2,4-dimethyl furan-2,4-dicarboxylate | 1710-13-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: 2,4-dimethyl furan-2,4-dicarboxylate
• 英文别名: dimethyl furan-2,4-dicarboxylate；dimethyl 2,4-furandicarboxylate；dimethyl furan-2,4-dioate；furan-2,4-dicarboxylic acid dimethyl ester；Furan-2,4-dicarbonsaeure-dimethylester；dimethyl furan-3,5-dicarboxylate
• CAS: 1710-13-0
• 化学式: C₈H₈O₅
• 分子量: 184.149
• InChiKey: GZNZEMZRQVMDDH-UHFFFAOYSA-N

物化性质

• 熔点：
  104-107 °C
• 沸点：
  265.3±20.0 °C(Predicted)
• 密度：
  1.244±0.06 g/cm3(Predicted)
• 保留指数：
  1365

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  65.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,4-dimethyl furan-2,4-dicarboxylate 在 甲醇 、 氢氧化钾 作用下， 生成 Furan-2-carbonsaeure-4-carbonsaeuremethylester
  参考文献：
  名称：

  Orientation in the Furan Nucleus. III. 5-Methyl-3-furoic Acid¹

  摘要：

  DOI：

  10.1021/ja01328a059
• 作为产物：
  描述：

  4-甲酰基呋喃-2-甲酸甲酯 在 sodium chlorite 、 sodium dihydrogenphosphate 、 2-甲基-2-丁烯 作用下， 以 四氢呋喃 、 水 、 叔丁醇 为溶剂， 反应 4.0h， 生成 2,4-dimethyl furan-2,4-dicarboxylate
  参考文献：
  名称：

  The Scent of Bacteria: Headspace Analysis for the Discovery of Natural Products

  摘要：

  Volatile compounds released by 50 bacterial strains, 45 of them actinobacteria in addition to three chloroflexi and two myxobacteria, have been collected by use of a closed-loop stripping apparatus, and the obtained headspace extracts have been analyzed by GC-MS. Excluding terpenes that have recently been published elsewhere, 254 compounds from all kinds of compound classes have been identified. For unambiguous compound identification several reference compounds have been synthesized. Among the detected volatiles 12 new natural products have been found, in addition to mellein, which was released by Saccharopolyspora erythraea. The iterative PKS for this compound has recently been identified by in vitro experiments, but mellein production in S. erythraea has never been reported before. These examples demonstrate that headspace analysis is an important tool for the discovery of natural products that may be overlooked using conventional techniques. The method is alos useful for feeding experiments with isotopically labeled precursors and was applied to investigate the biosynthesis of the unusual nitrogen compound 1-nitro-2-methylpropane, which arises from valine. Furthermore, several streptomycetes emitted compounds that were previously recognized as insect pheromones, thus questioning if bacterial symbionts are involved in insect communication.

  DOI：

  10.1021/np300468h

文献信息

• Substituted alkylamine derivatives
  申请人：Banyu Pharmaceutical Co., Ltd.

  公开号：US05234946A1

  公开（公告）日：1993-08-10

  The substituted alkylamine derivatives represented by formula (I) ##STR1## wherein R.sup.1 represents (a) substituted or unsubstituted C.sub.2-6 alkenyl group, (b) substituted or unsubstituted C.sub.3-6 cycloalkenyl group, (c) substituted or unsubstituted C.sub.2-6 alkynyl group, (d) substituted or unsubstituted aryl group, (e) substituted or unsubstituted heterocyclic group, (f) fused heterocyclic group which may be substituted, or (g) group represented by the formula Ru.sup.11 -Ar wherein R.sup.11 is a heterocyclic group and Ar is a 5- or 6-membered aromatic ring which may contain a hetero N, O or S atom, and which may be substituted; ##STR2## represents a 5- or 6-membered aromatic ring which may contain a hetero N, O or S atom, and may be substituted by R.sup.7, X and Y are linking groups, R.sup.2 is H or lower alkyl, R.sup.3 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl or lower cycloalkyl, R.sup.4 and R.sup.5 are independently hydrogen or halogen atoms, R.sup.6 represents (a) substituted or unsubstituted acyclic hydrocarbon group which may be unsaturated, (b) substituted or unsubstituted cycloalkyl group, or (c) substituted or unsubstituted phenyl group, or non-toxic salts thereof. (E)-N-(6-6-dimethyl-2-hepten-4-ynyl)-N-ethyl-3-[4-(3-thienyl)-2-thienyl-me thyloxy]benzylamine hydrochloride is a representative example. The substituted alkylamine derivatives are useful as pharmaceuticals, particularly for the treatment and prevention of hypercholesterolemia, hyperlipemia and arteriosclerosis.

  根据您的要求，以下是公式(I)所代表的取代烷基胺衍生物的中文翻译： “式中，R1 代表（a）取代或未取代的C2-6烯基团，（b）取代或未取代的C3-6环烯基团，（c）取代或未取代的C2-6炔基团，（d）取代或未取代的芳基团，（e）取代或未取代的杂环团，（f）可能被取代的融合杂环团，或（g）由公式Ru11-Ar表示的团，其中R11是杂环团，Ar是5或6成员的芳香环，其中可能含有杂N、O或S原子，并且可能被取代；##STR2##代表一个5或6成员的芳香环，其中可能含有杂N、O或S原子，并且可能被R7、X和Y是连接基团，R2是H或低级烷基，R3是氢、低级烷基、低级烯基、低级炔基或低级环烷基，R4和R5是独立的是氢或卤素原子，R6代表（a）可能是不饱和的取代或未取代的链状烃基团，（b）取代或未取代的环烷基团，或（c）取代或未取代的苯基团，或其非毒性的盐。以下是一个代表性的例子：(E)-N-(6-6-二甲基-2-庚烯-4-炔基)-N-乙基-3-[4-(3-噻吩基)-2-噻吩基甲氧基]苄胺盐酸盐。这些取代烷基胺衍生物作为药物很有用，特别适用于治疗和预防高胆固醇血症、高脂血症和动脉粥样硬化。”
• MODIFIER FOR AROMATIC POLYESTER AND AROMATIC POLYESTER RESIN COMPOSITION COMPRISING THE SAME
  申请人：TABATA Masayoshi

  公开号：US20110224343A1

  公开（公告）日：2011-09-15

  The present invention provides a modifier for aromatic polyesters which enhances the melt fluidity of aromatic polyesters without a significant decrease in the heat resistance of the aromatic polyesters, and an aromatic polyester resin composition including the modifier for aromatic polyesters. The present invention relates to a modifier for aromatic polyesters comprising polyhydric phenol residues and residues of aromatic polycarboxylic acid, acid halide or acid anhydride thereof, and the modifier comprises a material having a structure composed of a first residue selected from the group consisting of divalent residues represented by Formula (I): —Ar—W 1 x —Ar— and by Formula (II): —Ar—, the first residues being bonded to two identical or different second residues selected from the group consisting of monovalent residues represented by Formula (III): and monovalent residues represented by Formula (IV): —O—C(O)—R 7 —.

  本发明提供了一种用于芳香族聚酯的改性剂，可以增强芳香族聚酯的熔融流动性，而不明显降低芳香族聚酯的耐热性，以及包括该改性剂的芳香族聚酯树脂组合物。本发明涉及一种用于芳香族聚酯的改性剂，包括多羟基酚残基和芳香族多羧酸、酸卤或其酸酐残基，该改性剂包括具有以下结构的材料：第一残基，选择自由式(I)所代表的二价残基：—Ar—W1x—Ar—和自由式(II)所代表的：—Ar—，第一残基与选择自由式(III)所代表的单价残基：和自由式(IV)所代表的单价残基：—O—C(O)—R7—的两个相同或不同的第二残基结合。
• [EN] PRODUCTION AND USE OF PLASTICIZERS BASED ON 2,4-ISOMER OF FURANDICARBOXYLIC ACID DIESTERS<br/>[FR] PRODUCTION ET UTILISATION DE PLASTIFIANTS À BASE DE 2,4-ISOMÈRE DE DIESTERS D'ACIDE FURANEDICARBOXYLIQUE
  申请人：BRASKEM SA

  公开号：WO2021240471A1

  公开（公告）日：2021-12-02

  The present disclosure generally relates to a compound of dialkyl ester of 2,4-furandicarboxylic acid, a method of preparing the compound, a polymer composition comprising a polymer and the compound, a method of preparing the polymer composition, a polymer product comprising the polymer composition and a method of using the compound as a plasticizer in the polymer product. The dialkyl ester of 2,4-furandicarboxylic acid of the present disclosure has greater plasticizing efficiency in a polymer composition that that of the standard phthalate and terephthalate-based plasticizers. The polymer product plasticized with the dialkyl ester of 2,4-furandicarboxylic acid may have improved flexibility, durability, processability and safety as compared to the same polymer product plasticized with conventional phthalate and terephthalate-based plasticizers.

  本公开涉及一种二烷基对呋二甲酸酯化合物，一种制备该化合物的方法，包括聚合物和该化合物的聚合物组合物，制备该聚合物组合物的方法，包括聚合物组合物的聚合物产品，以及将该化合物用作聚合物产品中的增塑剂的方法。本公开的二烷基对呋二甲酸酯化合物在聚合物组合物中具有更高的增塑效率，超过了标准邻苯二甲酸酯和对苯二甲酸酯基增塑剂。使用本公开的二烷基对呋二甲酸酯化合物增塑的聚合物产品可能具有比使用传统邻苯二甲酸酯和对苯二甲酸酯基增塑剂增塑的相同聚合物产品更好的柔韧性、耐久性、加工性和安全性。
• Concurrent formation of furan-2,5- and furan-2,4-dicarboxylic acid: unexpected aspects of the Henkel reaction
  作者：Shanmugam Thiyagarajan、Aliaksei Pukin、Jacco van Haveren、Martin Lutz、Daan S. van Es

  DOI：10.1039/c3ra42457j

  日期：——

  The concurrent formation of furan-2,5- and furan-2,4-dicarboxylic acid under solvent free conditions via a disproportionation reaction is described. By reacting potassium-2-furoate at 260 °C in the presence of 22 mol% of (Lewis acidic) catalysts like CdI2 or ZnCl2, potassium-2-furoate is disproportionated to furan and furandicarboxylic acids. Besides furan and furan-2,5-dicarboxylic acid (2,5-FDCA) as the main products, furan-2,4-dicarboxylic acid (2,4-FDCA) is also formed as a by-product. Experimental evidence has been obtained that, under the reaction conditions applied, 2,5-FDCA and 2,4-FDCA are formed by separate reaction pathways. Selectivity towards the different FDCA isomers is affected by the type of catalyst used. Single-crystal X-ray analysis shows that 2,4-FDCA has a more ‘linear’ character compared to 2,5-FDCA and hence is structurally more comparable to terephthalic acid (TA), making it an interesting monomer for synthetic polyesters.

  介绍了在无溶剂条件下通过歧化反应同时生成呋喃-2,5-和呋喃-2,4-二羧酸的过程。在 22 摩尔%（路易斯酸）催化剂（如 CdI2 或 ZnCl2）存在下，2-糠酸钾在 260 °C 下发生反应，歧化生成呋喃和呋喃二甲酸。除了主要产物呋喃和呋喃-2,5-二羧酸（2,5-FDCA）外，副产物还有呋喃-2,4-二羧酸（2,4-FDCA）。实验证明，在所采用的反应条件下，2,5-FDCA 和 2,4-FDCA 是通过不同的反应途径生成的。对不同 FDCA 异构体的选择性受所用催化剂类型的影响。单晶 X 射线分析表明，与 2,5-FDCA 相比，2,4-FDCA 更具有 "线性 "特征，因此在结构上更类似于对苯二甲酸 (TA)，使其成为合成聚酯的有趣单体。
• Furan-polycarbonsäuren II. Die Furan-2,3,5-tricarbonsäure
  作者：T. Reichstein、A. Grüssner

  DOI：10.1002/hlca.19330160175

  日期：——

  No abstract is available for this article.

  本文没有摘要。