N-ethyl-2,6-diisopropylaniline | 92069-46-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-ethyl-2,6-diisopropylaniline
• 英文别名: N-ethyl-2,6-di(propan-2-yl)aniline
• CAS: 92069-46-0
• 化学式: C₁₄H₂₃N
• 分子量: 205.343
• InChiKey: AOZBANWETYZEPL-UHFFFAOYSA-N

物化性质

• 沸点：
  100-103 °C(Press: 1-2 Torr)
• 密度：
  0.910±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-ethyl-2,6-diisopropylaniline 在 potassium carbonate 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 生成
  参考文献：
  名称：

  ACAT inhibitors derived from hetero-Diels-Alder cycloadducts of thioaldehydes

  摘要：

  Acyl-CoA:cholesterol acyltransferase (ACAT) is the enzyme largely responsible for intracellular cholesterol esterification. A systemic inhibitor of ACAT is believed to be able to slow or even reverse the atherosclerotic process. Towards that goal, a series of cyclic sulfides, derived from the hetero-Diels-Alder reaction of thioaldehydes with 1,3-dienes, and bearing carboxamide substituents, were prepared and evaluated for in vitro (in several tissues and species) and ex vivo ACAT inhibition. Minor changes in subsequent structure were found to have a significant effect in optimization of the biological activity of this series of compounds. Copyright (C) 1996 The DuPont Merck Pharmaceutical Company.

  DOI：

  10.1016/0968-0896(96)00143-5
• 作为产物：
  描述：

  N-(2,6-diisopropylphenyl)acetamide 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 10.0h， 以64%的产率得到N-ethyl-2,6-diisopropylaniline
  参考文献：
  名称：

  ACAT inhibitors derived from hetero-Diels-Alder cycloadducts of thioaldehydes

  摘要：

  Acyl-CoA:cholesterol acyltransferase (ACAT) is the enzyme largely responsible for intracellular cholesterol esterification. A systemic inhibitor of ACAT is believed to be able to slow or even reverse the atherosclerotic process. Towards that goal, a series of cyclic sulfides, derived from the hetero-Diels-Alder reaction of thioaldehydes with 1,3-dienes, and bearing carboxamide substituents, were prepared and evaluated for in vitro (in several tissues and species) and ex vivo ACAT inhibition. Minor changes in subsequent structure were found to have a significant effect in optimization of the biological activity of this series of compounds. Copyright (C) 1996 The DuPont Merck Pharmaceutical Company.

  DOI：

  10.1016/0968-0896(96)00143-5

文献信息

• Diethylzinc/CuII-mediated alkylation of aromatic amines and related compounds
  作者：Cédric Brielles、Jerry J Harnett、Eric Doris

  DOI：10.1016/s0040-4039(01)01775-0

  日期：2001.11

  A mild and efficient method for the N-alkylation of aromatic amines and related compounds is described. The approach developed herein utilizes, as the key step, a transmetallation between a cupric salt and the dialkylzinc species.

  描述了一种温和且有效的芳族胺和相关化合物的N-烷基化方法。本文开发的方法利用铜盐和二烷基锌物质之间的金属转移作为关键步骤。
• Alkylation of aromatic amines and related compounds using a copper(II)-aluminum(III) couple
  作者：Derek H.R. Barton、Eric Doris

  DOI：10.1016/0040-4039(96)00579-5

  日期：1996.5

  Copper(II)-mediated alkylation of amines and related compounds (e.g. hydrazines, hydrazones, hydroxylamines) using an alkyl aluminum reagent is described. The reaction proceeds selectively and in good yield, utililizing a metal-metal exchange as the key step.

  描述了使用烷基铝试剂的铜（II）介导的胺和相关化合物（例如肼，，羟胺）的烷基化。利用金属-金属交换作为关键步骤，反应以高收率选择性地进行。
• Arylaminosilane Compound, Propylene Polymerization Catalyst And Preparation Thereof
  申请人：PetroChina Company Limited

  公开号：US20200369689A1

  公开（公告）日：2020-11-26

  The present disclosure discloses an arylaminosilane compound, a propylene polymerization catalyst and preparation thereof. The arylaminosilane compound has a structure of wherein R 1 is a C 1 -C 8 alkyl group or a C 1 -C 8 silanyl group; R 2 , R 3 , R 4 , R 5 and R 6 are each independently H or a C 1 -C 12 alkyl group; R 7 , R 8 and R 9 are each independently a C 1 -C 8 alkyl group or a C 1 -C 8 alkoxy group. When the arylaminosilane compound is used as an external electron donor of a propylene polymerization catalyst in propylene polymerization reaction, the catalyst has good hydrogen response.

  本公开揭示了一种芳基氨基硅烷化合物、丙烯聚合催化剂及其制备方法。该芳基氨基硅烷化合物的结构为其中R1是C1-C8烷基或C1-C8硅烷基；R2、R3、R4、R5和R6分别独立地为H或C1-C12烷基；R7、R8和R9分别独立地为C1-C8烷基或C1-C8烷氧基。当该芳基氨基硅烷化合物作为丙烯聚合催化剂的外部电子受体在丙烯聚合反应中使用时，催化剂具有良好的氢响应。
• Verfahren zur Herstellung von N-alkylsubstituierten Cyclohexylaminen
  申请人：BASF Aktiengesellschaft

  公开号：EP0108323A1

  公开（公告）日：1984-05-16

  Verfahren zur Herstellung von cycloaliphatischen Aminen durch Hydrierung von aromatischen Aminen in Gegenwart eines Hydrierkatalysators, wobei man einen Trägerkatalysator verwendet, der als Träger Aluminiumoxid oder eine Aluminiumoxid enthaltende Verbindung, Palladium und eine basische Verbindung und/oder ein Element der Gruppe Ib, IIb, Vllb, Eisen, Kobalt oder Nickel enthält, dadurch gekennzeichnet, daß man als aromatische Amine N-Alkyl- bzw. N-Arylaniline einsetzt.

  一种在氢化催化剂存在下通过芳香胺氢化制备环脂族胺的工艺，其中使用一种含有氧化铝或含氧化铝的化合物、钯和碱性化合物和/或 Ib、IIb、Vllb 族元素、铁、钴或镍的支撑催化剂作为支撑催化剂，其特征在于使用 N-烷基或 N-芳基苯胺作为芳香胺。
• Arylaminosilane compound, propylene polymerization catalyst and preparation thereof
  申请人：PetroChina Company Limited

  公开号：US11535638B2

  公开（公告）日：2022-12-27

  The present disclosure discloses an arylaminosilane compound, a propylene polymerization catalyst and preparation thereof. The arylaminosilane compound has a structure of wherein R 1 is a C 1 -C 8 alkyl group or a C 1 -C 8 silanyl group; R 2 , R 3 , R 4 , R 5 and R 6 are each independently H or a C 1 -C 12 alkyl group; R 7 , R 8 and R 9 are each independently a C 1 -C 8 alkyl group or a C 1 -C 8 alkoxy group. When the arylaminosilane compound is used as an external electron donor of a propylene polymerization catalyst in propylene polymerization reaction, the catalyst has good hydrogen response.

  本发明公开了一种芳基氨基硅烷化合物、丙烯聚合催化剂及其制备方法。该芳基氨基硅烷化合物的结构为 其中 R 1 是 C 1 -C 8 烷基或 C 1 -C 8 硅烷基； R 2 , R 3 , R 4 , R 5 和 R 6 各自独立地为 H 或 C 1 -C 12 烷基；R 7 , R 8 和 R 9 各自独立地为 C 1 -C 8 烷基或 C 1 -C 8 烷氧基。在丙烯聚合反应中，当芳基氨基硅烷化合物用作丙烯聚合催化剂的外部电子供体时，催化剂具有良好的氢响应。