甲氧基-乙酸甲基酰胺 | 57270-75-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 甲氧基-乙酸甲基酰胺
• 英文名称: Methoxyessigsaeure-monomethylamid
• 英文别名: methoxy-acetic acid methylamide；Methoxy-essigsaeure-methylamid；2-Methoxy-N-methyl-acetamid；methoxymethyl-N-methyl-formamide；N,O-dimethylhydroxylacetamide；N-methyl 2-methoxyacetamide；2-methoxy-N-methylacetamide
• CAS: 57270-75-4
• 化学式: C₄H₉NO₂
• mdl: MFCD19595577
• 分子量: 103.121
• InChiKey: DYJPVSYLWLJPEE-UHFFFAOYSA-N

物化性质

• 沸点：
  227.2±23.0 °C(Predicted)
• 密度：
  0.964±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  甲氧基-乙酸甲基酰胺 在 lithium aluminium tetrahydride 、 乙醚 作用下， 生成 N-(2-甲氧基乙基)甲基胺
  参考文献：
  名称：

  Mndshojan et al., Doklady Akademii Nauk Armyanskoi SSR, 1958, vol. 27, p. 179,182

  摘要：

  DOI：
• 作为产物：
  描述：

  N-甲氧基-N-甲基-2-甲氧基乙酰胺 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 反应 0.08h， 以73%的产率得到甲氧基-乙酸甲基酰胺
  参考文献：
  名称：

  A new mode of reactivity of N-methoxy-N-methylamides with strongly basic reagents

  摘要：

  DOI：

  10.1016/s0040-4039(00)97039-4

文献信息

• Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors
  作者：Weiya Yun、Mushtaq Ahmad、Yingsi Chen、Paul Gillespie、Karin Conde-Knape、Sonja Kazmer、Shiming Li、Yimin Qian、Rebecca Taub、Stanley J. Wertheimer、Toni Whittard、David Bolin

  DOI：10.1016/j.bmcl.2011.09.039

  日期：2011.12

  In a discovery effort to find safe and effective DGAT-1 inhibitors, we have identified 2-phenyloxazole 4-carboxamide 1 as a conformationally constrained analog of a hydrazide hit, which was previously identified from high-throughput screening. Further optimization of this series has led to chemically more stable 2-phenyloxazole-based DGAT-1 inhibitor 25 with improved solubility, cell-based activity

  在寻找安全有效的DGAT-1抑制剂的发现工作中，我们已将2-苯基恶唑4-羧酰胺1确定为酰肼命中的构象受限类似物，先前已从高通量筛选中鉴定出了这种化合物。该系列的进一步优化已导致化学上更稳定的基于2-苯基恶唑的DGAT-1抑制剂25，具有改善的溶解度，基于细胞的活性和药代动力学特性。化合物25还在饮食诱导的肥胖症（DIO）大鼠模型中证明了体内功效。
• Heteroaryl substituted phenylethenyl compounds having retinoid-like
  申请人：Allergan, Inc.

  公开号：US05391753A1

  公开（公告）日：1995-02-21

  Compounds of the formula ##STR1## where R.sub.1, R.sub.2, R.sub.3 and R.sub.4 independently are hydrogen, lower alkyl of 1-6 carbons, halogen or lower alkoxy of 1-6 carbons; R.sub.5 and R.sub.5 ' independently are hydrogen or lower alkyl of 1-6 carbons; Y is oxygen or sulfur; Z is n-alkyl having 1-10 carbons, cyclo or branch-chained alkyl of 3-10 carbons, and straight chain alkenyl having 2-10 carbons, or cyclo or branched chained alkenyl of 3-10 carbons; X is thienyl, pyridyl, furyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl and oxazolyl; A is (CH.sub.2).sub.n where n is 0-5, lower branched chain alkyl having 3-6 carbons, cycloalkyl having 3-6 carbons, alkenyl having 2-6 carbons and 1 or 2 double bonds, alkynyl having 2-6 carbons and 1 or 2 triple bonds; B is hydrogen, COOH or a pharmaceutically acceptable salt thereof, COOR.sub.8, CONR.sub.9 R.sub.10, --CH.sub.2 OH, CH.sub.2 OR.sub.11, CH.sub.2 OCOR.sub.11, CHO, CH(OR.sub.12).sub.2, CHOR.sub.13 O, --COR.sub.7, CR.sub.7 (OR.sub.12).sub.2, or CR.sub. 7 OR.sub.13 O, where R.sub.7 is an alkyl, cycloalkyl or alkenyl group containing 1-5 carbons, R.sub.8 is an alkyl group of 1-10 carbons, or a cycloalkyl group of 5-10 carbons, or R.sub.8 is phenyl or lower alkylphenyl, R.sub.9 and R.sub.10 independently are hydrogen, an alkyl group of 1-10 carbons, or a cycloalkyl group of 5-10 carbons, or phenyl or lower alkylphenyl, R.sub.11 is alkyl of 1-10 carbons, phenyl or lower alkylphenyl, R.sub.12 is lower alkyl, and R.sub.13 is divalent alkyl radical of 2-5 carbons, have retinoic acid like biological activity.

  化合物的公式为##STR1##其中R.sub.1，R.sub.2，R.sub.3和R.sub.4独立地是氢，1-6个碳的低级烷基，卤素或1-6个碳的低级烷氧基；R.sub.5和R.sub.5'独立地是氢或1-6个碳的低级烷基；Y是氧或硫；Z是n-烷基，具有1-10个碳，环或分支链烷基，具有3-10个碳，并且直链烯基具有2-10个碳，或环或分支链烯基具有3-10个碳；X是噻吩基，吡啶基，呋喃基，吡嗪基，嘧啶基，吡咯烷基，噻唑基和噁唑基；A是（CH.sub.2）.sub.n，其中n为0-5，低支链烷基，具有3-6个碳，具有3-6个碳的环烷基，具有2-6个碳和1或2个双键的烯基，具有2-6个碳和1或2个三键的炔基；B是氢，COOH或其药学上可接受的盐，COOR.sub.8，CONR.sub.9 R.sub.10，--CH.sub.2 OH，CH.sub.2 OR.sub.11，CH.sub.2 OCOR.sub.11，CHO，CH（OR.sub.12）.sub.2，CHOR.sub.13 O，--COR.sub.7，CR.sub.7（OR.sub.12）.sub.2，或CR.sub.7 OR.sub.13 O，其中R.sub.7是含有1-5个碳的烷基，环烷基或烯基，R.sub.8是1-10个碳的烷基，或5-10个碳的环烷基，或R.sub.8是苯基或低级烷基苯基，R.sub.9和R.sub.10独立地是氢，1-10个碳的烷基，或5-10个碳的环烷基，或苯基或低级烷基苯基，R.sub.11是1-10个碳的烷基，苯基或低级烷基苯基，R.sub.12是低级烷基，R.sub.13是2-5个碳的双价烷基基团，具有类似于视黄酸的生物活性。
• GRAHAM, SAMUEL E.;SCHOLZ, THOMAS H., TETRAHEDRON LETT., 31,(1990) N4, C. 6269-6272
  作者：GRAHAM, SAMUEL E.、SCHOLZ, THOMAS H.

  DOI：——

  日期：——
• Mndshojan et al., Doklady Akademii Nauk Armyanskoi SSR, 1958, vol. 27, p. 179,182
  作者：Mndshojan et al.

  DOI：——

  日期：——
• A new mode of reactivity of N-methoxy-N-methylamides with strongly basic reagents
  作者：Samuel L. Graham、Thomas H. Scholz

  DOI：10.1016/s0040-4039(00)97039-4

  日期：1990.1