1-(3,4-dihexadecoxyphenyl)-N,N-dimethylmethanamine | 917079-06-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3,4-dihexadecoxyphenyl)-N,N-dimethylmethanamine
• CAS: 917079-06-2
• 化学式: C₄₁H₇₇NO₂
• 分子量: 616.068
• InChiKey: YYPGGTJRYXDLFI-UHFFFAOYSA-N

物化性质

• 沸点：
  650.3±40.0 °C(Predicted)
• 密度：
  0.893±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  17.2
• 重原子数：
  44
• 可旋转键数：
  34
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(3,4-dihexadecoxyphenyl)-N,N-dimethylmethanamine 、 间二溴苄 以 甲醇 、 乙酸乙酯 为溶剂， 反应 24.0h， 以60%的产率得到
  参考文献：
  名称：

  Synthesis of novel dimeric cationic lipids based on an aromatic backbone between the hydrocarbon chains and headgroup

  摘要：

  Seven dimeric cationic lipids possessing an aromatic anchor between the hydrocarbon chains and cationic headgroup have been synthesized. The spacers in these lipids vary in length, hydrophobicity and flexibility. The synthesis, membrane-forming properties and complexation with plasmid DNA (lipoplex formation) are briefly described. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.09.072
• 作为产物：
  描述：

  原儿茶酸 在 盐酸 、 lithium aluminium tetrahydride 、 三溴化磷 、 potassium carbonate 作用下， 以 四氢呋喃 、 二氯甲烷 、 丙酮 为溶剂， 反应 144.0h， 生成 1-(3,4-dihexadecoxyphenyl)-N,N-dimethylmethanamine
  参考文献：
  名称：

  Synthesis of novel dimeric cationic lipids based on an aromatic backbone between the hydrocarbon chains and headgroup

  摘要：

  Seven dimeric cationic lipids possessing an aromatic anchor between the hydrocarbon chains and cationic headgroup have been synthesized. The spacers in these lipids vary in length, hydrophobicity and flexibility. The synthesis, membrane-forming properties and complexation with plasmid DNA (lipoplex formation) are briefly described. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.09.072

文献信息

• Synthesis of novel dimeric cationic lipids based on an aromatic backbone between the hydrocarbon chains and headgroup
  作者：Bishwajit Paul、Avinash Bajaj、S.S. Indi、Santanu Bhattacharya

  DOI：10.1016/j.tetlet.2006.09.072

  日期：2006.11

  Seven dimeric cationic lipids possessing an aromatic anchor between the hydrocarbon chains and cationic headgroup have been synthesized. The spacers in these lipids vary in length, hydrophobicity and flexibility. The synthesis, membrane-forming properties and complexation with plasmid DNA (lipoplex formation) are briefly described. (c) 2006 Elsevier Ltd. All rights reserved.