ethyl (5-trifluoromethylpyridin-2-yl)butanoate | 1100766-42-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl (5-trifluoromethylpyridin-2-yl)butanoate
• 英文别名: ethyl 4-(5-(trifluoromethyl)pyridin-2-yl)butanoate；ethyl 4-[5-(trifluoromethyl)pyridin-2-yl]butanoate
• CAS: 1100766-42-4
• 化学式: C₁₂H₁₄F₃NO₂
• 分子量: 261.244
• InChiKey: AFMNALMEPJRKLG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  ethyl (5-trifluoromethylpyridin-2-yl)butanoate 在 水 、 sodium hydroxide 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 生成 4-(5-(trifluoromethyl)pyridin-2-yl)butanoic acid
  参考文献：
  名称：

  Synthesis of novel tetrahydroisoquinoline bronchodilators

  摘要：

  The synthesis and bronchorelaxing effects of a series of novel tetrahydroisoquinoline amides are described. The compounds were evaluated for their ability to relax LTD4 contracted isolated human small airways ex-vivo. Several compounds demonstrated highly efficacious bronchorelaxing properties. Cinnamide 71 was selected for further studies and constitutes a promising candidate as a novel bronchorelaxing agent for the treatment of pulmonary disorders. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.07.057
• 作为产物：
  描述：

  bromo(4-ethoxy-4-oxobutyl)zinc 、 2-溴-5-(三氟甲基)吡啶 在 [1,3-bis(2,6-diisopropyl-phenyl)imidazol-2-ylidene](3-chloropyridyl)-palladium(II) dichloride 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 以80%的产率得到ethyl (5-trifluoromethylpyridin-2-yl)butanoate
  参考文献：
  名称：

  Synthesis of novel tetrahydroisoquinoline bronchodilators

  摘要：

  The synthesis and bronchorelaxing effects of a series of novel tetrahydroisoquinoline amides are described. The compounds were evaluated for their ability to relax LTD4 contracted isolated human small airways ex-vivo. Several compounds demonstrated highly efficacious bronchorelaxing properties. Cinnamide 71 was selected for further studies and constitutes a promising candidate as a novel bronchorelaxing agent for the treatment of pulmonary disorders. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.07.057

文献信息

• Nickel-Catalyzed Cross-Electrophile Coupling of 2-Chloropyridines with Alkyl Bromides
  作者：Daniel Weix、Daniel Everson、Joseph Buonomo

  DOI：10.1055/s-0033-1340151

  日期：——

  of 2-alkylated pyridines by the nickel-catalyzed cross-coupling of two different electrophiles, 2-chloropyridines with alkyl bromides, is described. Compared to our previously published conditions for aryl halides, this method uses the different, more rigid bathophenanthroline ligand and is conducted at high concentration in DMF solvent. The method displays promising functional group compatibility and

  描述了通过镍催化的两种不同亲电子试剂（2-氯吡啶与烷基溴）的交叉偶联合成 2-烷基化吡啶。与我们之前公布的芳基卤化物条件相比，该方法使用不同的、更刚性的红菲咯啉配体，并在 DMF 溶剂中以高浓度进行。该方法显示出有希望的官能团兼容性，并且条件与 Stille 耦合正交。
• [EN] NOVEL BRONCHODILATING ISOQUINOLINE AMIDES<br/>[FR] NOUVEAUX AMIDES D'ISOQUINOLÉINE BRONCHODILATATEURS
  申请人：RESPIRATORIUS AB

  公开号：WO2009007418A1

  公开（公告）日：2009-01-15

  The invention relates to novel compounds having the general formula I, and which compounds are useful to manufacture a medicament to treat a disorder or disease characterized by bronchoconstriction, e.g. COPD and asthma, and vasoconstriction, e.g. hypertension.

  该发明涉及具有一般式I的新化合物，这些化合物可用于制造用于治疗由支气管痉挛引起的紊乱或疾病的药物，例如慢性阻塞性肺疾病（COPD）和哮喘，以及由血管收缩引起的疾病，例如高血压。