bis-(4,5-dimethoxy-2-methyl-phenyl)-methane | 1164-05-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis-(4,5-dimethoxy-2-methyl-phenyl)-methane
• 英文别名: Bis-(4,5-dimethoxy-2-methyl-phenyl)-methan；1-[(4,5-Dimethoxy-2-methylphenyl)methyl]-4,5-dimethoxy-2-methylbenzene
• CAS: 1164-05-2
• 化学式: C₁₉H₂₄O₄
• 分子量: 316.397
• InChiKey: ZRAINUOVGRPDBP-UHFFFAOYSA-N

物化性质

• 熔点：
  124 °C
• 沸点：
  435.1±40.0 °C(Predicted)
• 密度：
  1.063±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  bis-(4,5-dimethoxy-2-methyl-phenyl)-methane 在 sodium dichromate 、 溶剂黄146 作用下， 生成 4,5,4',5'-tetramethoxy-2,2'-dimethyl-benzophenone
  参考文献：
  名称：

  Oliverio; Boumis, Gazzetta Chimica Italiana, 1951, vol. 81, p. 581,585

  摘要：

  DOI：
• 作为产物：
  描述：

  bis-(6-methyl-benzo[1,3]dioxol-5-yl)-methane 在 盐酸 、 乙醇 、 五氯化磷 、 potassium carbonate 、 硫酸二甲酯 作用下， 生成 bis-(4,5-dimethoxy-2-methyl-phenyl)-methane
  参考文献：
  名称：

  Dolce; Garofano, Annali di Chimica, 1957, vol. 47, p. 1185,1196

  摘要：

  DOI：

文献信息

• Acid Catalysis vs. Electron-Transfer Catalysis via Organic Cations or Cation-Radicals as the Reactive Intermediate. Are These Distinctive Mechanisms?
  作者：Rajendra Rathore、Jay K. Kochi、Augusto Canavesi、Larry L. Miller、Giovanni V. Sebastiani、George W. Francis、József Szúnyog、Bengt Långström

  DOI：10.3891/acta.chem.scand.52-0114

  日期：——

  Proton transfer to aromatic and olefinic donors (D) lends to the facile interchange of transient carbocations (DH+) and cation-radical (D+.). The same types of cation and cation-radical are reactive intermediates in the acid catalysis and the electron-transfer catalysis of such organic transformations as benzylic coupling, epoxide.-pinacol rearrangements and cis-trans isomerization of stilbenes when they are both carried out under otherwise identical reaction conditions, However, the rapid exchange of diamagnetic cations and paramagnetic cation-radicals blurs the traditional view of sepal ate electrophilic and homolytic processes, and rigorous experimental evidence is required to establish whether acid catalysis and electron-transfer catalysis actually represent distinct mechanistic categories.
• Some Nuclear-Substituted Derivatives of α-Methyldopa¹
  作者：Anilkumar Parulkar、Alfred Burger、Dorothea Aures

  DOI：10.1021/jm00323a022

  日期：1966.9
• Radical-Cation Catalysis in the Synthesis of Diphenylmethanes via the Dealkylative Coupling of Benzylic Ethers
  作者：Rajendra Rathore、Jay K. Kochi

  DOI：10.1021/jo00128a020

  日期：1995.11

  The dealkylative coupling of benzyl alkyl ethers (ArCH(2)OR) to yield the corresponding diarylmethanes (ArCH2Ar) together with dialkoxymethane (ROCH(2)OR) is catalyzed by small amounts of 1-electron oxidants (such as aromatic cation radicals, NO+, etc.) or py an equivalent electrochemical (anodic) method. The catalytic method is successfully employed for the facile synthesis of a novel macrocyclic crown ether 18 that contains a diarylmethane linkage. On the basis of the spectral observation of the radical cation ArCH(2)OR(.+) and the excellent catalytic efficiency with turnover numbers in excess of 10(2), an electron-transfer and an alternative electrophilic chain mechanism are discussed for the dealkylative coupling process.
• Arcoleo; Garofano, Annali di Chimica, 1957, vol. 47, p. 1142,1161
  作者：Arcoleo、Garofano

  DOI：——

  日期：——
• 253. Some bis-1 : 1′-spiroindanes
  作者：Wilson Baker、H. L. Williams

  DOI：10.1039/jr9590001295

  日期：——