3-(tert-butyl)-2-((4-methoxybenzyl)oxy)benzaldehyde

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(tert-butyl)-2-((4-methoxybenzyl)oxy)benzaldehyde
• 英文别名: 3-tert-Butyl-2-(4-methoxybenzyloxy)benzaldehyde；3-tert-butyl-2-[(4-methoxyphenyl)methoxy]benzaldehyde
• 化学式: C₁₉H₂₂O₃
• 分子量: 298.382
• InChiKey: LSHYDIVFIVKFJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  硝酸甲酯 、 3-(tert-butyl)-2-((4-methoxybenzyl)oxy)benzaldehyde 在 ammonium acetate 作用下， 反应 1.0h， 以40%的产率得到(E)-1-(tert-butyl)-2-((4-methoxybenzyl)oxy)-3-(2-nitrovinyl)benzene
  参考文献：
  名称：

  Organocatalytic Route to Dihydrocoumarins and Dihydroquinolinones in All Stereochemical Configurations

  摘要：

  A straightforward stereodivergent route to dihydrocoumarins and dihydroquinolinones based on cinchona alkaloid catalyzed addition reactions of monothiomalonates (MTMs) to functionalized nitroolefins followed by deprotection and chemoselective cyclization has been developed. The synthesis proceeds under mild conditions and yields heterocycles with adjacent quaternary and tertiary stereogenic centers in very high yields and stereoselectivities. Moreover, full control over the relative and absolute configuration is achieved by the use of (pseudo)enantiomeric catalysts and the difference in reactivity of thioester versus oxoester moieties.

  DOI：

  10.1021/ol502697s
• 作为产物：
  描述：

  3-叔丁基-2-羟基苯甲醛 、 4-甲氧基氯苄 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以99%的产率得到3-(tert-butyl)-2-((4-methoxybenzyl)oxy)benzaldehyde
  参考文献：
  名称：

  Organocatalytic Route to Dihydrocoumarins and Dihydroquinolinones in All Stereochemical Configurations

  摘要：

  A straightforward stereodivergent route to dihydrocoumarins and dihydroquinolinones based on cinchona alkaloid catalyzed addition reactions of monothiomalonates (MTMs) to functionalized nitroolefins followed by deprotection and chemoselective cyclization has been developed. The synthesis proceeds under mild conditions and yields heterocycles with adjacent quaternary and tertiary stereogenic centers in very high yields and stereoselectivities. Moreover, full control over the relative and absolute configuration is achieved by the use of (pseudo)enantiomeric catalysts and the difference in reactivity of thioester versus oxoester moieties.

  DOI：

  10.1021/ol502697s

文献信息

• Catalyst Compounds and Use Thereof
  申请人：GIESBRECHT Garth R.

  公开号：US20110098431A1

  公开（公告）日：2011-04-28

  This invention relates to Group 4 dialkyl compounds supported by a pyridyl-amido-aryl (“PAA”), an anisole-amido-aryl (“AAA”), a phenoxy-amido-pyridyl (“PAPY”), an anisole-amido-phenoxy (“AAP”) or a anisole-amido-phenoxy (“AAP”) tridentate ligand. Such compounds can polymerize olefins, such as ethylene.

  本发明涉及由吡啶基氨基芳基（“PAA”）、甲氧基基氨基芳基（“AAA”）、苯氧基氨基吡啶基（“PAPY”）、甲氧基基氨基苯氧基（“AAP”）或甲氧基基苯氧基（“AAP”）三齿配体支撑的第四族二烷基化合物。这些化合物可以聚合烯烃，例如乙烯。
• Catalyst compounds and use thereof
  申请人：Giesbrecht Garth R.

  公开号：US08530593B2

  公开（公告）日：2013-09-10

  This invention relates to Group 4 dialkyl compounds supported by a pyridyl-amido-aryl (“PAA”), an anisole-amido-aryl (“AAA”), a phenoxy-amido-pyridyl (“PAPY”), an anisole-amido-phenoxy (“AAP”) or a anisole-amido-phenoxy (“AAP”) tridentate ligand. Such compounds can polymerize olefins, such as ethylene.

  本发明涉及由吡啶基氨基苯基（“PAA”）、甲氧基基氨基苯基（“AAA”）、苯氧基氨基吡啶基（“PAPY”）、甲氧基基氨基苯氧基（“AAP”）或甲氧基基苯氧基（“AAP”）三牙配体支持的第四族二烷基化合物。此类化合物可以聚合烯烃，例如乙烯。
• US8530593B2
  申请人：——

  公开号：US8530593B2

  公开（公告）日：2013-09-10
• Organocatalytic Route to Dihydrocoumarins and Dihydroquinolinones in All Stereochemical Configurations
  作者：Oliver D. Engl、Sven P. Fritz、Alexander Käslin、Helma Wennemers

  DOI：10.1021/ol502697s

  日期：2014.10.17

  A straightforward stereodivergent route to dihydrocoumarins and dihydroquinolinones based on cinchona alkaloid catalyzed addition reactions of monothiomalonates (MTMs) to functionalized nitroolefins followed by deprotection and chemoselective cyclization has been developed. The synthesis proceeds under mild conditions and yields heterocycles with adjacent quaternary and tertiary stereogenic centers in very high yields and stereoselectivities. Moreover, full control over the relative and absolute configuration is achieved by the use of (pseudo)enantiomeric catalysts and the difference in reactivity of thioester versus oxoester moieties.