3-(pyrrol-1-yl)propionic acid 2,5-dioxopyrrolidin-1-yl ester | 171627-22-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 3-(pyrrol-1-yl)propionic acid 2,5-dioxopyrrolidin-1-yl ester
• 英文别名: (2,5-Dioxopyrrolidin-1-yl) 3-pyrrol-1-ylpropanoate
• CAS: 171627-22-8
• 化学式: C₁₁H₁₂N₂O₄
• 分子量: 236.227
• InChiKey: TWERSQQNFZUKKF-UHFFFAOYSA-N

物化性质

• 沸点：
  377.5±44.0 °C(Predicted)
• 密度：
  1.36±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  68.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  甘氨酰-L-亮氨酸 、 3-(pyrrol-1-yl)propionic acid 2,5-dioxopyrrolidin-1-yl ester 以 四氢呋喃 为溶剂， 反应 24.0h， 以75%的产率得到(S)-2-{2-[3-(1H-pyrrol-1-yl)-propanoylamino]acetamido}-4-methylpentanoic acid
  参考文献：
  名称：

  Novel magnetic core-shell polypyrrole-Fe3O4 nanoparticles functionalized by peptides or albumin

  摘要：

  Novel magnetic core-shell iron oxide nanoparticles, covered by polypyrrole which is functionalized by covalent attachment of glycyl-leucine or bovine serum albumin were synthesized using N-hydroxysuccinimide as activating reagent. The morphology of the functionalized magnetic nanoparticles was investigated by DLS and HRTEM, showing a core-shell structure. The structures of magnetic nanoparticles based on functionalized polypyrrole were investigated by FTIR spectroscopy and X-ray diffraction and the magnetic properties were determined by magnetization measurements.

  DOI：

  10.3998/ark.5550190.0011.a16
• 作为产物：
  描述：

  N-2-氰乙基吡咯 在 氢氧化钾 、 N,N'-二环己基碳二亚胺 作用下， 以 水 、 乙酸乙酯 为溶剂， 反应 1.0h， 生成 3-(pyrrol-1-yl)propionic acid 2,5-dioxopyrrolidin-1-yl ester
  参考文献：
  名称：

  New Approach to Rapid Generation and Screening of Diverse Catalytic Materials on Electrode Surfaces

  摘要：

  This paper describes a general approach to rapid generation and screening of catalytic materials on electrode surfaces. The properties of the corresponding polymers, including catalytic performance, can be modulated by varying the monomer feed ratios, monomer concentrations, and applied polymerization potential, Thus, the generation of the polymeric TEMPO (2,2,6,6-tetramethylpiperidin-1-yloxy) catalysts was performed by electrochemical copolymerization of 2,2'-bithiophene with the TEMPO catalyst precursors containing pyrrole side chains. A library of catalyst films was obtained over a wide range of bithiophene/pyrrole ratios upon repeated scanning of the applied potential from +0.5 to +1.4 V (vs Ag/AgCl). The resulting catalyst films were utilized in both chemical and electrochemical oxidation of primary alcohols to aldehydes.

  DOI：

  10.1021/ja002334u

文献信息

• The development of an ultra-sensitive electrochemical immunosensor using a PPyr-NHS functionalized disposable ITO sheet for the detection of interleukin 6 in real human serums
  作者：Elif Burcu Aydın、Muhammet Aydın、Mustafa Kemal Sezgintürk

  DOI：10.1039/d0nj03183f

  日期：——

  A label-free impedimetric immunosensor based on a conjugated poly(pyrrole N-hydroxy succinimide) (PPyr-NHS) polymer covered disposable indium tin oxide electrode (ITO) was fabricated for the ultrasensitive determination of interleukin 6 (IL 6) antigen. In this sensing platform, the PPyr-NHS polymer, which carried a number of succinimide groups on its end side, was used as a matrix material for the

  基于共轭聚吡咯N的无标记阻抗免疫传感器制备了覆盖有羟基的琥珀酰亚胺（PPyr-NHS）聚合物的一次性铟锡氧化物电极（ITO），用于超灵敏地测定白介素6（IL 6）抗原。在该传感平台中，首次在其端侧带有多个琥珀酰亚胺基团的PPyr-NHS聚合物用作基质材料。该合成的聚合物具有优异的生物相容性和良好的导电性。另外，利用该材料作为基质材料可直接固定用作生物识别元件的IL 6受体（IL6R）。通过电化学阻抗谱（EIS）和循环伏安法（CV）技术确认了工作电极的制备，IL 6R的成功附着以及IL6R和IL 6抗原之间的特异性相互作用。此外，在构造过程中，通过扫描电子显微镜（SEM），原子力显微镜（AFM），傅立叶变换红外光谱（FTIR）和拉曼光谱对工作电极表面进行了表征。采用阻抗分析法定量IL 6抗原。在优化的实验条件下，设计的传感平台可以检测到范围从0.03 pg mL的IL 6抗原-1至22.5 pg
• Electropolymerizable monomers and polymeric coatings on implantable devices prepared therefrom
  申请人：Domb J. Abraham

  公开号：US20060013850A1

  公开（公告）日：2006-01-19

  Conductive surfaces of e.g., implantable devices, coated with electropolymerized polymers having active substances attached thereto are disclosed. Electropolymerizable monomers designed and used for obtaining such conductive surfaces and processes, devices and methods for attaching the electropolymerized polymers to conductive surfaces are also disclosed. The polymers, processes and devices presented herein can be beneficially used in the preparation of implantable medical devices.

  本发明揭示了涂有附着有活性物质的电聚合聚合物的可植入设备等导电表面。还揭示了设计和用于获得这种导电表面的电聚合单体以及将电聚合聚合物附着到导电表面的方法、设备和过程。本文介绍的聚合物、过程和设备可以有益地用于制备可植入医疗设备。
• Electropolymerizable Monomers and Polymeric Coatings on Implantable Devices Prepared Therefrom
  申请人：Domb Abraham J.

  公开号：US20090123514A1

  公开（公告）日：2009-05-14

  Conductive surfaces of e.g., implantable devices, coated with electropolymerized polymers having active substances attached thereto are disclosed. Electropolymerizable monomers designed and used for obtaining such conductive surfaces and processes, devices and methods for attaching the electropolymerized polymers to conductive surfaces are also disclosed. The polymers, processes and devices presented herein can be beneficially used in the preparation of implantable medical devices.

  揭示了涂有附着有活性物质的电聚合聚合物的导电表面，例如可植入设备。还揭示了设计和用于获得这种导电表面的电聚合单体以及将电聚合聚合物附着到导电表面的方法、装置和方法。在制备可植入医疗器械方面，本文介绍的聚合物、过程和装置可以有益地使用。
• Modified conductive surfaces having active substances attached thereto
  申请人：Domb Abraham J.

  公开号：US20090232867A1

  公开（公告）日：2009-09-17

  Novel processes for coating metal surfaces and/or for attaching active substances to metal surfaces, objects having coated metal surfaces and/or active substances attached thereto and uses thereof in the preparation of implantable devices are disclosed.

  本发明揭示了用于涂覆金属表面和/或将活性物质附着于金属表面的新型工艺，具有涂覆金属表面和/或附着活性物质的物体以及在制备可植入设备中的使用。
• 一种壳聚糖衍生物分子印迹功能单体、其制备方法及应用
  申请人：扬州工业职业技术学院

  公开号：CN114133418B

  公开（公告）日：2023-07-28

  本案涉及一种壳聚糖衍生物分子印迹功能单体、其制备方法和应用，该功能单体分子结构式如下：记为PPACO，其中n＝3～10；分别称取利巴韦林、PPACO溶于0.25M的醋酸缓冲液中，加入吡咯，置于10mL电解池中，采用三电极体系，在0V至0.8V范围CV扫描，扫描圈数为5，扫描速率为20mVs‑1，得分子印迹膜修饰电极，将此修饰电极洗脱，得到利巴韦林分子印迹电化学传感器。本案的制备方法既可以向壳寡糖分子中同时引入可聚合的吡咯基团和柔性的氨基酸侧链基团，又不会因为吡咯基而大幅降低壳寡糖的水溶性；反应条件温和，收率高，反应可定量；反应完成后，无需透析，可节约大量时间，使得合成更快捷。