3-cyanomethyl-indole-N-acetic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-cyanomethyl-indole-N-acetic acid
• 英文别名: 2-[3-(Cyanomethyl)indol-1-yl]acetic acid
• 化学式: C₁₂H₁₀N₂O₂
• 分子量: 214.224
• InChiKey: ZXLGCODLRRPKAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  吲哚-3-乙腈 、 溴乙酸乙酯 以 乙酸乙酯 、 乙腈 为溶剂， 以49%的产率得到3-cyanomethyl-indole-N-acetic acid
  参考文献：
  名称：

  Substituted indolealkanoic acids

  摘要：

  揭示了替代吲哚烷基酸，可用于治疗糖尿病引起的慢性并发症。还揭示了含有这些化合物的药物组合物，以及使用这些化合物的治疗方法，以及它们的合成方法。

  公开号：

  US06214991B1

文献信息

• Methods for reducing uric acid levels
  申请人：——

  公开号：US20010044437A1

  公开（公告）日：2001-11-22

  Disclosed are methods of reducing serum uric acid levels, the methods comprising administration of substituted indolealkanoic acids to patients in need of such treatment. Also disclosed are such compounds useful in the treatment of gout and related diseases. Also disclosed are pharmaceutical compositions containing the compounds.

  揭示了降低血清尿酸水平的方法，该方法包括向需要此类治疗的患者施用取代的吲哚烷基酸。还揭示了这些化合物在痛风和相关疾病治疗中的用途。还揭示了含有这些化合物的药物组合物。
• Compositions containing a substituted indolealkanoic acid and an angiotensin converting enzyme inhibitor
  申请人：——

  公开号：US20010041722A1

  公开（公告）日：2001-11-15

  Disclosed are methods of reducing serum glucose and triglyceride levels and for inhibiting angiogenesis, the methods comprising administration of substituted indolealkanoic acids to patients in need of such treatment. Also disclosed are such compounds useful in the treatment of angiogenesis, hyperglycemia, hyperlipidemia and chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds. Further, disclosed are combinations of an angiotensin converting enzyme inhibitor and a substituted indole acetic acid.

  本发明公开了一种降低血清葡萄糖和甘油三酯水平以及抑制血管生成的方法，包括给需要这种治疗的患者使用取代吲哚烷基酸。还公开了这种化合物在治疗血管生成、高血糖、高血脂以及糖尿病所引起的慢性并发症方面的用途。还公开了含有这些化合物的药物组合物。此外，还公开了血管紧张素转换酶抑制剂和取代吲哚乙酸的组合物。
• Methods of reducing serum glucose and triglyceride levels and for inhibiting angiogenesis using substituted indolealkanoic acids
  申请人：Institute for Pharmaceutical Discovery, L.L.C.

  公开号：US06555568B1

  公开（公告）日：2003-04-29

  Disclosed are methods of reducing serum glucose and triglyceride levels and for inhibiting angiogenesis, the methods comprising administration of substituted indolealkanoic acids to patients in need of such treatment. Also disclosed are such compounds useful in the treatment of angiogenesis, hyperglycemia, hyperlipidemia and chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds.

  揭示了一种降低血清葡萄糖和甘油三酯水平以及抑制血管生成的方法，该方法包括向需要该治疗的患者施用取代的吲哚烷基酸。还揭示了这些化合物在治疗血管生成、高血糖、高血脂和糖尿病引起的慢性并发症方面的用途。还揭示了含有这些化合物的药物组合物。
• Substituted indolealkanoic acids derivative and formulations containing same for use in the treatment of diabetic complications
  申请人：Van Zandt C. Michael

  公开号：US20060100255A1

  公开（公告）日：2006-05-11

  Disclosed is a compound of the formula (I) its hydrates and/or pharmaceutically acceptable salts, which are useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their preparation.

  本发明涉及一种公式（I）的化合物及其水合物和/或药学上可接受的盐，其在治疗由糖尿病引起的慢性并发症方面具有有用的作用。本发明还涉及含有该化合物的药物组合物和使用该化合物的治疗方法，以及制备该化合物的方法。
• Method of reducing serum glucose and triglyceride levels and for inhibiting angiogenesis using substitute indolealkanoic acids
  申请人：The Institute for Pharmaceutical Discovery, Inc.

  公开号：US20030216452A1

  公开（公告）日：2003-11-20

  Disclosed are methods of reducing serum glucose and triglyceride levels and for inhibiting angiogenesis, the methods comprising administration of substituted indolealkanoic acids to patients in need of such treatment. Also disclosed are such compounds useful in the treatment of angiogenesis, hyperglycemia, hyperlipidemia and chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds.

  本发明揭示了一种减少血清葡萄糖和甘油三酯水平、抑制血管生成的方法，该方法包括向需要此类治疗的患者给予取代的吲哚烷基酸。还揭示了这些化合物在治疗血管生成、高血糖、高脂血症和糖尿病慢性并发症方面的用途。还揭示了包含这些化合物的制药组合物。