(2-乙氧基苯氧基)-乙酸 | 3251-30-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (2-乙氧基苯氧基)-乙酸
• 英文名称: (2-ethoxyphenoxy)-Acetic acid
• 英文别名: (2-ethoxy-phenoxy)-acetic acid；(2-Aethoxy-phenoxy)-essigsaeure；2-(2-ethoxyphenoxy)acetic acid
• CAS: 3251-30-7
• 化学式: C₁₀H₁₂O₄
• mdl: MFCD01124887
• 分子量: 196.203
• InChiKey: MZQTVOLNWAPPBT-UHFFFAOYSA-N

物化性质

• 熔点：
  70-71 °C
• 沸点：
  316.4±17.0 °C(Predicted)
• 密度：
  1.188±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2918990090
• 包装等级：
  III
• 危险类别：
  8
• 危险性防范说明：
  P261,P264,P270,P271,P280,P301+P312+P330,P302+P352,P304+P340+P312,P305+P351+P338+P310,P332+P313,P362,P403+P233,P405,P501
• 危险品运输编号：
  3261
• 危险性描述：
  H302,H315,H318,H335
• 储存条件：
  存放温度：2-8°C，干燥环境。

SDS

Material Safety Data Sheet

---

Section 1. Identification of the substance
Product Name: (2-Ethoxy-phenoxy)-acetic acid
Synonyms:

---

Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

---

Section 3. Composition/information on ingredients.
Ingredient name: (2-Ethoxy-phenoxy)-acetic acid
CAS number: 3251-30-7

---

Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

---

Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

---

Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

---

Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

---

Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

---

Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C10H12O4
Molecular weight: 196.2

---

Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide.

---

Section 11. Toxicological information
No data.

---

Section 12. Ecological information
No data.

---

Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

---

Section 14. Transportation information
Non-harzardous for air and ground transportation.

---

Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  氯化亚砜 、 (2-乙氧基苯氧基)-乙酸 反应 0.5h， 以to obtain (2-ethoxy-phenoxy)acetyl chloride的产率得到2-ethoxyphenoxyacetyl chloride
  参考文献：
  名称：

  Process for preparing sulfamoyl-substituted phenethylamine derivatives

  摘要：

  本发明涉及一种制备磺酰胺取代的苯乙胺衍生物的新工艺，具体地说，是一种公式为（1）的5-{2-[2-(2-烷氧基苯氧基)乙基氨基]丙基}-2-甲氧基苯磺酰胺的制备方法。

  公开号：

  US06914159B1
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium carbonate 作用下， 生成 (2-乙氧基苯氧基)-乙酸
  参考文献：
  名称：

  Johnson et al., Journal of the Chemical Society, 1953, p. 2136,2138

  摘要：

  DOI：

文献信息

• [EN] PROCESS FOR THE PREPARATION OF TAMSULOSIN<br/>[FR] PROCEDE DE PREPARATION DE TAMSULOSINE
  申请人：TORCAN CHEMICAL LTD

  公开号：WO2005051897A1

  公开（公告）日：2005-06-09

  There is provided a process for the preparation of tamsulosin of formula 5, involving a coupling reaction in the presence of an aluminum reagent between an ester of formula 2A and (R)-5-(2-amino)propyl-2-methoxy-benzenesulfonamide of formula 3 to yield tamsulosin amide, which is then reduced to yield tamsulosin.

  提供了一种制备化学式为5的坦索洛辛的方法，涉及在铝试剂存在下，在化学式2A的酯与化学式3的(R)-5-(2-氨基)丙基-2-甲氧基苯磺酰胺之间进行偶联反应，生成坦索洛辛酰胺，然后还原生成坦索洛辛。
• Nametkin et al., Zhurnal Analiticheskoi Khimii, 1950, vol. 5, p. 7,8
  作者：Nametkin et al.

  DOI：——

  日期：——
• Nametkin et al., Doklady Akademii Nauk SSSR, 1949, vol. 68, p. 77,79
  作者：Nametkin et al.

  DOI：——

  日期：——
• Pfeifer; Plonka; Dobbrodt, Pharmazie, 1990, vol. 45, # 10, p. 751 - 755
  作者：Pfeifer、Plonka、Dobbrodt、Franke、Steenbeck

  DOI：——

  日期：——
• PROCESS FOR PREPARING SULFAMOYL-SUBSTITUTED PHENETHYLAMINE DERIVATIVES
  申请人：Yonsung Fine Chemical Co. Ltd

  公开号：EP1363878A1

  公开（公告）日：2003-11-26