Metal-Free Oxidative Decarbonylative Coupling of Aliphatic Aldehydes with Azaarenes: Successful Minisci-Type Alkylation of Various Heterocycles
作者:Ren-Jin Tang、Lei Kang、Luo Yang
DOI:10.1002/adsc.201500268
日期:2015.6.15
A metal‐free oxidative decarbonylative coupling of aliphatic aldehydes with various electron‐deficient heterocycles has been developed. This reaction is supposed to be realized via a Minisci‐type mechanism, based on the substrate scope, regioselectivity and radical trapping experiments. The ready availability of aliphatic aldehydes, metal‐free conditions and broad substrate scope should make this method
已经开发出脂肪族醛与各种电子不足的杂环的无金属氧化脱羰基偶联。根据底物范围,区域选择性和自由基捕获实验,该反应被认为是通过Minisci型机制实现的。脂肪醛的现成可用性,无金属条件和广泛的底物范围应使该方法对生物活性杂环的后期烷基化具有吸引力。