1-(4,5-dimethoxy-2-nitrophenyl)propane-1,3-diol | 253873-43-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4,5-dimethoxy-2-nitrophenyl)propane-1,3-diol
• 英文别名: 1-(4,5-Dimethoxy-2-nitro-phenyl)-propane-1,3-diol
• CAS: 253873-43-7
• 化学式: C₁₁H₁₅NO₆
• 分子量: 257.243
• InChiKey: GVCRGACLEDWMEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-(4,5-dimethoxy-2-nitrophenyl)propane-1,3-diol 在 吡啶 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 27.5h， 生成
  参考文献：
  名称：

  Optical Control of MicroRNA Function in Zebrafish Embryos

  摘要：

  DOI：

  10.1021/jacs.2c04479
• 作为产物：
  描述：

  C₁₂H₁₇NO₇ 在 sodium tetrahydroborate 、 sodium periodate 、 乙醇 作用下， 以 水 、 丙酮 为溶剂， 反应 6.0h， 生成 1-(4,5-dimethoxy-2-nitrophenyl)propane-1,3-diol
  参考文献：
  名称：

  Optical Control of MicroRNA Function in Zebrafish Embryos

  摘要：

  DOI：

  10.1021/jacs.2c04479

文献信息

• An Enantioselective Total Synthesis of (−)‐Isoschizogamine
  作者：Zhengren Xu、Xu Bao、Qian Wang、Jieping Zhu

  DOI：10.1002/anie.201508150

  日期：2015.12

  domino sequence. The one‐pot process leading to the formation of one CC bond and three CN bonds created three rings and three contiguous stereogenic centers with complete control of both the relative and absolute stereochemistry.

  简明的对映选择性全合成（-）-异麦草胺，一种复杂的桥联多环单萜吲哚生物碱。将对映体富集的亚胺与烷基碘进行N烷基化反应得到亚胺盐，该亚胺盐在新戊酸存在下通过微波辐射加热后，通过复杂但有序的多米诺序列转化为天然产物的六环结构。通过一锅法形成一个CC键和三个CN键形成了三个环和三个连续的立体中心，这些中心完全控制了相对和绝对立体化学。
• Cyclic Caged Morpholinos: Conformationally Gated Probes of Embryonic Gene Function
  作者：Sayumi Yamazoe、Ilya A. Shestopalov、Elayne Provost、Steven D. Leach、James K. Chen

  DOI：10.1002/anie.201201690

  日期：2012.7.9

  Feeling a bit cagey: Morpholino‐based antisense reagents have been caged through oligonucleotide cyclization (see scheme), enabling photocontrol of gene expression in zebrafish embryos and larvae. Using these reagents, the timing of exocrine cell fate commitment in the developing pancreas has been examined.

  感觉有点笼统：基于吗啉代的反义试剂已通过寡核苷酸环化（见方案）被笼子笼罩，从而能够对斑马鱼胚胎和幼虫中的基因表达进行光控制。使用这些试剂，已经检查了发育中的胰腺中外分泌细胞命运承诺的时间。
• Design, synthesis and activity of light deactivatable microRNA inhibitor
  作者：Hao Yan、Umesh Bhattarai、Yabin Song、Fu-Sen Liang

  DOI：10.1016/j.bioorg.2018.07.003

  日期：2018.10

  miRNAs are key cellular regulators and their dysregulation is associated with many human diseases. They are usually produced locally in a spatiotemporally controlled manner to target mRNAs and regulate gene expression. Thus, developing chemical tools for manipulating miRNA with spatiotemporal precise is critical for studying miRNA. Herein, we designed a strategy to control miRNA biogenesis with light controllable inhibitor targeting the pre-miRNA processing by Dicer. By conjugating two non-inhibiting units, a low affinity Dicer inhibitor and a pre-miRNA binder, through a photocleavable linker, the bifunctional molecule obtained could inhibit miRNA production. Taking advantage of the photocleavable property of the linker, the bifunctional inhibitor can be fragmented into separate non-inhibiting units and therefore be deactivated by light. We expect that this strategy could be applied to generate chemical biological tools that allow light-mediated spatiotemporal control of miRNA maturation and contribute to the study of miRNA function.