α-(Cyanomethyl)ethylacrylat<4-¹⁴C> | 99488-48-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: α-(Cyanomethyl)ethylacrylat<4-¹⁴C>
• 英文别名: ethyl 2-(cyanomethyl)acrylate；2-cyanomethyl propenoic acid ethyl ester；Ethyl 2-(cyanomethyl)prop-2-enoate
• CAS: 99488-48-9
• 化学式: C₇H₉NO₂
• 分子量: 139.154
• InChiKey: GDMKUNOOOCXAIH-UHFFFAOYSA-N

物化性质

• 沸点：
  55 °C(Press: 0.6 Torr)
• 密度：
  1.024±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  50.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  α-(Cyanomethyl)ethylacrylat<4-¹⁴C> 在 溴 作用下， 以 四氯化碳 为溶剂， 生成
  参考文献：
  名称：

  一种有效的2-[（烷基氨基）（氰基）甲基]丙烯酸乙酯的新途径：3-氰基-2-（羟甲基）丙烯酸乙酯的首次合成

  摘要：

  描述了2-（溴甲基）-3-氰基丙烯酸乙酯和伯胺的区域选择性偶联，以良好的产率得到2-[（（烷基氨基）（氰基）甲基]丙烯酸乙酯。而在TEAF存在下烯丙基溴的转化导致3-氰基-2-（羟甲基）丙烯酸乙酯的首次合成。

  DOI：

  10.1016/j.tet.2009.04.028
• 作为产物：
  描述：

  丙二烯 、 氰基甲酸乙酯 在 bis(1,5-cyclooctadiene)nickel (0) 、 二甲基苯基磷 作用下， 以 甲苯 为溶剂， 50.0 ℃ 、101.33 kPa 条件下， 反应 9.0h， 以17%的产率得到α-(Cyanomethyl)ethylacrylat<4-¹⁴C>
  参考文献：
  名称：

  Hirata, Yasuhiro; Inui, Tomohiko; Nakao, Yoshiaki, Journal of the American Chemical Society, 2009, vol. 131, p. 6624 - 6631

  摘要：

  DOI：

文献信息

• SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS
  申请人：Howbert James Jeffry

  公开号：US20110092485A1

  公开（公告）日：2011-04-21

  Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.

  提供的是用于调节Toll样受体(TLR7和/或TLR8)信号传导的组合物和方法。这些组合物和方法在治疗或预防疾病方面具有用途，包括癌症、自身免疫性疾病、传染病、炎症性疾病、移植排斥以及移植物抗宿主病。
• Substituted Benzoazepines as Toll-Like Receptor Modulators
  申请人：ARRAY BIOPHARMA, INC.

  公开号：US20140142086A1

  公开（公告）日：2014-05-22

  Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease.

  提供了对通过Toll样受体TLR7和/或TLR8信号传导进行调节的组合物和方法。这些组合物和方法在治疗或预防疾病方面有用，包括癌症、自身免疫疾病、传染病、炎症性疾病、移植排斥和移植物对宿主病。
• Method for producing thermally crosslinkable polymers in a planetary roller extruder
  申请人：Entex Rust & Mitschke GmbH

  公开号：US11186011B2

  公开（公告）日：2021-11-30

  A method for producing thermally crosslinkable polymers in a planetary roller extruder is presented. The planetary roller extruder has a filling part and a compounding part made of a roller cylinder region that comprises at least two, preferably at least three coupled roller cylinders, planetary spindles of which are driven by a common central spindle. The polymers are supplied in a plasticized state. The filling part is supplied with a vacuum. The flow temperatures of the central spindle and the at least two roller cylinders under a vacuum are set such that the polymers to be degassed remain in the plasticized state. One or more liquids, such as thermal crosslinkers, crosslinking accelerators, dye solutions, or dye dispersions, are metered to the plasticized polymers downstream of the vacuum degassing, preferably in a continuous manner. Finally, the resulting mixture is directly supplied to a coating assembly.

  本发明提出了一种在行星辊挤压机中生产热交联聚合物的方法。行星辊挤压机有一个由辊筒区域组成的填充部分和混料部分，辊筒区域由至少两个，最好是至少三个耦合辊筒组成，辊筒的行星主轴由一个共同的中心主轴驱动。聚合物以塑化状态供应。填充部分为真空状态。中央主轴和至少两个辊筒在真空状态下的流动温度设定为使待脱气的聚合物保持塑化状态。将一种或多种液体，如热交联剂、交联促进剂、染料溶液或染料分散液，计量到真空脱气下游的塑化聚合物中，最好是连续计量。最后，将得到的混合物直接供应给涂层组件。
• Medical articles incorporating surface capillary fiber
  申请人：Ogle F. Matthew

  公开号：US20050021152A1

  公开（公告）日：2005-01-27

  Medical devices are described that comprise surface capillary (SCF) fibers, which can impart desirable properties to the devices. For example, implantable prostheses are described comprising SCF fibers. In other embodiments, catheters are described having SCF fibers along the surface of the catheters. In addition, SCF fibers can be useful for the delivery of bioactive agents in association with the fibers. Due to the fluid flow capabilities of the fibers, medical devices are described that incorporate fiber matrices to facilitate blood delivery to cells within the structure.

  医疗设备包括表面毛细管（SCF）纤维，可赋予设备理想的特性。例如，可植入假体就包含 SCF 纤维。在其他实施方案中，导管的表面也含有 SCF 纤维。此外，SCF 纤维还可用于输送与纤维相关的生物活性剂。由于纤维的流体流动能力，医疗设备的描述中结合了纤维基质，以促进血液输送到结构内的细胞。
• Method of preventing abuse of opioid dosage forms
  申请人：Palermo J. Philip

  公开号：US20050192309A1

  公开（公告）日：2005-09-01

  The invention relates in part to a method of reducing the abuse potential of an oral dosage form of an opioid analgesic, wherein an analgesically effective amount of an orally active opioid agonist is combined with an opioid antagonist into an oral dosage form which would require at least a two-step extraction process to be separated from the opioid agonist, the amount of opioid antagonist including being sufficient to counteract opioid effects if extracted together with the opioid agonist and administered parenterally.

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