4-[3-(4-羟基苯基)戊烷-3-基]苯酚 | 3600-64-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-[3-(4-羟基苯基)戊烷-3-基]苯酚
• 英文名称: 3,3-bis(4-hydroxyphenyl)pentane
• 英文别名: 3,3-Bis-(4-hydroxy-phenyl)-pentan；4,4′-(pentane-3,3-diyl)diphenol；4-[3-(4-hydroxyphenyl)pentan-3-yl]phenol
• CAS: 3600-64-4
• 化学式: C₁₇H₂₀O₂
• 分子量: 256.345
• InChiKey: RKSBPFMNOJWYSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2907299090

反应信息

• 作为反应物：
  描述：

  4-[3-(4-羟基苯基)戊烷-3-基]苯酚 在 盐酸 作用下， 生成 4-(1-ethylpropyl)phenol
  参考文献：
  名称：

  Dianin, Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1891, vol. 23, p. 537

  摘要：

  DOI：
• 作为产物：
  描述：

  3-戊酮 、 苯酚 在 甲烷磺酸 作用下， 反应 120.0h， 以34%的产率得到4-[3-(4-羟基苯基)戊烷-3-基]苯酚
  参考文献：
  名称：

  新的二苯甲烷衍生物作为过氧化物酶体增殖物激活的受体α/γ双激动剂，具有抗增殖作用和线粒体活性

  摘要：

  我们筛选了一系列新的手性二苯基甲烷衍生物，并确定了强效双重PPARα/γ部分激动剂。由于活性最高的化合物1的两种对映异构体均表现出意想不到的相似的反式激活活性，因此我们进行了对接实验，以提供对其相似的部分激动作用的分子理解。我们还评估了对映体1和消旋体2抑制结直肠癌细胞增殖的能力：（S）-1表现出更强的活性，至少部分是由于Wnt /β-catenin信号通路的部分抑制在大多数结直肠癌中这种表达上调。最后，我们研究了（R）-1，（S）-1和（R，S）-2关于线粒体功能的研究，并证明它们通过上调肉碱/酰基肉碱载体（CAC）和肉碱-棕榈酰转移酶1（CPT1）基因来激活肉碱穿梭系统。与这些都是PPARα靶基因的观念相一致，我们测试并发现PPARα本身受一个正环调节。而且，这些化合物诱导了明显的线粒体生物发生。总之，我们确定了一系列新的PPARα/γ双重激动剂，这些激动剂具有与线粒体功能的强大活化和

  DOI：

  10.1016/j.ejmech.2016.12.047

文献信息

• Extended line emission around seven radio-loud quasars at redshift z ∼ 2
  作者：R. J. Wilman、R. M. Johnstone、C. S. Crawford

  DOI：10.1046/j.1365-8711.2000.03453.x

  日期：2000.9

  We present near-infrared spectra of seven radio-loud quasars with a median redshift of 2.1, five of which were previously known to have Lyα nebulae. Extended [O iii] λ5007 and Hα emission are evident around six objects, at the level of a few times 10−16 erg cm−2 arcsec−2 s−1 within ≃2 arcsec of the nucleus (≡16 kpc in the adopted cosmology). Nuclear [O ii] λ3727 is detected in three of the five quasars studied at this wavelength and clearly extended in one of them.The extended [O iii] tends to be brighter on the side of the nucleus with the stronger, jet-like radio emission, indicating at least that the extranuclear gas is distributed anisotropically. It is also typically redshifted by several hundred km s−1 from the nuclear [O iii], perhaps because of the latter being blueshifted from the host galaxy's systemic velocity. Alternatively, the velocity shifts could be due to infall (which is suggested by linewidths ∼1000 km s−1 FWHM) in combination with a suitable dust geometry. Lyα/Hα ratios well below the case B value suggest that some dust is present.Photoionization modelling of the [O iii]/[O ii] ratios in the extended gas suggests that its pressure is around or less than a few times 107 cm−3 K; any confining intracluster medium is thus likely to host a strong cooling flow. A comparison with lower redshift work suggests that there has been little evolution in the nuclear emission-line properties of radio-loud quasars between redshifts 1 and 2.

  我们展示了七个射电强类星体（具有2.1的中值红移）的近红外光谱，其中五个已知具有Lyα星云。六个天体周围显示出延展的[O iii] λ5007和Hα发射，位于核区≃2角秒（采用的宇宙学中的16千秒差距）内，亮度水平为每平方角秒每秒几乘以10^-16 尔格/平方厘米。在研究的五个类星体中，有三个在其波长上探测到了核区的[O ii] λ3727，其中一个明显延展。延展的[O iii]在具有较强类喷流射电发射的核区一侧更亮，表明至少非核区气体呈各向异性分布。它通常相对于核区[O iii]有数百公里每秒的红移，可能是由于后者相对于宿主星系的系统速度发生蓝移。或者，速度偏移可能是由于合并（由线宽≈1000公里每秒 FWHM 提示）结合适当的尘埃几何结构所致。远低于B值情况的Lyα/Hα比率表明存在一些尘埃。对延展气体中[O iii]/[O ii]比率的 photoionization 建模表明其压力约为或小于几乘以10^7 厘米^-3 K；因此，任何限制的星系团介质都可能伴随强烈的冷却流。与低红移工作的比较表明，在红移1到2之间，射电强类星体的核区发射线特性几乎没有演化。
• BISPHENOL COMPOSITION CONTAINING AROMATIC ALCOHOL SULFONATE AND METHOD FOR PRODUCING SAME, POLYCARBONATE RESIN AND METHOD FOR PRODUCING SAME, AND BISPHENOL PRODUCTION METHOD
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：US20200190004A1

  公开（公告）日：2020-06-18

  A bisphenol composition including a specific amount of aromatic alcohol sulfonate, and a simple method of producing it are provided. Also provided is a method of producing a polycarbonate resin in which, by using the bisphenol composition including a specific amount of aromatic alcohol sulfonate, melt polymerization reaction can be efficiently allowed to proceed to produce a polycarbonate resin having an excellent color tone. A bisphenol composition including an aromatic alcohol sulfonate at not less than 0.1 ppb by mass with respect to a bisphenol. A method of producing a bisphenol composition, including reacting a ketone or an aldehyde with an aromatic alcohol in the presence of sulfuric acid to produce a bisphenol composition. A method of producing a polycarbonate resin, including producing a polycarbonate resin using the bisphenol composition. A polycarbonate resin including a specific amount of aromatic alcohol sulfonate.

  提供了一种包括特定量芳香醇磺酸盐的双酚类组合物，以及生产该组合物的简单方法。还提供了一种生产聚碳酸酯树脂的方法，通过使用包括特定量芳香醇磺酸盐的双酚类组合物，可以有效地进行熔融聚合反应，生产具有优异色调的聚碳酸酯树脂。一种包括不少于双酚类的质量的0.1 ppb芳香醇磺酸盐的双酚类组合物。一种生产双酚类组合物的方法，包括在硫酸存在下将酮或醛与芳香醇反应以生产双酚类组合物。一种生产聚碳酸酯树脂的方法，包括使用双酚类组合物生产聚碳酸酯树脂。一种包括特定量芳香醇磺酸盐的聚碳酸酯树脂。
• Optically active compound and photosensitive resin composition
  申请人：——

  公开号：US20030211421A1

  公开（公告）日：2003-11-13

  A photoactive compound is used in combination with a photosensitizer, represented by the following formula (1): A −[( J ) m −( X-Pro )] n (1) wherein A represents a hydrophobic unit comprising at least one kind of hydrophobic groups selected from a hydrocarbon group and a heterocyclic group, J represents a connecting group, X-Pro represents a hydrophilic group protected by a protective group Pro which is removable by light exposure, m represents 0 or 1, and n represents an integer of not less than 1. The protective group Pro may be removable by light exposure in association with the photosensitizer (especially, a photo acid generator), or may be a hydrophobic protective group. The hydrophilic group may be a hydroxyl group or a carboxyl group. The photoactive compound has high sensitivity to a light source of short wavelength beams, for resist application, therefore, the photoactive compound is advantageously used for forming a pattern with high resolution.

  一种光活性化合物与光敏剂结合使用，由以下公式（1）表示： A −[( J ) m −( X-Pro )] n (1) 其中，A代表至少包括一种从烃基和杂环基中选择的疏水基的疏水单元，J代表连接基团，X-Pro代表由光照可去除的保护基团Pro保护的亲水基团，m代表0或1，n代表不少于1的整数。 保护基团Pro可以与光敏剂（特别是光酸发生剂）一起通过光照可去除，也可以是疏水保护基团。亲水基团可以是羟基或羧基。光活性化合物对短波长光源具有很高的敏感性，用于光刻应用，因此，该光活性化合物有利于形成具有高分辨率的图案。
• Organic Silicon-Based Compound And Method Of Producing The Same
  申请人：Kikuchi Taketoshi

  公开号：US20070203275A1

  公开（公告）日：2007-08-30

  Provided are an organic silicon compound of the following formula (I): (wherein, R 1 to R 20 represent each independently alkyl, alkoxy, aryloxy, cycloalkyl, alkylcycloalkyl, aryl, dialkylamino or the like, and the aryloxy and aryl may be substituted with a substituent selected from the group consisting of alkyl, alkoxy and alkoxyalkyl.) which can be used for suppression of coloration and thermal deterioration of an organic material in molding, and an organic material composition containing the organic silicon compound and a method of producing the organic silicon compound.

  提供以下式(I)的有机硅化合物：（其中，R1到R20分别独立表示烷基、烷氧基、芳氧基、环烷基、烷基环烷基、芳基、二烷基氨基或类似物，芳氧基和芳基可被从烷基、烷氧基和烷氧基中选择的取代基所取代。）该化合物可用于抑制有机材料在成型过程中的着色和热降解，以及含有该有机硅化合物的有机材料组合物和生产该有机硅化合物的方法。
• Artificial pulp particles, process for producing same and paper-like sheet prepared therefrom
  申请人：TEIJIN LIMITED

  公开号：EP0027516A1

  公开（公告）日：1981-04-29

  Artificial pulp particles useful for producing paper-like sheet having excellent insulating property, heat resistance and reduced moisture-absorbing property, are composed of a plurality of fine particulate core consistuents consisting of a polyester material, for example, polyethylene terephthalate or polyethylene 2,6-napthalate, which are embedded whithin and connected to each other by a matrix constituent consisting of a heat-resistant aromatic polymer material, for example, poly-m-phenylene isophthalamide, which is soluble in a solvent not capable of dissolving therein the polyester material.

  人工纤维素颗粒用于生产具有优异绝缘性能、耐热性和减少吸湿性能的类纸张片，由多种细颗粒核心成分组成，包括聚酯材料，例如聚对苯二甲酸乙二酯或聚对苯二甲酸2,6-萘酯，这些核心成分被嵌入并通过热稳定芳香聚合物材料组成的基体成分连接在一起，例如可溶于溶剂但不能溶解聚酯材料的聚间苯二甲酰胺。