyst. A variety of methyl, ethyl, allyl esters have been transesterified to higher benzyl and other esters in high yields by this procedure. (C) 2012 Elsevier Ltd. All rights reserved.
• Alkylation of Organic Acids with Pyridotriazole¹
  作者：J. H. Boyer、L. T. Wolford

  DOI：10.1021/ja01544a040

  日期：1958.6