2,2,9,9-tetramethyl-3,8-decanediol | 92318-65-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,2,9,9-tetramethyl-3,8-decanediol
• 英文别名: 2,2,9,9-tetramethyldecane-3,8-diol；2,2,9,9-tetramethyl-decane-3,8-diol；2,2,9,9-Tetramethyl-decan-3,8-diol
• CAS: 92318-65-5
• 化学式: C₁₄H₃₀O₂
• 分子量: 230.391
• InChiKey: WOZJGBUSPAWYDZ-UHFFFAOYSA-N

物化性质

• 熔点：
  117.6-118.3 °C
• 沸点：
  119-124 °C(Press: 3.5 Torr)
• 密度：
  0.901±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2,9,9-tetramethyl-3,8-decanediol 、 chromium(lll) acetate 生成 2,2,9,9-tetramethyl-decane-3,8-dione
  参考文献：
  名称：

  Fuson; Robinson, Journal of the American Chemical Society, 1940, vol. 62, p. 359

  摘要：

  DOI：
• 作为产物：
  描述：

  叔丁基氯化镁 、 己二酰氯 在 乙醚 作用下， 生成 2,2,9,9-tetramethyl-3,8-decanediol
  参考文献：
  名称：

  Fuson; Robinson, Journal of the American Chemical Society, 1940, vol. 62, p. 359

  摘要：

  DOI：

文献信息

• Arene-promoted lithiation of 1,n-dihaloalkanes (n=2–6): a comparative study
  作者：Abdeslam Abou、Francisco Foubelo、Miguel Yus

  DOI：10.1016/j.tet.2006.08.064

  日期：2006.10

  n-dichloroalkanes 3a (n=2–6) with an excess of lithium powder and a catalytic amount of 4,4′-di-tert-butylbiphenyl (DTBB; 2.5 mol %) in the presence of different carbonyl compounds [ButCHO, PhCHO, Et2CO, (CH2)4CO, (CH2)5CO, (CH2)7CO, (−)-menthone], in THF at −78 °C leads, after hydrolysis with water, to the expected 1,(n+2)-diols 4, yields being <25% for n=2, 3 and in the range of 45–79% for n=4–6. When the

  1，n-二氯烷烃3a（n = 2–6）与过量的锂粉和催化量的4,4'-二叔丁基联苯（DTBB; 2.5 mol％）在不同羰基存在下的反应化合物[卜吨CHO，苯甲醛，等2 CO，（CH 2）4 CO，（CH 2）5 CO，（CH 2）7 CO，（ - ） -薄荷酮]，在THF中在-78℃下引线，后用水水解，以期望的1，（ñ 2）-diols 4，产率是<25％ñ = 2，3和为45-79％的范围内ñ= 4–6。当相同的协议被施加到1，Ñ -bromochloroalkanes 3B和1，Ñ -dibromoalkanes 3C（Ñ = 2-6），二醇4在一般得到较低的产率。
• 3-Chloropropyl and 4-Chlorobutyl Phenyl Ethers as Sources of 1,3-Dilithiopropane and 1,4-Dilithiobutane:  Sequential Reaction with Carbonyl Compounds
  作者：Francisco Foubelo、Sadiq A. Saleh、Miguel Yus

  DOI：10.1021/jo000039m

  日期：2000.6.1

  The reaction of 3-chloropropyl and 4-chlorobutyl phenyl ethers (1) with lithium powder and a catalytic amount of DTBB (5% molar) in THF at -78 degrees C followed by successive treatment with a carbonyl compound [(RRCO)-R-1-C-2 = (BuCHO)-C-t, Me2CO, (CH2)(5)CO, (-)-menthone] at -78 to 20 degrees C and, after 1.5 h at this temperature, with a second one [(RRCO)-R-3-C-4 = (BuCHO)-C-t, PhCHO, Me2CO, MeCOPrn, (CH2)(5)CO, (-)-menthone] at -78 degrees C leads,after hydrolysis with water, to the corresponding 1,5- and 1,6-diols (2). Because of the competition of two different reductive cleavages, 1,4- and 1,5-diols 3 were also obtained as side-reaction products.
• Fuson; Robinson, Journal of the American Chemical Society, 1940, vol. 62, p. 359
  作者：Fuson、Robinson

  DOI：——

  日期：——