N-(4-(2-(6-二甲基氨基)苯并呋喃基)苯基)马来酰亚胺 | 101046-20-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 中文名称: N-(4-(2-(6-二甲基氨基)苯并呋喃基)苯基)马来酰亚胺
• 英文名称: N-phenyl>maleimide
• 英文别名: N-<4-(6-dimethylamino-2-benzofuranyl)phenyl>maleimide；N-{p-[2-(6-dimethylamino)benzofuranyl]phenyl}maleimide；N-(4-(2-(6-Dimethylamino)benzofuranyl)phenyl)maleimide；1-[4-[6-(dimethylamino)-1-benzofuran-2-yl]phenyl]pyrrole-2,5-dione
• CAS: 101046-20-2
• 化学式: C₂₀H₁₆N₂O₃
• 分子量: 332.359
• InChiKey: JQJNRLOLSDAAPI-UHFFFAOYSA-N

物化性质

• 熔点：
  203-204 °C(Solv: acetone (67-64-1))
• 沸点：
  528.8±40.0 °C(Predicted)
• 密度：
  1.327±0.06 g/cm3(Predicted)
• 稳定性/保质期：

  遵照规定使用和储存，则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  53.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-羟基-N,N-二甲基苯胺 在 氢氧化钾 、 三氯化铝 、 sodium methylate 、 sodium acetate 、 三氯化铁 、 甲烷 、 肼 作用下， 以 甲醇 、 乙醇 、 氯仿 、 乙酸酐 、 苯 为溶剂， 反应 20.5h， 生成 N-(4-(2-(6-二甲基氨基)苯并呋喃基)苯基)马来酰亚胺
  参考文献：
  名称：

  Development and Application of Organic Reagents for Analysis. VI. Synthesis and Fluorescence Spectral Properties of 2-(4-Substituted phenyl)benzofurans

  摘要：

  合成了十五种2-(4-取代苯基)苊烯类化合物（4n），并研究了它们的荧光光谱特性，以评估其作为分析用有机试剂的适用性。

  DOI：

  10.1246/bcsj.58.2192

文献信息

• Hydrophobically-modified protein compositions and methods
  申请人：Pepinsky Blake R.

  公开号：US20050119181A1

  公开（公告）日：2005-06-02

  Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or a peptide. Alternatively, the protein can be derivatized by a wide variety of chemical reactions that append a hydrophobic structure to the protein. The preferred protein is of mammalian origin and is selected from the group consisting of Sonic, Indian, and Desert hedgehog. The hydrophobic moiety is used as a convenient tether to which may be attached a vesicle such as a cell membrane, liposome, or micelle.

  描述了一种水疏性修饰蛋白质及其制备方法。将一种疏水基团附加到蛋白质的表面氨基酸残基上。该疏水基团可以是脂质或肽。或者，可以通过各种化学反应使蛋白质衍生出一个疏水结构。优选的蛋白质是哺乳动物来源的，并从Sonic，Indian和Desert hedgehog组中选择。该疏水基团可用作方便的系链，可附着细胞膜、脂质体或微胶束等载体。
• Methods and compositions for treating disorders involving excitotoxicity
  申请人：Galdes Alphonse

  公开号：US20080221037A1

  公开（公告）日：2008-09-11

  It is shown here that hedgehog polypeptides possess novel activities beyond phenotype specification. Using cultures derived from the embryonic day 14.5 (E14.5) rat ventral mesencephalon, we show that hedgehog is also trophic for dopaminergic neurons and other neurons which are sensitive to exotoxicity.

  这里显示出刺猬多肽具有超出表型规范的新颖活性。使用从胚胎第14.5天（E14.5）大鼠腹侧中脑衍生的培养基，我们展示了刺猬对多巴胺能神经元和其他对外毒性敏感的神经元也具有营养作用。
• METHODS FOR DETECTING SULFHYDRYL-CONTAINING COMPOUNDS IN A BIOLOGICAL TEST SAMPLE
  申请人：Dai Yuqin

  公开号：US20100099134A1

  公开（公告）日：2010-04-22

  The invention relates to methods for detecting the presence of a compound of formula I in a biological test sample: where R 2 , R 3 , and R 4 are as defined in the specification; or a salt thereof.

  该发明涉及一种检测生物测试样品中化合物I的存在的方法：其中R2、R3和R4如规范中所定义；或其盐。
• INDICATOR FOR ASSESSING BODY ODOR, PROCESS FOR PRODUCING THE SAME, BODY ODOR ASSESSMENT METHOD, METHOD OF ASSESSING EFFICACIOUSNESS OF DEODORANT AND KIT FOR CONVENIENTLY ASSESING BODY ODOR
  申请人：Kao Corporation

  公开号：EP1553411A1

  公开（公告）日：2005-07-13

  An indicator material for assessing body odor of the present invention comprises at least one member selected from the group consisting of a substance (A) which is a β-hydroxycarboxylic acid compound represented by the formula (1), a substance (B) which is a derivative of the compound represented by the formula (1), a substance (C) which is an alcohol compound having a mercapto group at the 3-position represented by the formula (2),and a substance (D) which is a derivative of the compound represented by the formula (2). The present invention also provides a method of producing the compound represented by the formula (2) by incubating perspiration originated from a human in an environment with an oxygen concentration of 10 v/v% or less. The present invention also provides a kit for assessing body odor of a human, wherein the kit for assessing body odor of a human includes a coloration reagent which reacts with β-hydroxycarboxylic acid originated from perspiration of a human. wherein R1 is an alkyl having 1 to 4 carbons; R2 is a hydrogen atom or an alkyl having 1 to 4 carbons, and the total number of carbons in the formula (1) is 10 or less; wherein R3 is a hydrogen atom or methyl group; R4 is an alkyl group having 1 to 3 carbons; and R5 is a hydrogen atom or a methyl group, the total number of carbons is 8 or less.

  本发明的一种用于评估体味的指示剂材料包括至少一种选自以下组成的成员：一种物质（A），它是β-羟基羧酸化合物，由式（1）表示；一种物质（B），它是由式（1）表示的化合物的衍生物；一种物质（C），它是由式（2）表示的在3-位上具有巯基的醇化合物；以及一种物质（D），它是由式（2）表示的化合物的衍生物。本发明还提供了一种通过在氧气浓度为 10 v/v% 或更低的环境中培养人的汗液来生产式（2）所代表的化合物的方法。本发明还提供了一种用于评估人的体味的试剂盒，其中用于评估人的体味的试剂盒包括一种与源自人的汗液的β-羟基羧酸反应的着色试剂。 其中 R1 是具有 1 至 4 个碳原子的烷基；R2 是氢原子或具有 1 至 4 个碳原子的烷基，且式（1）中的碳原子总数为 10 或更少； 其中 R3 是氢原子或甲基；R4 是具有 1 至 3 个碳原子的烷基；R5 是氢原子或甲基，碳原子总数为 8 或更少。
• Netrin-related compositions and uses
  申请人：University of Utah Research Foundation

  公开号：EP2359842A1

  公开（公告）日：2011-08-24

  The present invention relates to a polypeptide effective to promote angiogenesis for use in promoting angiogenesis, wherein said polypeptide is a netrin polypeptide.

  本发明涉及一种有效促进血管生成的多肽，用于促进血管生成，其中所述多肽是一种净蛋白多肽。