N-(4-氨基苯基)-N-苯基苯甲酰胺 | 73333-83-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-(4-氨基苯基)-N-苯基苯甲酰胺
• 英文名称: N-phenyl-N-4-aminophenylbenzamide
• 英文别名: N-(4-amino-phenyl)-N-phenyl-benzamide；N-(4-Amino-phenyl)-N-phenyl-benzamid；N-Pheny-N-benzoyl-p-phenylendiamin；N-Phenyl-N-benzoyl-p-phenylendiamin；4-Amino-N-benzoyl-diphenylamin；N-(4-aminophenyl)-N-phenylbenzamide
• CAS: 73333-83-2
• 化学式: C₁₉H₁₆N₂O
• 分子量: 288.349
• InChiKey: FAWGLPAQCQELSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  N-(4-氨基苯基)-N-苯基苯甲酰胺 、 异硫氰酸 p-氯苯甲酰脂 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of aminopyrazine derivatives as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

  摘要：

  Several series of novel non-thiourea-containing aminopyrazine derivatives were designed based on the MK-2 inhibitors 1-(2-aminopyrazin-3-yl)methyl-2-thioureas. These compounds were synthesized and evaluated for their inhibitory activity against MK-2 enzyme in vitro. Compounds with low micromolar to sub-micromolar IC50 values were identified, and several compounds were also found to be active in suppressing the lipopolysaccharide (LPS)-stimulated TNF alpha production in THP-1 cells with minimum shift compared to their enzyme activity. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.09.016
• 作为产物：
  描述：

  N-(4-硝基苯基)-N-苯基苯甲酰胺 在 钯 氢气 作用下， 生成 N-(4-氨基苯基)-N-苯基苯甲酰胺
  参考文献：
  名称：

  Basic methanolysis of N-aryl-N-phenylbenzamides

  摘要：

  DOI：

  10.1021/jo01300a028

文献信息

• A Simple Copper-Catalyzed Synthesis of Tertiary Acyclic Amides
  作者：Emilie Racine、Florian Monnier、Jean-Pierre Vors、Marc Taillefer

  DOI：10.1021/ol200750p

  日期：2011.6.3

  The N-arylation of aromatic and aliphatic secondary acyclic amides, known to be poor nucleophiles, has been accomplished using a simple and cheap copper catalytic system. The corresponding tertiary acyclic amides, which can be found in numerous biologically active compounds, have been obtained in good to excellent yields.

  已知是不良亲核试剂的芳族和脂族仲无环酰胺的N-芳基化反应已使用简单廉价的铜催化体系完成。在许多生物活性化合物中可以找到相应的叔无环酰胺，其收率很好。
• Ford et al., Journal of the Chemical Society, 1953, p. 3529,3532
  作者：Ford et al.

  DOI：——

  日期：——
• Lellmann, Chemische Berichte, 1882, vol. 15, p. 830
  作者：Lellmann

  DOI：——

  日期：——
• Design, synthesis, and biological evaluation of aminopyrazine derivatives as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)
  作者：Songnian Lin、Sunita Malkani、Matthew Lombardo、Lihu Yang、Sander G. Mills、Kevin Chapman、James E. Thompson、Wen Xiao Zhang、Ruixiu Wang、Rose M. Cubbon、Edward A. O’Neill、Jeffrey J. Hale

  DOI：10.1016/j.bmcl.2015.09.016

  日期：2015.11

  Several series of novel non-thiourea-containing aminopyrazine derivatives were designed based on the MK-2 inhibitors 1-(2-aminopyrazin-3-yl)methyl-2-thioureas. These compounds were synthesized and evaluated for their inhibitory activity against MK-2 enzyme in vitro. Compounds with low micromolar to sub-micromolar IC50 values were identified, and several compounds were also found to be active in suppressing the lipopolysaccharide (LPS)-stimulated TNF alpha production in THP-1 cells with minimum shift compared to their enzyme activity. (C) 2015 Elsevier Ltd. All rights reserved.
• Basic methanolysis of N-aryl-N-phenylbenzamides
  作者：Trevor J. Broxton、Leslie W. Deady、Jeffrey E. Rowe

  DOI：10.1021/jo01300a028

  日期：1980.6