丁基乙基二硫醚 | 63986-03-8

• 物质功能分类: 香精与香料 - 合成香料 - 硫醚类香料
• 分子结构分类: 有机化合物 - 有机硫化合物 - 有机二硫化物
• 中文名称: 丁基乙基二硫醚
• 英文名称: ethyl butyl disulfide
• 英文别名: butyl-ethyl-disulfane；ethyl-butyl disulfide；Aethyl-butyl-disulfid；ethyl n-butyl disulfide；Butyl ethyl disulfide；1-(ethyldisulfanyl)butane
• CAS: 63986-03-8
• 化学式: C₆H₁₄S₂
• mdl: MFCD02262175
• 分子量: 150.309
• InChiKey: QEYJAENSRLNDFW-UHFFFAOYSA-N

物化性质

• 熔点：
  -77.24°C (estimate)
• 沸点：
  196.2°C (estimate)
• 密度：
  0.9600
• LogP：
  3.90
• 物理描述：
  Clear, colourless or pale yellow liquid; Sulfureous aroma
• 溶解度：
  Soluble in non-polar solvents; insoluble in water
• 折光率：
  1.492-1.502
• 保留指数：
  1120;1120

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  8
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  50.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二丁基二硫 在 二甲基硫 、 一氧化二氮 作用下， 以 水 为溶剂， 生成 丁基乙基二硫醚
  参考文献：
  名称：

  有机硫化物的自由基阳离子氧化硫醇

  摘要：

  DOI：

  10.1021/j100264a030

文献信息

• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• [EN] POLYNUCLEOTIDE CONSTRUCTS HAVING DISULFIDE GROUPS<br/>[FR] CONSTRUCTIONS POLYNUCLÉOTIDIQUES CONTENANT DES GROUPES DISULFURE
  申请人：SOLSTICE BIOLOG LTD

  公开号：WO2015069932A1

  公开（公告）日：2015-05-14

  The invention features polynucleotide constructs containing one or more components (i) containing a disulfide linkage, where each of the one or more components is attached to an internudeotide bridging group or a terminal group of the polynucleotide construct, and each of the one or more components (i) contains one or more bulky groups proximal to the disulfide group. The invention also features polynucleotide constructs containing one or more components (i) containing a disulfide linkage, where each of the one or more components (i) is attached to an internudeotide bridging group or a terminal group of the polynucleotide construct, and each of the one or more components (i) contains at least 4 atoms in a chain between the disulfide linkage and the phosphorus atom of the internudeotide bridging group or the terminal group; and where the chain does not contain a phosphate, an amide, an ester, or an alkenylene. The invention also features methods of delivering a polynucleotide to a cell using the polynucleotide constructs of the invention.

  该发明涉及包含一个或多个组分（i）的聚核苷酸构造，其中每个一个或多个组分连接到聚核苷酸构造的一个核苷酸桥连基团或末端基团上，每个一个或多个组分（i）包含靠近二硫键的一个或多个臃肿基团。该发明还涉及包含一个或多个组分（i）的聚核苷酸构造，其中每个一个或多个组分（i）连接到聚核苷酸构造的一个核苷酸桥连基团或末端基团上，每个一个或多个组分（i）在二硫键和核苷酸桥连基团或末端基团的磷原子之间的链中至少包含4个原子；并且该链不包含磷酸酯、酰胺、酯或烯基烃。该发明还涉及使用该发明的聚核苷酸构造将聚核苷酸传递到细胞的方法。
• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：Senomyx, Inc.

  公开号：US20170096418A1

  公开（公告）日：2017-04-06

  The present disclosure relates to compounds which are useful as cooling sensation compounds.

  本公开涉及作为冷感化合物有用的化合物。
• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF CARDIOVASCULAR AND NEUROLOGICAL DISEASES<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT DE MALADIES CARDIOVASCULAIRES OU NEUROLOGIQUES
  申请人：KANDULA MAHESH

  公开号：WO2013168007A1

  公开（公告）日：2013-11-14

  The invention relates to the compounds of formula (I), formula (II) and formula (III) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula (I), formula (II) or formula (III) and methods for the treatment of cardiovascular and neurological diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment: of hyperglycemia, insulin resistance, diabetes mellitus, diabetes insipidus, type 1 diabetes, type 2 diabetes, microvascular complications, macrovascular complications, lipid disorders, prediabetes, obesity, arrhythmia, myocardial infarction, stroke, neuropathy, renal complications, hypertriglyceridemia, cardiovascular complications, postprandial hyperglycemia, depression, Alzheimer's disease, Parkinson's disease, Huntington's disease, inflammation, Crohn's disease, inflammatory bowel disease and obesity.

  本发明涉及公式(I)、公式(II)和公式(III)化合物或其药物可接受的盐，以及其多晶形、溶剂化物、对映体、立体异构体和水合物。含有公式(I)、公式(II)或公式(III)化合物的有效量的药物组合物，以及用于治疗心血管和神经系统疾病的方法可以制成口服、颊部、直肠、局部、经皮、经黏膜、静脉、肌肉注射、糖浆或注射剂。这样的组合物可以用于治疗：高血糖、胰岛素抵抗、糖尿病、尿崩症、1型糖尿病、2型糖尿病、微血管并发症、大血管并发症、脂质代谢异常、糖尿病前期、肥胖症、心律失常、心肌梗死、中风、神经病变、肾脏并发症、高甘油三酯血症、心血管并发症、餐后高血糖、抑郁症、阿尔茨海默病、帕金森病、亨廷顿病、炎症、克隆病、炎症性肠病和肥胖症。
• Crack healing and reclaiming of vulcanized rubber by triggering the rearrangement of inherent sulfur crosslinked networks
  作者：H. P. Xiang、H. J. Qian、Z. Y. Lu、M. Z. Rong、M. Q. Zhang

  DOI：10.1039/c5gc00754b

  日期：——

  Vulcanized rubber made from an industrial formula can be healed and reclaimed by activating the rearrangement of the inherent sulfur crosslinked networks under the catalysis of CuCl₂.

  使用工业配方制成的硫化橡胶可以在CuCl₂的催化下激活内在硫交联网络的重排，从而得以治愈和回收。

表征谱图