1-碘-4-(4-甲氧基苯氧基)苯 | 26002-36-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-碘-4-(4-甲氧基苯氧基)苯
• 英文名称: 1-iodo-4-(4-methoxyphenoxy)benzene
• 英文别名: 1-(4-iodo-phenoxy)-4-methoxy-benzene；O-Methyl-O'-(4-jod-phenyl)-hydrochinon；1-(4-Jod-phenoxy)-4-methoxy-benzol；4-(4-iodophenoxy)-(methoxy)benzene；1-Iodo-4-(4-methoxyphenoxy)-benzene
• CAS: 26002-36-8
• 化学式: C₁₃H₁₁IO₂
• mdl: MFCD06796300
• 分子量: 326.134
• InChiKey: SGURKGRRNWCMQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.076
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-碘-4-(4-甲氧基苯氧基)苯 在 硝酸 、 铁粉 、 溶剂黄146 作用下， 生成 5-(4-iodo-phenoxy)-2-methoxy-aniline
  参考文献：
  名称：

  Iodo Derivatives of Phenyl Ether. II. Studies in Orientation

  摘要：

  DOI：

  10.1021/ja01265a038
• 作为产物：
  描述：

  [4-(4-甲氧基苯氧基)苯基]胺 生成 1-碘-4-(4-甲氧基苯氧基)苯
  参考文献：
  名称：

  Iodo Derivatives of Phenyl Ether. II. Studies in Orientation

  摘要：

  DOI：

  10.1021/ja01265a038

文献信息

• Triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors
  申请人：——

  公开号：US20040006057A1

  公开（公告）日：2004-01-08

  The present invention relates to triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione; metalloproteinase inhibitors of the formula 1 wherein X, A, Y, B, G, W, and R 1 are as defined in the specification, and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders.

  本发明涉及三芳基氧基吡啶二酮类金属蛋白酶抑制剂，其化学式为1，其中X、A、Y、B、G、W和R1如规范中所定义，并涉及用于治疗炎症、癌症和其他疾病的药物组合物和方法。
• 2-AMINONICOTINIC ACID ESTER DERIVATIVE AND BACTERICIDE CONTAINING SAME AS ACTIVE INGREDIENT
  申请人：Agro-Kanesho Co., Ltd.

  公开号：EP2871180A1

  公开（公告）日：2015-05-13

  The present invention provides a bactericide containing a 2-aminonicotinic acid ester derivative as an active ingredient. The active ingredient is represented by the following formula [I] : (wherein, R1 represents a hydrogen atom or a C1-C4 alkyl group, R2 represents a hydrogen atom or a C1-C4 alkyl group, R1 and R2 may be combined together to form an alkylene chain, R3 represents a hydrogen atom or a C1-C4 alkyl group, R4 represents a hydrogen atom, a cyano group or a C1-C4 alkyl group, R5 and R6 independently represent a hydrogen atom, a halogen atom, a C1-C4 alkyl group, a C1-C4 alkoxy group, a C1-C4 alkylthio group, a C1-C4 alkylsulfinyl group, a C1-C4 alkylsulfonyl group, a nitro group, a cyano group, a C1-C4 haloalkyl group, a C1-C4 haloalkoxy group or a C1-C4 haloalkylthio group, A and B independently represent a methine (CH) group or a nitrogen atom).

  本发明提供了一种含有 2-氨基烟酸酯衍生物作为活性成分的杀菌剂。 活性成分由下式[I]表示： (其中，R1 代表氢原子或 C1-C4 烷基，R2 代表氢原子或 C1-C4 烷基，R1 和 R2 可结合在一起形成亚烷基链，R3 代表氢原子或 C1-C4 烷基，R4 代表氢原子、氰基或 C1-C4 烷基，R5 和 R6 独立地代表氢原子、卤素原子、C1-C4 烷基、C1-C4 烷氧基、C1-C4 硫代烷基、C1-C4 亚烷基、C1-C4 亚烷基磺酰基、硝基、氰基、C1-C4 卤代烷基、C1-C4 卤代烷氧基或 C1-C4 卤代硫代烷基，A 和 B 独立地代表甲烷 (CH) 基团或氮原子）。
• Metalation and Halogen-Metal Interconversion Reactions of Some Halogenated Phenyl Ethers
  作者：Wright Langham、R. Q. Brewster、Henry Gilman

  DOI：10.1021/ja01847a053

  日期：1941.2
• Potent, selective pyrimidinetrione-based inhibitors of MMP-13
  作者：Lawrence A. Reiter、Kevin D. Freeman-Cook、Christopher S. Jones、Gary J. Martinelli、Amy S. Antipas、Martin A. Berliner、Kaushik Datta、James T. Downs、James D. Eskra、Michael D. Forman、Elaine M. Greer、Roberto Guzman、Joel R. Hardink、Fouad Janat、Nandell F. Keene、Ellen R. Laird、Jennifer L. Liras、Lori L. Lopresti-Morrow、Peter G. Mitchell、Jayvardhan Pandit、Donald Robertson、Diana Sperger、Marcie L. Vaughn-Bowser、Darra M. Waller、Sue A. Yocum

  DOI：10.1016/j.bmcl.2006.08.066

  日期：2006.11

  Using SAR from two related series of pyrimidinetrione-based inhibitors, compounds with potent MMP-13 inhibition and > 100-fold selectivity against other MMPs have been identified. Despite high molecular weights, c log Ps, and polar surface areas, the compounds are generally well absorbed and have excellent pharmacokinetic (PK) properties when dosed as sodium salts. In a rat fibrosis model, a compound from the series displayed no fibrosis at exposures many fold greater than its MMP-13 IC50. (c) 2006 Elsevier Ltd. All rights reserved.
• TRIARYL-OXY-ARYLOXY-PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS
  申请人：Pfizer Products Inc.

  公开号：EP1501515B1

  公开（公告）日：2005-11-02