2,5,5-tribenzyl-pyrazolidin-3-one | 657395-52-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,5,5-tribenzyl-pyrazolidin-3-one
• 英文别名: 2,5,5-Tribenzylpyrazolidin-3-one；2,5,5-tribenzylpyrazolidin-3-one
• CAS: 657395-52-3
• 化学式: C₂₄H₂₄N₂O
• 分子量: 356.467
• InChiKey: GYMDJYDUIDMMPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二苄基甲酮 在 sodium hydride 、 potassium carbonate 、 一水合肼 、 sodium iodide 作用下， 以 四氢呋喃 、 丁酮 、 正丁醇 为溶剂， 生成 2,5,5-tribenzyl-pyrazolidin-3-one
  参考文献：
  名称：

  Exo Selective Enantioselective Nitrone Cycloadditions

  摘要：

  We have developed a novel method for accessing exo adducts with high enantioselectivity in nitrone cycloadditions to enoates. Pyrazolidinones proved to be effective achiral templates in the cycloadditions, providing exo adducts typically in >15:1 selectivity and 90-98% ee. The use of Lewis acids that form square planar complexes, such as copper triflate, was important for obtaining high exo selectivity.

  DOI：

  10.1021/ja039087p

文献信息

• Exo Selective Enantioselective Nitrone Cycloadditions
  作者：Mukund P. Sibi、Zhihua Ma、Craig P. Jasperse

  DOI：10.1021/ja039087p

  日期：2004.1.28

  We have developed a novel method for accessing exo adducts with high enantioselectivity in nitrone cycloadditions to enoates. Pyrazolidinones proved to be effective achiral templates in the cycloadditions, providing exo adducts typically in >15:1 selectivity and 90-98% ee. The use of Lewis acids that form square planar complexes, such as copper triflate, was important for obtaining high exo selectivity.