2-氯丙烯酰胺 | 16490-68-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-氯丙烯酰胺
• 英文名称: 2-chloroacrylamide
• 英文别名: 2-chloroprop-2-enamide
• CAS: 16490-68-9
• 化学式: C₃H₄ClNO
• mdl: MFCD19203485
• 分子量: 105.524
• InChiKey: YBXYCBGDIALKAK-UHFFFAOYSA-N

物化性质

• 熔点：
  94 °C(Solv: benzene (71-43-2))
• 沸点：
  253.5±32.0 °C(Predicted)
• 密度：
  1.239±0.06 g/cm3(Predicted)
• 溶解度：
  0.62 M

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2924199090

反应信息

• 作为反应物：
  描述：

  2-氯丙烯酰胺 生成 2-carbamoylaziridine
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氯丙烯腈 在 硫酸 作用下， 生成 2-氯丙烯酰胺
  参考文献：
  名称：

  Determinants of mortality in patients with advanced cirrhosis after transjugular intrahepatic portosystemic shunting

  摘要：

  Background & Aims: Transjugular intrahepatic portosystemic shunt (TIPS) placement is effective in the treatment of complications of portal hypertension. This study evaluated the predictors of mortality in a group of cirrhotic patients with advanced liver disease after placement of TIPS. Methods: A retrospective analysis of all patients undergoing TIPS placement over a 2 1/2-year period was undertaken. Results: Fifty-six patients had TIPS placement for variceal hemorrhage, 49 for refractory ascites, and 24 for hepatic hydrothorax (total, 129). Of 21 variables available before TIPS placement, variceal hemorrhage requiring emergent TIPS placement (relative risk [RR], 37.5; 95% confidence interval [CI], 5.4-259) and bilirubin concentration >3.0 mg/dL (RR, 5.4; 95% CI, 1.4-10.2) were independent predictors of 30-day mortality. Variceal hemorrhage requiring emergent TIPS placement (hazard ratio [HR], 5.1, 95% CI, 2.2-9.1), alanine aminotransferase level >100 IU/L (HR, 2.5; 95% CI, 1.2-5.5), bilirubin level >3.0 mg/dL (HR, 2.6; 95% CI, 1.1-4.6), and pre-TIPS encephalopathy unrelated to bleeding (HR, 2.2; 95% CI, 1.2-4.8) independently predicted death during the follow-up period. A model was developed that separated the patients into 3 groups with significantly different survival rates. Conclusions: A clinical index consisting of 4 pre-TIPS variables can reliably predict outcome after TIPS.

  DOI：

  10.1016/s0016-5085(00)70422-7

文献信息

• PROCESS FOR PREPARATION OF 1,2,3-TRIAZOLE-4 CARBOXAMIDES
  申请人：TARO PHARMACEUTICAL INDUSTRIES LIMITED

  公开号：US20140155619A1

  公开（公告）日：2014-06-05

  The invention relates to the preparation of 1,2,3-triazole-4-carboxamide of general Formula I: wherein R 1 and R 2 may be the same or different and are selected from H, F, Cl, Br, I, OR, C(O)R, NH 2 , NHR or NR 2 . R can be a linear or branched alkyl group, for example a C 1 -C 4 alkyl group. In exemplary embodiments, R 1 and R 2 are independently selected from H, F, Cl, Br, and I. The compound of Formula I can be Rufinamide.

  本发明涉及一种通式为I的1,2,3-三唑-4-羧酰胺的制备方法：其中R1和R2可以相同也可以不同，并且可以选择H，F，Cl，Br，I，OR，C（O）R，NH2，NHR或NR2。R可以是线性或支链烷基，例如C1-C4烷基。在示例实施中，R1和R2是独立选择的H，F，Cl，Br和I。公式I的化合物可以是鲁芬胺。
• A New Method for the Preparation of Amides from Nitriles by use of Hydroxylamines
  作者：Takeo Miyazawa、Takeshi Endo、Makoto Okawara

  DOI：10.1055/s-1984-31066

  日期：——
• Effenberger, Franz; Beisswenger, Thomas; Dannenhauer, Fritz, Chemische Berichte, 1988, vol. 121, p. 2209 - 2224
  作者：Effenberger, Franz、Beisswenger, Thomas、Dannenhauer, Fritz

  DOI：——

  日期：——
• Synthetic chemistry, neurotransmission and second messengers
  作者：Alan P. Kozikowski

  DOI：10.1002/jhet.5570270108

  日期：1990.1
• Glutamine metabolism stimulates intestinal cell MAPKs by a cAMP-inhibitable, RAF-independent mechanism
  作者：J.Marc Rhoads、Robert A. Argenzio、Wunian Chen、Lee M. Graves、Laura L. Licato、Anthony T. Blikslager、Judy Smith、John Gatzy、David A. Brenner

  DOI：10.1016/s0016-5085(00)70417-3

  日期：2000.1

  Background & Aims: Infectious diarrhea caused by viruses plus enterotoxigenic bacteria is often more severe than diarrhea induced by either pathogen alone. We postulated that the increased cell adenosine 3',5'-cyclic monophosphate (cAMP) concentration observed during infection by enterotoxigenic organisms retards the intestinal repair process by blocking activation of mitogen-activated protein kinases (MAPKs) in proliferating intestinal cells, Methods: We evaluated the effects of glutamine on MAPK activity, thymidine incorporation, and cell number in glutamine-starved and -sufficient rat intestinal crypt cells (IEC-6), Results: In glutamine-starved cells, 10 mmol/L glutamine in the absence of serum stimulated [H-3]thymidine incorporation 8-fold, This effect was inhibited by 60% with 8-(4-chlorophenylthio) (8-CPT)-cAMP (100 mu mol/L) + isobutyl methylxanthine (100 mu mol/L). In cells not starved of glutamine, glutamine stimulated thymidine incorporation by 3-fold, and 8-CPT-cAMP completely blocked the mitogenic effect, Inhibition of proliferation by cAMP persisted for at least 68 hours after cAMP removal, In vitro kinase assays showed that glutamine signaling requires an intact ERK (extracellular signal-related kinase) pathway in unstarved cells. In starved cells, at least one other pathway (JNK) was activated by glutamine, and the mitogenic inhibition by 8-CPT-cAMP was incomplete, Other intestinal fuels (glucose and acetate) were not mitogenic, Conclusions: Increased levels of intracellular cAMP inhibit ERKs but only partially reduce glutamine-stimulated proliferation in enterocytes adapted to low glutamine.