1,2-dihydro-5,7-dimethoxy-3,1-benzoxazine-2,4-dione | 63920-75-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 1,2-dihydro-5,7-dimethoxy-3,1-benzoxazine-2,4-dione
• 英文别名: dimethoxy isatoic anhydride；4,6-dimethoxyisatoic anhydride；5,7-dimethoxy-1H-benzo[d][1,3]oxazine-2,4-dione；5,7-dimethoxy-2H-3,1-benzoxazine-2,4(1H)-dione；5,7-dimethoxy-1H-3,1-benzoxazine-2,4-dione
• CAS: 63920-75-2
• 化学式: C₁₀H₉NO₅
• 分子量: 223.185
• InChiKey: UZEFANXQRVBAGI-UHFFFAOYSA-N

物化性质

• 熔点：
  287-293 °C (decomp)
• 密度：
  1.358±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  73.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1,2-dihydro-5,7-dimethoxy-3,1-benzoxazine-2,4-dione 在 palladium diacetate 、 二苯基丙基膦 4-二甲氨基吡啶 、 三溴化硼 、 sodium hydride 、 三乙胺 作用下， 以 二氯甲烷 、 异丁酰胺 、 二甲基亚砜 、 N,N-二甲基甲酰胺 为溶剂， 反应 53.83h， 生成 Methyl 7-methoxy-3-(4-methoxyphenyl)-4-oxoquinazoline-5-carboxylate
  参考文献：
  名称：

  WO2006/116401

  摘要：

  公开号：
• 作为产物：
  描述：

  3,5-二甲氧基苯胺盐酸盐 在 sodium hydroxide 、 双氧水 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 1,2-dihydro-5,7-dimethoxy-3,1-benzoxazine-2,4-dione
  参考文献：
  名称：

  3-Arylquinazoline derivatives as selective estrogen receptor beta modulators

  摘要：

  提供具有雌激素受体β（ERβ）调节活性的新型喹唑啉衍生物，其具有一般式I1，其中X为O或S；A和B分别为CR′″或N；R、R′和R″分别为氢、烷基、苄基、对甲氧基苄基、烯丙基或Si（R4）3，其中至少有一个为氢；R′″为氢、卤素、CF3、OR5、S（O）nR6、NR7R8、环烷基或烷基；R1、R2和R3分别为氢、卤素、CF3、OR5、S（O）nR6、NR7R8、环烷基或烷基；R4为烷基；R5、R6、R7和R8在每个官能团中分别为氢、环烷基或烷基；n为0至2的整数。此外，提供一种用于预防、抑制或治疗与雌激素受体相关的病理状况进展或发作的方法，以及含有这类化合物的药物组合物。

  公开号：

  US20030220227A1

文献信息

• PYRAZOLOQUINOLONE DERIVATIVE AND USE THEREOF
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1719771A1

  公开（公告）日：2006-11-08

  The present invention provides a pyarzoloquinolone derivative having kinase inhibitory activity. The derivative is represented by the formula: wherein R1 is an aryl group which may be substituted, or an aromatic heterocyclic group which may be substituted; R2 is a hydrogen atom, an amino group which may be substituted, a hydroxy group which may be substituted, or a thiol group which may be substituted; R3, R4, R5 and R6, which may be identical or different, are each (1) a hydrogen atom, (2) a nitro group, (3) a cyano group, (4) a halogen atom, (5) a hydrocarbon group which may be substituted, (6) an amino group which may be substituted, (7) a hydroxy group which may be substituted, or (8) a thiol group which may be substituted; and R3 and R4, R4 and R5, and R5 and R6 may respectively form a ring together with the adjacent carbon atom, or salt thereof.

  本发明提供了一种具有激酶抑制活性的吡唑喹啉衍生物。该衍生物由以下式表示： 其中R1是可以被取代的芳基或可以被取代的芳香杂环基；R2是氢原子、可以被取代的氨基、可以被取代的羟基或可以被取代的硫基；R3、R4、R5和R6，可以相同也可以不同，分别是（1）氢原子、（2）硝基、（3）氰基、（4）卤原子、（5）可以被取代的碳氢基、（6）可以被取代的氨基、（7）可以被取代的羟基或（8）可以被取代的硫基；且R3和R4、R4和R5、以及R5和R6可以分别与相邻的碳原子形成环，或其盐。
• Oxamic acid derivatives
  申请人：American Home Products Corporation

  公开号：US04154961A1

  公开（公告）日：1979-05-15

  Anti-allergic agents of aromatic oxamic acid derivation present the following formula: ##STR1## in which A is a member selected from the group consisting of .alpha.-naphthyl, .beta.-naphthyl, phenyl, 2,6-di-chlorophenyl, and substituted phenyl moieties containing from one to three substituents in any of the 2,3,4 and 5 positions of the phenyl ring, independently selected from the group consisting of lower alkyl, lower alkylthio, lower alkylsulfinyl, lower alkoxy, hydroxy (lower)alkoxy, 2-(oxalyloxy) ethoxy, benzyloxy, N-mono- and di-lower alkylamino(lower)alkoxy, halo, sulfamyl, polyhalo(lower)alkyl, carbamyl, N-lower alkylcarbamyl, nitro, mono and di lower alkylamino, carboxy, lower alkylcarbonyl, carb(lower)alkoxy, phenoxy(lower)alkoxy, and oxalamidophenoxy radicals; And pharmaceutically acceptable salts thereof.

  芳香族羧酸衍生物的抗过敏药物具有以下化学式：##STR1## 其中 A 是从以下组成的成员中选择的：α-萘基、β-萘基、苯基、2,6-二氯苯基和含有1至3个取代基的苯基基团，这些取代基可以独立地选择自以下组成的取代基：低烷基、低硫代烷基、低烷基磺基、低烷氧基、羟基（低）烷氧基、2-(草酰氧基)乙氧基、苄氧基、N-单-和双-低烷基氨基（低）烷氧基、卤素、磺酰胺基、多卤素（低）烷基、氨基甲酰基、N-低烷基氨基甲酰基、硝基、单和双低烷基氨基、羧基、低烷基羰基、氨基（低）羧基、苯氧基（低）烷氧基和草酰胺基苯氧基基团；以及其药用可接受的盐。
• Pyridyl oxamic acid derivatives and use in the prevention of allergic
  申请人：American Home Products Corporation

  公开号：US04054661A1

  公开（公告）日：1977-10-18

  Anti-allergic agents of aromatic and heterocyclic oxamic acid derivation present the following formula: ##STR1## in which A is a member selected from the group consisting of 2-thiazolyl, 2-pyridyl, 2-pyridyl-N-oxide, 6-(lower)alkyl-2-pyridyl, 3-cyano-2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 2-pyrazinyl, .alpha.-naphthyl, .beta.naphthyl, phenyl, 2,6-dichlorophenyl, and substituted phenyl moieties containing from one to three substituents in any of the 2,3,4 and 5 positions of the phenyl ring, independently selected from the group consisting of lower alkyl, lower alkylthio, lower alkylsulfinyl, lower alkoxy, hydroxy(lower)-alkoxy, 2-(lower alkoxy oxalyloxy) ethoxy, benzyloxy, N-mono-and di-lower alkylamino(lower)-alkoxy, halo, sulfamyl, polyhalo(lower)alkyl, carbamyl, N-lower alkylcarbamyl, nitro, mono-and di-lower alkylamino, phenylazo, carboxy, lower alkylcarbonyl, cyano, carb(lower)alkoxy, phenoxy(lower)alkoxy, lower alkoxyoxalamido and lower alkoxyoxalamidophenoxy radicals; B, when taken alone, is a member selected from the group consisting of --OH, lower alkoxy, --NH.sub.2, --NHOH, cyclohexyloxy and phenoxy; and Y is a member selected from the group consisting of oxygen and when taken with B and the carbon atom to which they are attached, forms the moiety ##STR2##

  芳香族和杂环氧酰胺衍生的抗过敏剂具有以下公式：##STR1## 其中A是从2-噻唑基，2-吡啶基，2-吡啶基-N-氧化物，6-（较低）烷基-2-吡啶基，3-氰基-2-吡啶基，3-吡啶基，4-吡啶基，2-吡嘧啶基，2-吡嗪基，α-萘基，β-萘基，苯基，2,6-二氯苯基和取代苯基中选择的一种成员，所述取代苯基包含一个到三个取代基，所述取代基独立地选择自较低烷基，较低硫代烷基，较低磺代烷基，较低烷氧基，羟基（较低）-烷氧基，2-（较低烷氧基氧乙酰氧基）乙氧基，苄氧基，N-单和二-较低烷基氨基（较低）-烷氧基，卤，磺酰胺，多卤（较低）烷基，氨基甲酰，N-较低烷基氨基甲酰，硝基，单和二-较低烷基氨基，苯基偶氮，羧基，较低烷基羰基，氰基，羰基（较低）烷氧基，苯氧基（较低）烷氧基，较低烷氧基草酰胺基和较低烷氧基草酰胺基苯氧自由基；B，单独时，是从-OH，较低烷氧，-NH.sub.2，-NHOH，环己氧基和苯氧基中选择的一种成员；Y是从氧中选择的一种成员，当与B和它们连接的碳原子一起被选取时，形成如下部分：##STR2##
• Oxamic acid derivatives for the prevention of immediate type
  申请人：American Home Products Corporation

  公开号：US03966965A1

  公开（公告）日：1976-06-29

  Anti-allergic agents of ##EQU1## and heterocyclic oxamic acid derivation present the following formula: IN WHICH A is a member selected from the group consisting of 2-thiazolyl, 2-pyridyl, 2-pyridyl-N-oxide, 6-(lower)alkyl-2-pyridyl, 3-cyano-2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 2-pyrazinyl, .alpha.-naphthyl, .beta.-naphthyl, phenyl, 2,6-dichlorophenyl, and substituted phenyl moieties containing from one to three substituents in any of the 2,3,4 and 5 positions of the phenyl ring, independently selected from the group consisting of lower alkyl, lower alkylthio, lower alkylsulfinyl, lower alkoxy, hydroxy(lower)-alkoxy, 2-(lower alkoxy oxalyloxy) ethoxy, benzyloxy, N-mono-and di-lower alkylamino(lower)-alkoxy, halo, sulfamyl, polyhalo(lower)alkyl, carbamyl, N-lower alkylcarbamyl, nitro, mono- and di-lower alkylamino, phenylazo, carboxy, lower alkylcarbonyl, cyano, carb(lower)alkoxy, phenoxy(lower)alkoxy, lower alkoxyoxalamido and lower alkoxyoxalamidophenoxy radicals; B, when taken alone, is a member selected from the group consisting of -OH, lower alkoxy, --NH.sub.2, --NHOH, cyclohexyloxy and phenoxy; and Y is a member selected from the group consisting of oxygen and when taken with B and the carbon atom to which they are attached, forms the moiety ##EQU2##

  ##EQU1##的抗过敏剂和杂环氧酰胺衍生物具有以下公式：其中A是从2-噻唑基，2-吡啶基，2-吡啶-N-氧化物，6-（较低）烷基-2-吡啶基，3-氰基-2-吡啶基，3-吡啶基，4-吡啶基，2-吡嘧啶基，2-吡啶基，α-萘基，β-萘基，苯基，2,6-二氯苯基和取代苯基等组成的群中选择的成员，其中该苯环的2,3,4和5位置中的任意位置都包含从一个到三个取代基的取代基，这些取代基独立地从较低烷基，较低硫代烷基，较低磺酰基，较低烷氧基，羟基（较低）-烷氧基，2-（较低烷氧基氧代羰基）乙氧基，苄氧基，N-单和二-较低烷基氨基（较低）-烷氧基，卤素，磺酰基，多卤代（较低）烷基，氨基甲酰基，N-较低烷基氨基甲酰基，硝基，单和双-较低烷基氨基，苯基偶氮基，羧基，较低烷基羰基，氰基，羰基（较低）烷氧基，苯氧基（较低）烷氧基，较低烷氧氧代草酰胺基和较低烷氧氧代草酰胺苯氧基自由基；B，当单独取时，是从-OH，较低烷氧基，-NH.sub.2，-NHOH，环己氧基和苯氧基等组成的群中选择的成员；Y是从氧中选择的成员，当与B和它们连接的碳原子一起取时，形成上述公式。
• COMPOUNDS USEFUL IN THE SYNTHESIS OF BENZAMIDE COMPOUNDS
  申请人：Lozanov Mario Emilov

  公开号：US20140107369A1

  公开（公告）日：2014-04-17

  Compounds that are useful in the synthesis of 2-amino-4,6-dimethoxybenzamide derivatives and other benzamide compounds.

  这是一句英文句子，翻译成中文为：化合物可用于合成2-氨基-4,6-二甲氧基苯甲酰胺衍生物和其他苯甲酰胺类化合物。