(2-pyrimidyl)(2-thiazolyl)amine | 58061-60-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (2-pyrimidyl)(2-thiazolyl)amine
• 英文别名: 2-(2'-pyrimidylamino)thiazole；pyrimidin-2-yl-thiazol-2-yl-amine；Pyrimidin-2-yl-thiazol-2-yl-amin；2-Pyrimidyl-(2)-aminothiazol；Thiazolylaminopyrimidine；N-pyrimidin-2-yl-1,3-thiazol-2-amine
• CAS: 58061-60-2
• 化学式: C₇H₆N₄S
• 分子量: 178.217
• InChiKey: AZBNUSYSAPQHQI-UHFFFAOYSA-N

物化性质

• 熔点：
  213-214 °C(Solv: N,N-dimethylformamide (68-12-2))
• 沸点：
  370.0±25.0 °C(Predicted)
• 密度：
  1.429±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2-pyrimidyl)(2-thiazolyl)amine 在 溴 、 sodium methylate 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 生成 3-[2-(Pyrimidin-2-ylamino)-thiazol-5-ylsulfanyl]-benzoic acid
  参考文献：
  名称：

  Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors

  摘要：

  A series of structurally novel aminothiazole based small molecule inhibitors of Itk were prepared to elucidate their structure-activity relationships (SARs), selectivity, and cell activity in inhibiting IL-2 secretion in a Jurkat T-cell assay. Compound 3 is identified as a potent and selective Itk inhibitor which inhibits anti-TCR antibody induced IL-2 production in mice in vivo and was previously reported to reduce lung inflammation in a mouse model of ovalbumin induced allergy/asthma. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.04.060
• 作为产物：
  描述：

  N-(pyrimidin-2-ylcarbamothioyl)benzamide 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 2.08h， 生成 (2-pyrimidyl)(2-thiazolyl)amine
  参考文献：
  名称：

  Kaplan, G. M.; Frolov, A. N.; El'tsov, A. V., Journal of Organic Chemistry USSR (English Translation), 1991, vol. 27, # 1.2, p. 177 - 182

  摘要：

  DOI：

文献信息

• AMINOTHIAZOLE DERIVATIVES AS INHIBITORS OF MARK
  申请人：Bettati Michela

  公开号：US20100009987A1

  公开（公告）日：2010-01-14

  Compounds of formula (I): inhibit microtubule affinity regulating kinase (MARK) and therefore find use in treatment of neurodegenerative diseases associated with hyperphosphorylation of tau.

  化学式为（I）的化合物：抑制微管亲和力调节激酶（MARK），因此可用于治疗与tau过度磷酸化相关的神经退行性疾病。
• Treatment of neurological disorders
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US10188650B2

  公开（公告）日：2019-01-29

  Provided herein is technology relating to treatment of neurological disorders and particularly, but not exclusively, to methods and compositions for treating neurological disorders caused by aberrant and/or dysregulated expression and/or activity of Down syndrome cell adhesion molecule (Dscam) with agents that modulate physiological components associated with the functions and/or dysfunctions of Dscam, e.g., physiological components that can be modulated to counteract aberrant Dscam expression and/or activity such as Abelson murine leukemia viral oncogene homolog 1 kinase.

  本文提供的技术涉及神经系统疾病的治疗，特别是（但不限于）用调节与Dscam的功能和/或功能障碍相关的生理成分的制剂治疗由唐氏综合征细胞粘附分子（Dscam）的异常和/或失调表达和/或活性引起的神经系统疾病的方法和组合物，例如，可被调节以抵消异常Dscam表达和/或活性的生理成分，如Abelson鼠白血病病毒癌基因同源物1激酶。
• Pd-Catalyzed <i>N</i>-Arylation of Heteroarylamines
  作者：Jingjun Yin、Matthew M. Zhao、Mark A. Huffman、James M. McNamara

  DOI：10.1021/ol0265923

  日期：2002.10.1

  [GRAPHICS]The palladium-catalyzed N-(hetero)arylation of a number of heteroarylamines including 2-aminopyridines, 2-aminothiazoles, and their analogues has been realized using Xantphos as the ligand. Weak bases such as CS2CO3, Na2CO3, and K3PO4 were used in most cases to allow for the introduction of functional groups. Choice of the base and solvent was critical for the success of these reactions.
• Some Heterocyclic Secondary Amines¹
  作者：W. K. Detweiler、E. D. Amstutz

  DOI：10.1021/ja01123a503

  日期：1952.2
• Boedeker,J. et al., Journal fur praktische Chemie (Leipzig 1954), 1975, vol. 317, p. 953 - 958
  作者：Boedeker,J. et al.

  DOI：——

  日期：——