2-methyl butanedioic acid 4-ethyl ester | 34861-78-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-methyl butanedioic acid 4-ethyl ester
• 英文别名: 4-ethoxy-2-methyl-4-oxobutanoic acid；4-ethoxy-2-methyl-4-oxobutyric acid；methyl-succinic acid-4-ethyl ester；Methyl-bernsteinsaeure-4-aethylester
• CAS: 34861-78-4
• 化学式: C₇H₁₂O₄
• 分子量: 160.17
• InChiKey: NMEQTRDRCUBKRO-UHFFFAOYSA-N

物化性质

• 熔点：
  176-177 °C(Solv: ethanol, 70% (64-17-5))
• 沸点：
  264.1±23.0 °C(Predicted)
• 密度：
  1.123±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-methyl butanedioic acid 4-ethyl ester 以87%的产率得到
  参考文献：
  名称：

  HIRATAKE, JUN;YAMAMOTO, KAZUYOSHI;YAMAMOTO, YUKIO;ODA, JUNICHI, TETRAHEDRON LETT., 30,(1989) N2, C. 1555-1556

  摘要：

  DOI：
• 作为产物：
  描述：

  3-甲基-4-氧代丁酸乙酯 在 air 、 cobalt(II) acetate 作用下， 生成 2-methyl butanedioic acid 4-ethyl ester
  参考文献：
  名称：

  Adkins; Krsek, Journal of the American Chemical Society, 1949, vol. 71, p. 3053

  摘要：

  DOI：

文献信息

• Photoinduced Hydrocarboxylation via Thiol-Catalyzed Delivery of Formate Across Activated Alkenes
  作者：Sara N. Alektiar、Zachary K. Wickens

  DOI：10.1021/jacs.1c07562

  日期：2021.8.25

  Herein we disclose a new photochemical process to prepare carboxylic acids from formate salts and alkenes. This redox-neutral hydrocarboxylation proceeds in high yields across diverse functionalized alkene substrates with excellent regioselectivity. This operationally simple procedure can be readily scaled in batch at low photocatalyst loading (0.01% photocatalyst). Furthermore, this new reaction can

  在此，我们公开了一种从甲酸盐和烯烃制备羧酸的新光化学方法。这种氧化还原中性的加氢羧化反应在多种功能化烯烃底物上以高产率进行，具有优异的区域选择性。这种操作简单的程序可以很容易地在低光催化剂负载（0.01% 光催化剂）下批量缩放。此外，这种新反应可以利用市售的甲酸盐碳同位素来直接合成同位素标记的羧酸。机理研究支持涉及硫醇催化自由基链过程的工作模型，其中来自甲酸盐的原子通过CO 2 •–作为关键的反应中间体传递穿过烯烃底物。
• Highly regioselective ring-opening of α- substituted cyclic acid anhydrides catalyzed by lipase
  作者：Jun Hiratake、Kazuyoshi Yamamoto、Yukio Yamamoto、Jun'ichi Oda

  DOI：10.1016/s0040-4039(00)99517-0

  日期：——

  Lipase Amano P irreversibly catalyzed a ring-opening of α-substituted cyclic acid anhydrides 1 preferentially at the less hindered carbonyl goup to give monoesters with high regioselectivity.

  脂肪酶Amano P不可逆地优先在受阻较小的羰基上催化α-取代的环状酸酐1的开环，从而得到具有高区域选择性的单酯。
• Hepatitis C Virus Inhibitors
  申请人：Bristol-Myers Squibb Company

  公开号：US20160311778A1

  公开（公告）日：2016-10-27

  The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

  本公开涉及化合物、组合物和方法，用于治疗丙型肝炎病毒（HCV）感染。还公开了含有这些化合物的制药组合物和使用这些化合物治疗HCV感染的方法。
• HEPATITIS C VIRUS INHIBITORS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20170320833A1

  公开（公告）日：2017-11-09

  The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

  本公开涉及化合物、组合物和方法，用于治疗丙型肝炎病毒（HCV）感染。还公开了含有这些化合物的制药组合物和使用这些化合物治疗HCV感染的方法。
• Inhibition of Hiv-1 Replication by Disruption of the Processing of the Viral Capsid-Spacer Peptide 1 Protein
  申请人：Salzwedel Karl

  公开号：US20080200550A1

  公开（公告）日：2008-08-21

  Inhibition of HIV-1 replication by disrupting the processing of the viral Gag capsid (CA) protein (p24) from the CA-spacer peptide 1 (SP1) protein precursor (p25) is disclosed. Amino acid sequences containing a mutation in the Gag p25 protein, with the mutation resulting in a decrease in the inhibition of processing of p25 to p24 by dimethylsuccinyl betulinic acid or dimethylsuccinyl betulin, polynucleotides encoding such mutated sequences and antibodies that selectively bind such mutated sequences are also included. Methods of inhibiting, inhibitory compounds and methods of discovering inhibitory compounds that target proteolytic processing of the HIV Gag protein are included. In one embodiment, such compounds inhibit the interaction of the HIV protease enzyme with Gag by binding to Gag rather than to the protease enzyme. In another embodiment, viruses or recombinant proteins that contain mutations in the region of the Gag proteolytic cleavage site can be used in screening assays to identify compounds that target proteolytic processing.

  抑制HIV-1繁殖的方法是通过破坏病毒Gag外壳蛋白（CA）蛋白（p24）从CA-间隔肽1（SP1）蛋白前体（p25）的处理来实现的。包括含有Gag p25蛋白中突变的氨基酸序列，该突变导致二甲基琥珀酰基齐墩果酸或二甲基琥珀酰基齐墩的p25到p24处理的抑制减少，编码这种突变序列的多核苷酸和选择性结合这种突变序列的抗体。还包括抑制方法、抑制化合物和发现靶向HIV Gag蛋白的蛋白酶解处理的抑制化合物的方法。在其中一种实施例中，这些化合物通过与Gag结合而不是与蛋白酶酶结合来抑制HIV蛋白酶酶与Gag的相互作用。在另一种实施例中，包含在Gag蛋白酶解割位区域中的突变病毒或重组蛋白可以用于筛选测定，以识别靶向蛋白酶解处理的化合物。