邻氨基苯硼酸盐酸盐 | 863753-30-4

• 物质功能分类: 化学试剂 - 有机试剂 - 硼酸
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 邻氨基苯硼酸盐酸盐
• 中文别名: 2-氨基苯硼酸盐酸盐
• 英文名称: 2-aminophenylboronic acid hydrochloride
• 英文别名: (2-aminophenyl)boronic acid;hydrochloride
• CAS: 863753-30-4
• 化学式: C₆H₈BNO₂*ClH
• 分子量: 173.407
• InChiKey: WPDASZCYRKGSTO-UHFFFAOYSA-N

物化性质

• 熔点：
  115-118°C

计算性质

• 辛醇/水分配系数(LogP)：
  -4.76
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  68.1
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 危险品标志：
  Xn
• 危险类别码：
  R22
• 海关编码：
  2931900090
• 安全说明：
  S22,S24/25
• 危险性防范说明：
  P280,P305+P351+P338
• 危险性描述：
  H302

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 2-Aminophenylboronic acid, HCl
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 2-Aminophenylboronic acid, HCl
CAS number: 863753-30-4

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C6H9BClNO2
Molecular weight: 173.4

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  邻氨基苯硼酸盐酸盐 在 chloro(1,5-cyclooctadiene)rhodium(I) dimer 、 ammonia borane 、 potassium hydroxide 作用下， 以 aq. phosphate buffer 、 甲苯 为溶剂， 反应 113.0h， 生成 (R)-2-(3',4'-dimethoxyphenethyl)-1,2,3,4-tetrahydroquinoline
  参考文献：
  名称：

  协同化学/生物催化合成生物碱四氢喹啉

  摘要：

  在2-取代的四氢喹啉的不对称合成中证明了互补的化学催化和生物催化转化的能力。通过收敛的一锅Rh（I）催化的烷基乙烯基酮和氨基苯基硼酸的加成/缩合序列合成了一系列外消旋四氢喹啉。此后，显示出所得的四氢喹啉是黄素依赖性酶环己胺氧化酶的底物，并且已证明在这些高价值目标上进行了制备规模的脱硫。

  DOI：

  10.1021/acscatal.8b01220

文献信息

• FLAP MODULATORS
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：US20150259357A1

  公开（公告）日：2015-09-17

  The present invention relates to compounds of Formula (I), or a form thereof, wherein ring A, R 1 , R 2 , R 3 , R 3 ′, L, W, and V are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention

  本发明涉及式（I）的化合物，或其形式，其中环A，R1，R2，R3，R3'，L，W和V如本文所定义，可用作FLAP调节剂。该发明还涉及包含式（I）化合物的药物组合物。制备和使用式（I）化合物的方法也属于本发明的范围。
• Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors
  作者：Colin R. O’Dowd、Matthew D. Helm、J. S. Shane Rountree、Jakub T. Flasz、Elias Arkoudis、Hugues Miel、Peter R. Hewitt、Linda Jordan、Oliver Barker、Caroline Hughes、Ewelina Rozycka、Eamon Cassidy、Keeva McClelland、Ewa Odrzywol、Natalie Page、Stephanie Feutren-Burton、Scarlett Dvorkin、Gerald Gavory、Timothy Harrison

  DOI：10.1021/acsmedchemlett.7b00512

  日期：2018.3.8

  potential involvement in oncogenic pathways as well as possible roles in both metabolic and immune disorders in addition to viral infections. Potent, novel, and selective inhibitors of USP7 have been developed using both rational and structure-guided design enabled by high-resolution cocrystallography. Initial hits were identified via fragment-based screening, scaffold-hopping, and hybridization exercises

  泛素特异性蛋白酶7（USP7，HAUSP）由于在调节Mdm2水平（进而调节p53）中的作用，已成为药物发现中的引人注目的靶标。由于USP7可能参与致癌途径以及除病毒感染外在代谢和免疫疾病中的可能作用，因此人们对USP7的兴趣也越来越高。USP7的强效，新型和选择性抑制剂已通过高分辨率共结晶技术的合理设计和结构指导设计得到开发。最初的命中是通过基于片段的筛选，支架跳跃和杂交练习来确定的。描述了两个不同的子系列以及相关的结构-活性关系趋势，以及旨在开发适用于体内化合物的初步努力实验。总体而言，这些发现将有助于进一步研究USP7的更广泛的生物学作用。
• [EN] BETA-LACTAMASE INHIBITORS<br/>[FR] INHIBITEURS DE BÊTA-LACTAMASE
  申请人：UNIV CALIFORNIA

  公开号：WO2013056163A1

  公开（公告）日：2013-04-18

  Disclosed herein inter alia are Boron containing compounds and methods for treating infections related to antibiotic resistant microorganisms.

  本公开涉及含硼化合物和治疗与抗生素耐药微生物相关感染的方法。
• Novel Hydroxylated Aromatic Compounds
  申请人：Aydt Ewald M.

  公开号：US20080207741A1

  公开（公告）日：2008-08-28

  Pharmaceutical compositions comprising at least one compound of the formula (I) and a pharmaceutically acceptable carrier which is useful in a medicine wherein the symbols and substituents have the following meaning —X— is e.g. and Y being e.g. or the pharmaceutically acceptable salts, esters or amides and prodrugs can be applied to modulate the in-vitro and in-vivo binding processes mediated by E-, P- or L-selectin binding.

  含有至少一个式(I)的化合物和药用可接受的载体的药物组合物，在药物中有用 其中符号和取代基具有以下含义 —X— 例如 Y 例如 或者药用可接受的盐、酯或酰胺和前药可以被应用来调节由E-、P-或L-选择素结合介导的体外和体内结合过程。
• Photochemical intramolecular amination for the synthesis of heterocycles
  作者：Shawn Parisien-Collette、Corentin Cruché、Xavier Abel-Snape、Shawn K. Collins

  DOI：10.1039/c7gc02261a

  日期：——

  formed in good to excellent yields via photochemical conversion of the corresponding substituted aryl azides under irradiation with purple LEDs in a continuous flow reactor. The experimental set-up is tolerant to UV-sensitive functional groups while affording diverse carbazoles, as well as an indole and pyrrole framework, in short reaction times. The photochemical method is presumed to progress through

  可以在良好地形成优异的产率多环杂环通过在连续流动反应器中的LED紫色辐射下相应的取代的芳基叠氮化的光化学转化。该实验装置可耐受紫外线敏感的官能团，同时在较短的反应时间内即可提供多种咔唑以及吲哚和吡咯骨架。推测光化学方法是通过与涉及过渡金属催化的叠氮化物活化的其他方法不同的机理来进行的。