(R)-(+)-2,3-epoxypropanoic acid benzyl ester | 118623-64-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-(+)-2,3-epoxypropanoic acid benzyl ester
• 英文别名: Oxiranecarboxylic acid, phenylmethyl ester, (R)-；benzyl (2R)-oxirane-2-carboxylate
• CAS: 118623-64-6
• 化学式: C₁₀H₁₀O₃
• 分子量: 178.188
• InChiKey: LLZMVRSUOWXPTP-SECBINFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (R)-(+)-2,3-epoxypropanoic acid benzyl ester 在 4-二甲氨基吡啶 、 copper(I) bromide dimethylsulfide complex 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 为溶剂， 反应 4.0h， 生成
  参考文献：
  名称：

  使用两种实用方法高效合成莱诺碱结合抑制剂维替尼利

  摘要：

  细胞内Ca +释放通道的ryanodine受体在兴奋性组织中起关键作用。它们代表了极具吸引力的药物靶标，可促进选择性杀虫剂和有用农业化学品的可能发展。对称的24元环状二肽肽verticilide具有选择性抑制ryanodine-ryanodine受体结合的作用。固相肽合成和疏水锚分子工艺是合成此类化合物的实用方法，并且是发现有效的潜在杀虫化合物的有效且经济的方法。在本文中，我们描述了使用这些实用的合成方法进行的凡德来的全合成。

  DOI：

  10.1016/j.tetlet.2020.151699
• 作为产物：
  描述：

  苯甲醇 在 (R,R)-Salen-Co-OTs 、 三乙胺 、 间氯过氧苯甲酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 反应 92.0h， 生成 (R)-(+)-2,3-epoxypropanoic acid benzyl ester
  参考文献：
  名称：

  Synthesis and Characterization of Poly(glyceric Acid Carbonate): A Degradable Analogue of Poly(acrylic Acid)

  摘要：

  The synthesis and characterization of a degradable version of poly(acrylic acid), poly(glyceric acid carbonate), are reported. Specifically, atactic and isotactic poly(benzyl glycidate carbonate)s are obtained via the ring-opening copolymerization of rac-/(R)-benzyl glycidate with CO2 using a bifunctional rac-/(S,S)-cobalt salen catalyst in high carbonate linkage selectivity (>99%) and polymer/cyclic carbonate selectivity (similar to 90%). Atactic poly(benzyl glycidate carbonate) is an amorphous material with a T-g (glass transition temperature) of 44 degrees C, while its isotactic counterpart synthesized from enantiopure epoxide and catalyst is semicrystalline with a T-m (melting temperature) = 87 degrees C. Hydrogenolysis of the resultant polymers affords the poly(glyceric acid carbonate). Poly(glyceric acid carbonate) exhibits an improved cell cytotoxicity profile compared to poly(acrylic acid). Poly(glyceric acid carbonate)s also degrade remarkably fast (t(1/2) approximate to 2 weeks) compared to poly(acrylic acid). Cross-linked hydrogels prepared from poly(glyceric acid carbonate) and poly(ethylene glycol) diaziridine show significant degradation in pH 8.4 aqueous buffer solution compared to similarly prepared hydrogels from poly(acrylic acid) and poly(ethylene glycol) diaziridine.

  DOI：

  10.1021/jacs.5b07911

文献信息

• [EN] SELECTIVE INHIBITORS OF NLRP3 INFLAMMASOME<br/>[FR] INHIBITEURS SÉLECTIFS DE L'INFLAMMASOME NLRP3
  申请人：NODTHERA LTD

  公开号：WO2019025467A1

  公开（公告）日：2019-02-07

  The present disclosure relates to compounds of Formula (I): (I); and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as autoinflammatory and autoimmune diseases and cancers.

  本公开涉及式(I)化合物：(I)；及其药用可接受盐、药物组合物、使用方法和制备方法。所公开的化合物可用于通过抑制炎症小体来抑制IL-1家族细胞因子的成熟，并可用于治疗炎症小体活性涉及的疾病，如自炎性和自身免疫疾病以及癌症。
• NOVEL ORGANOSELENIUM COMPOUNDS, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL USES THEREOF IN PARTICULAR AS ANTITUMOR AGENTS
  申请人：TETRAHEDRON

  公开号：US20170114011A1

  公开（公告）日：2017-04-27

  The invention relates to a selenium compound. Said selenium compound has formula (I), where R 1 =alkyl; R 2 =H, R 4 C(=0), R 4 OC(=0), a-aminoacyl, CH 3 SeCH 2 CH 2 CH(NH 2 )C(=0), CH 3 SeCH 2 CH 2 CH(OH)C(=0); X=OH, OR 3 , NH 2 , NR 4 R 5 , α-amino acid, CH 3 SeCH 2 CH 2 CH(COOH)NH—, CH 3 SeCH 2 CH 2 CH(COOH)0-; R 3 =alkyl; R 4 =alkyl, aryl; R 5 =H, alkyl, aryl; R 4 and R 5 which can together form a 5- or 6-membered cycloalkyl radical which can comprise a heteroatom; provided that when X=NH-terbutyl, R 2 ≠C(=0)CH 3 . Said compound can be used as a pharmaceutical substance, in particular as an antitumour substance.

  该发明涉及一种硒化合物。所述硒化合物的化学式为(I)，其中R1=烷基；R2=H，R4C(=0)，R4OC(=0)，a-氨基酰基，CH3SeCH2CH2CH(NH2)C(=0)，CH3SeCH2CH2CH(OH)C(=0)；X=OH，OR3，NH2，NR4R5，α-氨基酸，CH3SeCH2CH2CH(COOH)NH—，CH3SeCH2CH2CH(COOH)0-；R3=烷基；R4=烷基，芳基；R5=H，烷基，芳基；R4和R5可以共同形成一个含有杂原子的5-或6-成员环烷基基团；但当X=NH-terbutyl时，R2≠C(=0)CH3。该化合物可用作药物物质，特别是作为抗肿瘤物质。
• 신규한 환상 뎁시펩티드 유도체 및 이를 포함하는 해충 방제제
  申请人：Meiji Seika Pharma Co., Ltd. 메이지 세이카 파루마 가부시키가이샤(519990487541)

  公开号：KR20150037766A

  公开（公告）日：2015-04-08

  본 발명의 목적은 신규한 환상 뎁시펩티드 유도체 및 그것을 포함하는 유해 생물 방제제를 제공하는 것이다. 구체적으로, 본 발명은 식(1)으로 나타내어지는 화합물 또는 그의 입체 이성체, 그들을 포함하는 유해 생물 방제제, 및 그들의 제조방법을 제공한다.

  本发明的目的是提供一种新的幻想深度肽诱导剂及其包含的有害生物防治剂。具体而言，本发明提供了化合物或其立体异构体，其表示为式（1），包含它们的有害生物防治剂以及它们的制备方法。
• NOVEL CYCLIC DEPSIPEPTIDE DERIVATIVES AND HARMFUL ORGANISM CONTROL AGENTS COMPRISING THE SAME
  申请人：Meiji Seika Pharma Co., Ltd.

  公开号：US20170215422A1

  公开（公告）日：2017-08-03

  An objective of the present invention is to provide novel cyclic depsipeptide derivatives and harmful organism control agents including the same as each other. Specifically, the present invention provides compounds represented by formula (1) or stereoisomers thereof, harmful organism control agents containing them, and a process for producing them.

  本发明的目标是提供新型的环状脱氨肽衍生物和包括它们的有害生物控制剂。具体而言，本发明提供由公式（1）或其立体异构体表示的化合物，包含它们的有害生物控制剂，以及生产它们的方法。
• A simple preparation of R or S glycidic esters; Application to the synthesis of enantiomerically pure α-hydroxyesters.
  作者：Marc Larchevêque、Yves Petit

  DOI：10.1016/s0040-4039(00)96028-3

  日期：1987.1

  The simple preparation of enantiomerically pure α-hydroxyesters by the régioselective reaction of lithio and magnesiocuprates with glycidic esters or ′ readily available from serine is described.

  描述了通过硫代和镁代高铁酸盐与容易从丝氨酸获得的缩水甘油酯或′的区域选择性反应来简单制备对映体纯的α-羟基酯的方法。