bis(2-{(E)-[(4-bromophenyl)imino]methyl}phenolate)cobalt(II) | 39018-65-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: bis(2-{(E)-[(4-bromophenyl)imino]methyl}phenolate)cobalt(II)
• 英文别名: trans-bis[N-(4-bromophenyl)salicylaldiminato]cobalt(II)；trans-bis[2-(4-bromophenyliminomethyl)phenolato-N,O]cobalt(II)
• CAS: 39018-65-0；16972-53-5
• 化学式: C₂₆H₁₈Br₂CoN₂O₂
• 分子量: 609.242
• InChiKey: UMBRTWSPWWAULN-CGZWKZIFSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  bis(2-{(E)-[(4-bromophenyl)imino]methyl}phenolate)cobalt(II) 在 air 作用下， 生成 cobalt(III) oxide 、 一氧化碳 、 氮 、 氢气
  参考文献：
  名称：

  Synthesis and distinct urease enzyme inhibitory activities of metal complexes of Schiff-base ligands: Kinetic and thermodynamic parameters evaluation from TG-DTA analysis

  摘要：

  Transition metal [Co, Ni, Cu and Zn(II) acetates] complexes of salicylaldehyde derived Schiff bases, 2-{(E)-[(4-chlorophenyl)imino]methyl}phenol (CIMP) and 2-{(E)-[(4-bromophenyl)imino]methyl}phenol (BIMP) were synthesized and characterized by various analytical and spectroscopic studies. The Schiff base ligands and their metal complexes were also screened for their urease, alpha-chymotrypsin, acetylcholinesterse and butyrylcholinesterase inhibition activities. The ligands were found active against alpha-chymotrypsin with IC50 +/- S.E.M. = 305.0 +/- 3.2 and 330.6 +/- 1.6 mu M respectively. The copper complexes of both the ligands were found active in inhibiting urease enzyme with IC50 +/- S.E.M.=10.7 +/- 0.2 and 5.0 +/- 0.1 mu M respectively, as compared to standard inhibitor. Structure activity relationship (SAR) was evaluated using autodock programme. It was found that the active complexes block the entrance cavity to the enzyme. All the complexes were evaluated for their thermal degradation studies using TG-DTA analytical methods in static air. Thermodynamic and kinetic parameters were evaluated from the TG/DTA curves using Horowitz-Metzger method. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.tca.2012.12.023
• 作为产物：
  描述：

  水杨醛 在 硫酸 作用下， 以 甲醇 、 乙醇 为溶剂， 生成 bis(2-{(E)-[(4-bromophenyl)imino]methyl}phenolate)cobalt(II)
  参考文献：
  名称：

  Synthesis and distinct urease enzyme inhibitory activities of metal complexes of Schiff-base ligands: Kinetic and thermodynamic parameters evaluation from TG-DTA analysis

  摘要：

  Transition metal [Co, Ni, Cu and Zn(II) acetates] complexes of salicylaldehyde derived Schiff bases, 2-{(E)-[(4-chlorophenyl)imino]methyl}phenol (CIMP) and 2-{(E)-[(4-bromophenyl)imino]methyl}phenol (BIMP) were synthesized and characterized by various analytical and spectroscopic studies. The Schiff base ligands and their metal complexes were also screened for their urease, alpha-chymotrypsin, acetylcholinesterse and butyrylcholinesterase inhibition activities. The ligands were found active against alpha-chymotrypsin with IC50 +/- S.E.M. = 305.0 +/- 3.2 and 330.6 +/- 1.6 mu M respectively. The copper complexes of both the ligands were found active in inhibiting urease enzyme with IC50 +/- S.E.M.=10.7 +/- 0.2 and 5.0 +/- 0.1 mu M respectively, as compared to standard inhibitor. Structure activity relationship (SAR) was evaluated using autodock programme. It was found that the active complexes block the entrance cavity to the enzyme. All the complexes were evaluated for their thermal degradation studies using TG-DTA analytical methods in static air. Thermodynamic and kinetic parameters were evaluated from the TG/DTA curves using Horowitz-Metzger method. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.tca.2012.12.023

文献信息

• trans-Bis[N-(4-bromophenyl)salicylaldiminato]cobalt(II)
  作者：A. Elmali、Y. Elerman、I. Svoboda、H. Fuess

  DOI：10.1107/s0108270195011875

  日期：1996.3.15

  In the title compound, trans-bis[2-(4-bromophenyl-iminomethyl) phenolate-N,O]cobalt(II), [CO(C13H9Br-NO)(2)], the Co atom is situated on a twofold axis and the geometry around the metal centre can be described as distorted tetrahedral with a trans conformation. The Co-O and Co-N bond lengths are 1.891(3) and 2.006 (4) Angstrom, respectively.