2,3-二溴-1-丁烯 | 52111-97-4

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 乙烯基卤化物
• 中文名称: 2,3-二溴-1-丁烯
• 英文名称: 2,3-dibromo-but-1-ene
• 英文别名: 2,3-Dibrom-but-1-en；β.γ-Dibrom-α-butylen；2,3-Dibromo-1-butene；2,3-dibromobut-1-ene
• CAS: 52111-97-4
• 化学式: C₄H₆Br₂
• 分子量: 213.9
• InChiKey: WXKJLTYKBGYLCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 海关编码：
  2903399090

反应信息

• 作为反应物：
  描述：

  2,3-二溴-1-丁烯 在 乙醇 、 锌 作用下， 生成 1,2-丁二烯
  参考文献：
  名称：

  Hurd; Meinert, Journal of the American Chemical Society, 1931, vol. 53, p. 293

  摘要：

  DOI：
• 作为产物：
  描述：

  1,2,3-三溴丁烷 在 氢氧化钾 作用下， 生成 2,3-二溴-1-丁烯
  参考文献：
  名称：

  Goldhahn, Pharmazie, 1953, vol. 8, p. 1016,1019

  摘要：

  DOI：

文献信息

• Guljajewa; Daugulewa, vol. 10, # 1, p. 53
  作者：Guljajewa、Daugulewa

  DOI：——

  日期：——
• Lespieau; Wiemann, Bulletin de la Societe Chimique de France, 1929, vol. <4>45, p. 628
  作者：Lespieau、Wiemann

  DOI：——

  日期：——
• Slobodin, Zhurnal Obshchei Khimii, 1935, vol. 5, p. 49
  作者：Slobodin

  DOI：——

  日期：——
• Chain Length Analysis of ADP-Ribose Polymers Generated by Poly(ADP-Ribose) Polymerase (PARP) as a Function of β-NAD+ and Enzyme Concentrations
  作者：Hilda Mendoza-Alvarez、Susana Chavez-Bueno、Rafael Alvarez-Gonzalez

  DOI：10.1080/15216540050212187

  日期：2000.8.1

  Bireactant autopoly(ADP-ribosyl)ation of poly(ADP-ribose) polymerase (PARP) (EC 2.4.2.30) was carried out by using either increasing concentrations of beta -NAD(+) (donor substrate) at a fixed protein concentration or increasing concentrations of PARP (acceptor substrate) at a fixed beta -NAD(+) concentration. The [P-32]ADP-ribose polymers synthesized were chemically detached from PARP by alkaline hydrolysis of the monoester bond between the carboxylate moiety of Glu and the polymer. Nucleic acid-like polymers were then analyzed by high-resolution polyacrylamide gel electrophoresis and autoradiography. The ADP-ribose chain lengths observed displayed substrate concentration-dependent elongation from 0.2 muM to 2 mM beta -NAD(+). Similar results were observed at fixed concentrations of 4.5, 9, 18, 27, and 36 nM PARP. Therefore, we conclude that the concentration of the ADP-ribose donor substrate determines the average chain length of the polymer synthesized. In contrast, the polymer size was unaltered when the concentration of PARP was varied from 4.5 to 18 nM at a fixed beta -NAD(+) concentration. However, when PARP concentrations >18 nM were used, the total amount of monomeric ADP-ribose produced was noticeably less. Therefore, we conclude that high concentrations of PARP lead to acceptor substrate inhibition at the level of the ADP-ribose chain initiation reaction.
• KURGINYAN K. A.; KALAJDZHEN A. E.; ROSTOMYAN I. M.; CHUXADZHYAN G. A., AJKAKAN KIMIAKAN AMSAGIR, ARM. XIM. ZH., 1981, 34, HO 5, 422-428
  作者：KURGINYAN K. A.、 KALAJDZHEN A. E.、 ROSTOMYAN I. M.、 CHUXADZHYAN G. A.

  DOI：——

  日期：——