epoxy-2,3 propyl cyclopentane | 104727-79-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环氧化物
• 英文名称: epoxy-2,3 propyl cyclopentane
• 英文别名: 2-(Cyclopentylmethyl)oxirane
• CAS: 104727-79-9
• 化学式: C₈H₁₄O
• mdl: MFCD22414016
• 分子量: 126.199
• InChiKey: PSBATMRQJOXMIS-UHFFFAOYSA-N

物化性质

• 沸点：
  75-77 °C(Press: 25 Torr)
• 密度：
  0.996±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  epoxy-2,3 propyl cyclopentane 在 硫脲 作用下， 以 甲醇 为溶剂， 反应 18.0h， 以53%的产率得到2-(cyclopentylmethyl)thiirane
  参考文献：
  名称：

  烯烃有机催化合成硫杂丙烷

  摘要：

  已经开发出一种温和、可持续和高效的有机催化合成硫杂丙环的烯烃。从烯烃开始，利用 Kokotos 小组开发的环氧化方案，该方案使用 2,2,2-三氟苯乙酮作为有机催化剂，H 2 O 2作为氧化剂，然后用硫脲开环，合成了多种硫杂环丙烷中等至极好的产量。

  DOI：

  10.1002/ejoc.202200463
• 作为产物：
  描述：

  烯丙基环戊烷 在 2,2,2-三氟苯乙酮 、 双氧水 、 乙腈 作用下， 以 叔丁醇 为溶剂， 生成 epoxy-2,3 propyl cyclopentane
  参考文献：
  名称：

  烯烃有机催化合成硫杂丙烷

  摘要：

  已经开发出一种温和、可持续和高效的有机催化合成硫杂丙环的烯烃。从烯烃开始，利用 Kokotos 小组开发的环氧化方案，该方案使用 2,2,2-三氟苯乙酮作为有机催化剂，H 2 O 2作为氧化剂，然后用硫脲开环，合成了多种硫杂环丙烷中等至极好的产量。

  DOI：

  10.1002/ejoc.202200463

文献信息

• Process for producing 1,3-dialkyl-2-imidazolidinone compound
  申请人：——

  公开号：US20030009035A1

  公开（公告）日：2003-01-09

  There is provided a process for preparing a 1,3-dialkyl-2-imidazolidinone by using an alkylene oxide as a first component, using at least one of (A) carbon dioxide and a monoalkylamine; (B) a carbon dioxide compound of the monoalkylamine; and (C) an 1,3-dialkylurea, reacting the first and second components by heating at 50 ° C. or higher to give 1,3-dialkyl-2-imidazolidinone, characterized in that the total molar amount of a molar feed amount of the monoalkylamine included in the component (A), a molar feed amount of the monoalkylamine part of the carbon dioxide compound of monoalkylamine, component (B), and the double of a molar feed amount of the 1,3-dialkylurea, component (C), is at least three folds of a molar feed amount of the alkylene oxide. The preparation process of this invention uses an industrially readily available alkylene oxide as a starting material and can be suitably conducted with a higher yield in an industrial scale.

  提供了一种制备1,3-二烷基-2-咪唑烷酮的方法，该方法使用乙烯氧化物作为第一组分，至少使用以下之一：（A）二氧化碳和一种单烷基胺；（B）单烷基胺的二氧化碳化合物；和（C）1,3-二烷基脲，通过加热至50°C或更高温度来使第一和第二组分反应，得到1,3-二烷基-2-咪唑烷酮，其特点是：单烷基胺的摩尔进料量包括在组分（A）中的单烷基胺的摩尔进料量，单烷基胺的二氧化碳化合物中的单烷基胺部分的摩尔进料量，组分（B），以及1,3-二烷基脲的摩尔进料量的两倍，组分（C），至少是乙烯氧化物的摩尔进料量的三倍。这种发明的制备过程使用工业上易得的乙烯氧化物作为起始物质，并且可以在工业规模上以更高的产率进行适当的操作。
• Deplacements homolytiques intramoleculaires
  作者：B. Maillard、E. Montaudon、F. Rakotomanana、M.J. Bourgeois

  DOI：10.1016/s0040-4020(01)96750-x

  日期：1985.1

  of allyl t-butyl peroxide in cyclohexane and tetrahydrofuran shows that an important induced decomposition of the peroxide occurs by the addition of radicals derived from the solvent, to the peroxide double bond, followed by an intramolecular homolytic displacement of the t-butoxyl group. Such a reaction is a 2,3-epoxypropanation of the solvent in which the initiator is decomposed. The reaction is

  烯丙基叔丁基过氧化物在环己烷和四氢呋喃中热解的产物分析表明，过氧化物的重要诱导分解是通过将源自溶剂的自由基添加到过氧化物双键中，然后将t的分子内均质置换而完成的。 -丁氧基。该反应是引发剂分解的溶剂的2，3-环氧丙烷化。通过使用其他醚和环烷烃作为溶剂，表明该反应是一般的。
• PROCESS FOR PRODUCING 1,3-DIALKYL-2-IMIDAZOLIDINONE COMPOUND
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1279667A1

  公开（公告）日：2003-01-29

  There is provided a process for preparing a 1,3-dialkyl-2-imidazolidinone by using an alkylene oxide as a first component, using at least one of (A) carbon dioxide and a monoalkylamine; (B) a carbon dioxide compound of the monoalkylamine; and (C) an 1,3-dialkylurea, reacting the first and second components by heating at 50 °C or higher to give 1, 3-dialkyl-2-imidazolidinone, characterized in that the total molar amount of a molar feed amount of the monoalkylamine included in the component (A) , a molar feed amount of the monoalkylamine part of the carbon dioxide compound of monoalkylamine, component (B), and the double of a molar feed amount of the 1, 3-dialkylurea, component (C), is at least three folds of a molar feed amount of the alkylene oxide. The preparation process of this invention uses an industrially readily available alkylene oxide as a starting material and can be suitably conducted with a higher yield in an industrial scale.

  本发明提供了一种制备 1，3-二烷基-2-咪唑烷酮的工艺，该工艺以环氧亚 烷为第一组分，使用 (A) 二氧化碳和单烷基胺；(B) 单烷基胺的二氧化碳化合物；和 (C) 1，3-二烷基脲中的至少一种；和 (C) 1，3-二烷基脲，通过在 50℃或更高温度下加热使第一和第二组分反应，得到 1，3-二烷基-2-咪唑烷酮，其特征在于，组分 (A) 中包含的单烷基胺的摩尔进料总量 、单烷基胺二氧化碳化合物的单烷基胺部分的摩尔进料量，组分(B)，以及 1，3-二烷基脲的摩尔进料量的双倍，组分(C)，至少是环氧亚烷基摩尔进料量的三倍。 本发明的制备工艺使用工业上容易获得的环氧亚烷烃作为起始原料，可以适当地在工业规模上以更高的产率进行。
• Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor
  作者：Michael P. DeNinno、Robert Schoenleber、Richard J. Perner、Linda Lijewski、Karen E. Asin、Donald R. Britton、Robert MacKenzie、John W. Kebabian

  DOI：10.1021/jm00112a034

  日期：1991.8

  The synthesis and dopaminergic activity of a series of C3 and nitrogen-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans (isochromans) is described. The synthesis of the compounds was stereospecific for the 1,3 cis isomer, and the enantioselective synthesis of both enantiomers of one of the analogoues (20) was achieved. It was determined that all of the dopaminergic activity resides in the [1R,3S] isomer. Generally, substitution at the C3 position provided compounds with very high potency (< 10 nm EC50) and selectivity for the D1 receptor, with a wide range of intrinsic activities (60-160%). Analogues containing C3 substituents including aryl, arylalkyl, and cyclic and acyclic alkyl groups showed a marked enhancement of dopaminergic activity compared to the unsubstituted compound. As a class, the drugs were orally active in the rat rotation model with a very long duration of action.
• MAILLARD, B.;MONTAUDON, E.;RAKOTOMANANA, F.;BOURGEOIS, M. J., TETRAHEDRON, 1985, 41, N 21, 5039-5043
  作者：MAILLARD, B.、MONTAUDON, E.、RAKOTOMANANA, F.、BOURGEOIS, M. J.

  DOI：——

  日期：——