CH3SCH2CH2OCH2COOEt

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: CH3SCH2CH2OCH2COOEt
• 英文别名: Ethyl 2-(2-methylsulfanylethoxy)acetate
• 化学式: C₇H₁₄O₃S
• 分子量: 178.252
• InChiKey: DPIXODHSWHQDCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  60.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  CH3SCH2CH2OCH2COOEt 在 lithium aluminium tetrahydride 、 水 、 potassium hydroxide 作用下， 以 乙醚 为溶剂， 反应 0.5h， 以2.1 g的产率得到2-(2-methylthioethoxy)ethanol
  参考文献：
  名称：

  Assessment of heat-sensitive thiophosphate protecting groups in the development of thermolytic DNA oligonucleotide prodrugs

  摘要：

  Heat-sensitive thiophosphate protecting groups derived from the alcohol 4 or 10 have provided insights in the design of DNA oligonucleotide prodrugs. Indeed, functional groups stemming from the alcohol 9, 15, 16 or 22 may be applicable to thiophosphate protection of immunostimulatory CpG DNA motifs, whereas those originating from the alcohol 3, 5,12,13,18, 20 or 22 offer adequate protection of terminal phosphodiester functions against ubiquitous exonucleases that may be found in biological environments. Functional groups derived from the alcohol 9, 15, 16, 19 or 23 are suitable for the protection of phosphodiester functions flanking the CpG motifs of immunomodulatory DNA sequences. Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2009.10.096
• 作为产物：
  描述：

  2-甲硫基乙醇 、 溴乙酸乙酯 在 sodium hydride 作用下， 以 乙二醇二甲醚 为溶剂， 反应 2.0h， 生成 CH3SCH2CH2OCH2COOEt
  参考文献：
  名称：

  Assessment of heat-sensitive thiophosphate protecting groups in the development of thermolytic DNA oligonucleotide prodrugs

  摘要：

  Heat-sensitive thiophosphate protecting groups derived from the alcohol 4 or 10 have provided insights in the design of DNA oligonucleotide prodrugs. Indeed, functional groups stemming from the alcohol 9, 15, 16 or 22 may be applicable to thiophosphate protection of immunostimulatory CpG DNA motifs, whereas those originating from the alcohol 3, 5,12,13,18, 20 or 22 offer adequate protection of terminal phosphodiester functions against ubiquitous exonucleases that may be found in biological environments. Functional groups derived from the alcohol 9, 15, 16, 19 or 23 are suitable for the protection of phosphodiester functions flanking the CpG motifs of immunomodulatory DNA sequences. Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2009.10.096

文献信息

• Colored curable composition, color filter and manufacturing method thereof
  申请人：Seto Nobuo

  公开号：US20090047585A1

  公开（公告）日：2009-02-19

  The present invention provides a compound represented by the following Formula (C1), or a colored curable composition containing a tetraazaporphyrin colorant having at least one group represented by the following Formula (I), and a color filter using the composition and a manufacturing method thereof: wherein Rc 1 : a halogen atom, aliphatic group, aryl group, heterocyclic group, cyano group, carboxyl group, carbamoyl group, aliphatic oxycarbonyl group, aryloxycarbonyl group, acyl group, hydroxyl group, aliphatic oxy group, aryloxy group, etc.; Zc 1 : a non-metal atom group necessary for forming a 6-membered ring together with the carbon atom; M: two hydrogen atoms, a divalent metal atom, divalent metal oxide, divalent metal hydroxide, divalent metal chloride; cm=0 to 2, cn=0, 1 to 5; cr1, cr2, cr3, cr4=0 to 1 (cr1+cr2+cr3+cr4≧1); L 1 : an alkylene group; A 1 and A 2 : —O—, —C(═O)—, —OC(═O)—, —C(═O)O—, —N(R 2 )C(═O)—, —C(═O)N(R 2 )—, —N(R 2 )C(═O)—, —OC(═O)N(R 2 )—, N(R 2 )C(═O)N(R 3 )—, —N(R 2 )SO 2 —, —SO 2 N(R 2 )—, or —SO 2 —; L 2 : an alkylene group, aralkylene group, or arylene group; n: an integer from 1 to 3; m: an integer from 0 to 3; R 1 : a hydrogen atom, alkyl group, aryl group or heterocyclic group; and R 2 and R 3 : a hydrogen atom, alkyl group, aryl group or heterocyclic group.
• US7842440B2
  申请人：——

  公开号：US7842440B2

  公开（公告）日：2010-11-30
• Assessment of heat-sensitive thiophosphate protecting groups in the development of thermolytic DNA oligonucleotide prodrugs
  作者：Cristina Ausín、Jon S. Kauffman、Robert J. Duff、Shankaramma Shivaprasad、Serge L. Beaucage

  DOI：10.1016/j.tet.2009.10.096

  日期：2010.1

  Heat-sensitive thiophosphate protecting groups derived from the alcohol 4 or 10 have provided insights in the design of DNA oligonucleotide prodrugs. Indeed, functional groups stemming from the alcohol 9, 15, 16 or 22 may be applicable to thiophosphate protection of immunostimulatory CpG DNA motifs, whereas those originating from the alcohol 3, 5,12,13,18, 20 or 22 offer adequate protection of terminal phosphodiester functions against ubiquitous exonucleases that may be found in biological environments. Functional groups derived from the alcohol 9, 15, 16, 19 or 23 are suitable for the protection of phosphodiester functions flanking the CpG motifs of immunomodulatory DNA sequences. Published by Elsevier Ltd.