4-环己基哌嗪-1-胺 | 916518-99-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 4-环己基哌嗪-1-胺
• 英文名称: 4-cyclohexylpiperazin-1-amine
• 英文别名: 1-amino-4-cyclohexylpiperazine
• CAS: 916518-99-5
• 化学式: C₁₀H₂₁N₃
• 分子量: 183.297
• InChiKey: KLAFGNZLJAZPOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-环己基哌嗪-1-胺 、 2,4-二羟基苯甲醛 以 甲苯 为溶剂， 反应 2.0h， 以66%的产率得到(E)-4-((4-cyclohexylpiperazin-1-ylimino)methyl)benzene-1,3-diol
  参考文献：
  名称：

  Structure–activity studies in the development of a hydrazone based inhibitor of adipose-triglyceride lipase (ATGL)

  摘要：

  Adipose triglyceride lipase (ATGL) catalyzes the degradation of cellular triacylglycerol stores and strongly determines the concentration of circulating fatty acids (FAs). High serum FA levels are causally linked to the development of insulin resistance and impaired glucose tolerance, which eventually progresses to overt type 2 diabetes. ATGL-specific inhibitors could be used to lower circulating FAs, which can counteract the development of insulin resistance. In this article, we report about structure-activity relationship (SAR) studies of small molecule inhibitors of ATGL based on a hydrazone chemotype. The SAR indicated that the binding pocket of ATGL requests rather linear compounds without bulky substituents. The best inhibitor showed an IC50 = 10 mu M in an assay with COS7-cell lysate overexpressing murine ATGL. (C) 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

  DOI：

  10.1016/j.bmc.2015.02.051

文献信息

• [EN] NEW DRUGS WITH ANTICHOLESTATIC ACTIVITY<br/>[FR] NOUVEAUX MÉDICAMENTS À ACTION ANTI-CHOLESTATIQUE
  申请人：SEGIX ITALIA S R L

  公开号：WO2009010555A1

  公开（公告）日：2009-01-22

  New compounds belonging to the structural formula (I) are described. formula (I) in which R1, R2, A, Y and X are specified in the description, useful in the treatment of cholestasis and substantially devoid of antibacterial activity. The synthesis process of said compounds, the pharmaceutical compositions containing them and their use in therapy are also described.

  描述了属于结构式（I）的新化合物。 公式（I）中R1、R2、A、Y和X在描述中指定，适用于治疗胆汁淤积且基本上不具有抗菌活性。 还描述了这些化合物的合成过程、含有它们的药物组成物以及它们在治疗中的用途。
• DRUGS WITH ANTICHOLESTATIC ACTIVITY
  申请人：Brufani Mario

  公开号：US20100168129A1

  公开（公告）日：2010-07-01

  New compounds belonging to the structural formula (I) are described. in which R1, R2, A, Y and X are specified in the description, useful in the treatment of cholestasis and substantially devoid of antibacterial activity. The synthesis process of said compounds, the pharmaceutical compositions containing them and their use in therapy are also described.

  描述了属于结构式（I）的新化合物，其中R1、R2、A、Y和X在描述中有具体规定，适用于治疗胆汁淤积症且基本上不具有抗菌活性。还描述了所述化合物的合成过程、含有它们的药物组合物以及它们在治疗中的用途。
• Method for preserving quaternary ammonium salt
  申请人：——

  公开号：US20030153785A1

  公开（公告）日：2003-08-14

  A method of improving the stability of a quaternary ammonium salt and a method of efficiently preparing the quaternary ammonium salt having improved stability.

  一种提高季铵盐稳定性的方法和一种高效制备稳定性提高的季铵盐的方法。
• [EN] AROYLPIPERAZINES FOR MODULATING SEXUAL ACTIVITY<br/>[FR] AROYLPIPERAZINES DESTINEES A MODULER L'ACTIVITE SEXUELLE
  申请人：NORTRAN PHARMACEUTICALS INC.

  公开号：WO1999002159A1

  公开（公告）日：1999-01-21

  (EN) The present invention discloses that substituted acetic acid derivatives containing a N-alkylpiperazino moiety are useful as pro-libido agents for males and females, and may be used for the treatment of sexual dysfunction including impotence and to enhance sexual performance.(FR) La présente invention concerne des dérivés d'acide acétique contenant une fraction de N-alkylpipérazine, utilisés comme agents d'activation de la libido pour des animaux mâles et femelles. Lesdits dérivés peuvent être utilisés pour le traitement d'un dysfonctionnement sexuel comprenant l'impuissance et pour améliorer la performance sexuelle.

  (中) 本发明揭示了含有N-烷基哌嗪基团的取代乙酸衍生物可作为雄性和雌性的前性欲剂，并可用于治疗包括阳痿在内的性功能障碍以及增强性能力。(法) 本发明涉及含有N-烷基哌嗪基团的取代乙酸衍生物，可用作雄性和雌性的前性欲剂。这些衍生物可用于治疗包括阳痿在内的性功能障碍，并提高性能力。
• PROCESS FOR PRODUCING CARBOXYLIC ACID DERIVATIVE AND CONDENSING AGENT COMPRISING QUATERNARY AMMONIUM SALT
  申请人：TOKUYAMA CORPORATION

  公开号：EP1085000A1

  公开（公告）日：2001-03-21

  A process for producing a carboxylic acid derivative characterized by mixing a quaternary ammonium salt having a specific triazine ring in the molecule, a carboxylic acid compound, and a compound having a nucleophilic functional group to conduct the condensation reaction of the carboxylic acid compound with the compound having a nucleophilic functional group; and a condensing agent comprising the quaternary ammonium salt. By the process, the condensation reaction can be conducted under mild conditions and a carboxylic acid derivative, especially an amide or ester compound, can be obtained in high yield.

  一种生产羧酸衍生物的工艺，其特征在于将分子中含有特定三嗪环的季铵盐、羧酸化合物和具有亲核官能团的化合物混合，以进行羧酸化合物与具有亲核官能团的化合物的缩合反应；以及由季铵盐组成的缩合剂。通过该工艺，可在温和条件下进行缩合反应，并以高产率获得羧酸衍生物，特别是酰胺或酯类化合物。