(E)-1-phenyl-Npropylidenemethanamine | 88304-24-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-1-phenyl-Npropylidenemethanamine
• 英文别名: benzyl-prop-(E)-ylidene-amine
• CAS: 88304-24-9
• 化学式: C₁₀H₁₃N
• 分子量: 147.22
• InChiKey: JEJVKKAYKKSTRU-DHZHZOJOSA-N

物化性质

• 沸点：
  235.4±23.0 °C(Predicted)
• 密度：
  0.87±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.67
• 重原子数：
  11.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  12.36
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  (E)-1-phenyl-Npropylidenemethanamine 在 2,6-二甲基吡啶 、 palladium 10% on activated carbon 、 氢气 、 三乙胺 作用下， 以 乙醇 、 二氯甲烷 、 乙酸乙酯 为溶剂， 30.0 ℃ 、9.0 MPa 条件下， 反应 0.03h， 生成 (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl-2-benzyl-4-methyl-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate
  参考文献：
  名称：

  Spirocyclic Dihydropyridines by Electrophile-Induced Dearomatizing Cyclization of N-Alkenyl Pyridinecarboxamides

  摘要：

  On treatment with acylating or sulfonylating agents, N-alkenyl pyridine carboxamides (N-pyridinecarbonyl enamines) undergo a dearomatizing cyclization initiated by pyridine acylation and followed by intramolecular trapping of the resulting pyridinium cation. The products are spirocyclic dihydropyridines which may be further elaborated to spirocyclic heterocycles with drug-like features.

  DOI：

  10.1021/ol400571j
• 作为产物：
  描述：

  丙醛 、 苄胺 以 二氯甲烷 为溶剂， 生成 (E)-1-phenyl-Npropylidenemethanamine
  参考文献：
  名称：

  Spirocyclic Dihydropyridines by Electrophile-Induced Dearomatizing Cyclization of N-Alkenyl Pyridinecarboxamides

  摘要：

  On treatment with acylating or sulfonylating agents, N-alkenyl pyridine carboxamides (N-pyridinecarbonyl enamines) undergo a dearomatizing cyclization initiated by pyridine acylation and followed by intramolecular trapping of the resulting pyridinium cation. The products are spirocyclic dihydropyridines which may be further elaborated to spirocyclic heterocycles with drug-like features.

  DOI：

  10.1021/ol400571j

文献信息

• Unprecedented asymmetric induction from a chiral acetate enolate equivalent. The condensation of acetyl(triphenylphosphine)carbonyl-.eta.-cyclopentadienyliron [(.eta.-C5H5)Fe(CO)(PPh3)(Ac)] with imines
  作者：Lanny S. Liebeskind、Mark E. Welker、Virgil Goedken

  DOI：10.1021/ja00314a042

  日期：1984.1

  Diverses imines se condensent avec le diethyl-Al-enolate du racemique (η-C 5 H 5 )Fe(CO)(PPh 3 )COCH 3 en donnant des produits de condensation avec un bon rendement

  Diverses 亚胺 se condensent avec le diethyl-Al-enolate du racemique (η-C 5 H 5 )Fe(CO)(PPh 3 )COCH 3 en donnant des produits de condensent avec un bon rendement
• The threo-selective reaction of allenic organometallic compounds with imines
  作者：Yoshinori Yamamoto、Wataru Ito、Kazuhiro Maruyama

  DOI：10.1039/c39840001004

  日期：——

  The reaction between the imines (2) and the allenic organometallic compounds (3) gives the threo adducts (4) with very high stereoselectivity, while the reaction with 9-but-2-enyl-9-borabicyclo[3.3.1]nonane gives the analogous erythro allylamines stereoselectively.

  亚胺（2）和烯丙基有机金属化合物（3）之间的反应可生成苏式加合物（4），具有很高的立体选择性，而与9-丁-2-烯基-9-硼环[3.3.1]壬烷的反应可得到类似的赤型烯丙基胺立体选择性地。
• Synthesis of substituted pyrroles from an alkyne, an imine and carbon monoxide via an organotitanium intermediate
  作者：Yuan Gao、Masaaki Shirai、Fumie Sato

  DOI：10.1016/0040-4039(96)01778-9

  日期：1996.10

  Azatitanacyclopentene complexes 2 react with carbon monoxide under atmospheric pressure to afford pyrroles in good to excellent yields, thus providing a convenient and general method for synthesis of substituted pyrroles from an alkyne, an imine and carbon monoxide.

  氮杂环丁烷环戊烯配合物2在大气压下与一氧化碳反应，以良好至优异的产率提供吡咯，因此提供了从炔烃，亚胺和一氧化碳合成取代的吡咯的方便且通用的方法。
• <i>In Situ</i> Generation of Titanium-imine Complexes from Imines and Ti(O<i>i</i>Pr)₄/2 <i>i</i>PrMgX, and Their Reactions with Alkynes, Nitriles and Imines
  作者：Yuan Gao、Yukio Yoshida、Fumie Sato

  DOI：10.1055/s-1997-1555

  日期：——

  Reaction of (η2-propene)Ti(OiPr)2 (1), readily generated in situ by the reaction of Ti(OiPr)4 with 2 equiv of iPrMgCl, with imines affords the titanium-imine complexes in moderate to excellent yields, which undergo coupling reactions with alkynes, nitriles and imines.

  (δ-2-propene)Ti(OiPr)2 (1) 很容易通过 Ti(OiPr)4 与 2 个等量的 iPrMgCl 反应就地生成，与亚胺反应生成的钛-亚胺配合物产量中等到极好，可与炔类、腈类和亚胺发生偶联反应。
• HETEROARYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS
  申请人：Hutchinson John Howard

  公开号：US20110319445A1

  公开（公告）日：2011-12-29

  Described herein are heteroaryl compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the heteroaryl compounds described. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.

  本文描述了异杂环化合物，它们是PGD2受体的拮抗剂。还描述了包括所述异杂环化合物的制药组合物和药物。本文还描述了使用这种PGD2受体拮抗剂的方法，单独或与其他化合物结合，用于治疗呼吸系统、心血管系统和其他PGD2依赖或PGD2介导的疾病或病症。