(2S)-2-(hydroxymethyl)-1,4-benzodioxan tosylate | 62501-73-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S)-2-(hydroxymethyl)-1,4-benzodioxan tosylate
• 英文别名: (2S)-2-tosyloxymethyl-1,4-benzodioxane；(S)-2-(tosylmethyl)-1,4-benzodioxane；toluene-4-sulfonic acid (2S)-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl ester；(S)-1,4-benzodioxan-2-ylmethyl toluene-4-sulphonate；(2R)-2-Tosyloxymethyl-1,4-benzodioxan；(2S)-2-Tosyloxymethyl-1,4-benzodioxan；(2s)-Tosyloxymethyl-benzo(1,4)dioxane；[(3S)-2,3-dihydro-1,4-benzodioxin-3-yl]methyl 4-methylbenzenesulfonate
• CAS: 62501-73-9
• 化学式: C₁₆H₁₆O₅S
• 分子量: 320.366
• InChiKey: OTGAYUCEDFKLHW-ZDUSSCGKSA-N

物化性质

• 沸点：
  471.6±24.0 °C(Predicted)
• 密度：
  1.290±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  70.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2S)-2-(hydroxymethyl)-1,4-benzodioxan tosylate 在 一水合肼 作用下， 以 乙二醇甲醚 、 N,N-二甲基甲酰胺 为溶剂， 生成 (R)-WB-4101
  参考文献：
  名称：

  Ferri; Pallavicini; Piccini, Farmaco, Edizione Scientifica, 1988, vol. 43, # 12 SUPPL., p. 1153 - 1163

  摘要：

  DOI：
• 作为产物：
  描述：

  (2S)-1-(2'-benzyloxyphenoxy)-3-benzyloxy-2-propanol 在 palladium on activated charcoal 吡啶 、 氢气 作用下， 生成 (2S)-2-(hydroxymethyl)-1,4-benzodioxan tosylate
  参考文献：
  名称：

  Ferri; Pallavicini; Piccini, Farmaco, Edizione Scientifica, 1988, vol. 43, # 12 SUPPL., p. 1153 - 1163

  摘要：

  DOI：

文献信息

• USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR LOWERING LIPIDS AND LOWERING BLOOD GLUCOSE LEVELS
  申请人：Smith-Swintosky L. Virginia

  公开号：US20070155821A1

  公开（公告）日：2007-07-05

  The present invention is a method for the glucose related disorders and lipid related disorders comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) or formula (II) as herein defined. The present invention is further directed to methods of treatment comprising co-therapy with an anti-diabetic agent, and anti-lipid agent and/or an anti-obesity agent.

  本发明涉及一种治疗葡萄糖相关疾病和脂质相关疾病的方法，包括向需要的受试者施用一种或多种新型苯并杂环磺胺衍生物的治疗有效量，其化学结构如公式(I)或公式(II)所定义。本发明还涉及治疗方法，包括与抗糖尿病药物、抗脂质药物和/或抗肥胖药物联合治疗。
• USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF DEPRESSION
  申请人：Smith-Swintosky L. Virginia

  公开号：US20070155827A1

  公开（公告）日：2007-07-05

  The present invention is a method for the treatment of depression comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) and formula (II) as herein defined. The present invention is directed to a method for the treatment of depression, which includes mono-therapy and alternatively, co-therapy with at least one antidepressant.

  本发明涉及一种治疗抑郁症的方法，包括向需要的受试者施用一种或多种新型苯并杂环磺酰胺衍生物的治疗有效量，其化学式为(I)和(II)。本发明涉及一种治疗抑郁症的方法，包括单独治疗和/或与至少一种抗抑郁药物联合治疗。
• USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN
  申请人：Smith-Swintosky L. Virginia

  公开号：US20070155822A1

  公开（公告）日：2007-07-05

  The present invention is a method for the treatment of pain comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) and formula (II) as described herein. The present invention is further directed to methods for the treatment of pain comprising co-therapy with analgesic agent(s) and a compound of formula (I) or formula (II) as described herein.

  本发明涉及一种用于治疗疼痛的方法，包括向需要的受试者施用一种或多种根据本文描述的新型苯并杂环磺酰胺衍生物的治疗有效量。本发明还涉及一种治疗疼痛的方法，包括与镇痛剂联合治疗，并根据本文描述的化合物的公式(I)或公式(II)。
• USE OF BENZO-FUSED HETEROCYLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF MIGRAINE
  申请人：Smith-Swintosky Virginia L.

  公开号：US20070191474A1

  公开（公告）日：2007-08-16

  The present invention is a method for the treatment or prevention of migraine comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) and formula (II) as herein defined. The present invention is directed to a method for the treatment and/or prevention of migraine, which includes mono-therapy and alternatively, co-therapy with at least anti-migraine agent.

  本发明是一种治疗或预防偏头痛的方法，包括向需要的受试者施用一种或多种新型苯并杂环磺酰胺衍生物的治疗有效量，其化学式为(I)和(II)。本发明涉及一种治疗和/或预防偏头痛的方法，包括单独治疗，或与至少一种抗偏头痛药物联合治疗。
• Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
  申请人：McComsey F. David

  公开号：US20050282887A1

  公开（公告）日：2005-12-22

  The present invention is directed to novel sulfamide and sulfamate derivatives, pharmaceutical compositions containing them and their use in the treatment of epilepsy and related disorders.

  本发明涉及新型磺胺酰胺和磺酸酯衍生物，包括含有它们的药物组合物以及它们在治疗癫痫和相关疾病中的用途。