3-(prop-1-en-2-yl)phenol | 51985-06-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(prop-1-en-2-yl)phenol
• 英文别名: 3-hydroxy-alpha-methylstyrene；3-prop-1-en-2-ylphenol
• CAS: 51985-06-9
• 化学式: C₉H₁₀O
• 分子量: 134.178
• InChiKey: REWLXMVGEZMKSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2907199090

反应信息

• 作为反应物：
  描述：

  3-(prop-1-en-2-yl)phenol 在 sodium azide 、 硫酸 、 sodium hydroxide 作用下， 以 正己烷 、 水 为溶剂， 反应 4.33h， 以40%的产率得到3-氨基苯酚
  参考文献：
  名称：

  アミノ芳香族化合物の製造方法

  摘要：

  这段文本的中文翻译如下：【问题】提供一种新的氨基芳香族化合物的制备方法。【解决方案】包括至少含有一个芳香环及该芳香环上至少含有一个基团被表示为−CR=CH2〔其中，R表示氢原子或烷基，烷基的碳数为1〜3〕的化合物（A）与亚硝酸钠在酸的存在下反应的步骤，至少包括制备含有芳香环上至少一个氨基的化合物（B）的方法。【选择图】无

  公开号：

  JP2021031414A
• 作为产物：
  描述：

  3-异丙基苯酚 在 iron(III) oxide 、 steam 、 magnesium oxide 作用下， 生成 3-(prop-1-en-2-yl)phenol
  参考文献：
  名称：

  Preparation of Vinylphenols and Isopropenylphenols

  摘要：

  DOI：

  10.1021/jo01098a012

文献信息

• Visible-Light-Promoted Metal-Free Aerobic Hydroxyazidation of Alkenes
  作者：Bo Yang、Zhan Lu

  DOI：10.1021/acscatal.7b02892

  日期：2017.12.1

  A highly efficient visible-light-promoted metal-free aerobic hydroxyazidation of alkenes has been developed. This protocol was operationally simple with broad substrate scope using relatively simple and readily available starting materials, such as alkenes and air, to construct valuable β-azido alcohols which are significant building blocks to build N-containing compounds. The distinct possible mechanisms

  已经开发了高效的可见光促进的烯烃的无金属需氧羟基叠氮化。该方案操作简单，具有广泛的底物范围，使用相对简单且容易获得的起始原料（例如烯烃和空气）来构建有价值的β-叠氮基醇，这是构建含N化合物的重要基础。通过叠氮基和烯基阳离子的产生，提出了不同的可能机理。
• TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS
  申请人：Arvinas, Inc.

  公开号：US20180155322A1

  公开（公告）日：2018-06-07

  The present disclosure relates to bifunctional compounds, which find utility as modulators of estrogen receptor (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end at least one of a Von Hippel-Lindau ligand, a cereblon ligand, Inhibitors of Apoptosis Proteins ligand, mouse double-minute homolog 2 ligand, or a combination thereof, which binds to the respective E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

  本公开涉及双功能化合物，这些化合物可用作雌激素受体（目标蛋白）的调节剂。特别是，本公开涉及包含在一段至少有一种Von Hippel-Lindau配体、一种cereblon配体、凋亡抑制蛋白配体、小鼠双分钟同源2配体或其组合的双功能化合物，这些配体与相应的E3泛素连接酶结合，在另一端有一个与目标蛋白结合的部分，使得目标蛋白被置于泛素连接酶附近，以实现目标蛋白的降解（和抑制）。本公开展示了与目标蛋白降解/抑制相关的广泛药理活性。可以通过本公开的化合物和组合物治疗或预防由目标蛋白聚集或积累引起的疾病或障碍。
• [EN] HYDROXY-SUBSTITUTED OREXIN RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DES RÉCEPTEURS DE L'OREXINE SUBSTITUÉS PAR UN GROUPE HYDROXY
  申请人：MERCK SHARP & DOHME

  公开号：WO2014176142A1

  公开（公告）日：2014-10-30

  The present invention is directed to hydroxy compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及对促进素受体的拮抗剂的羟基化合物。本发明还涉及所述化合物在潜在治疗或预防涉及促进素受体的神经和精神障碍和疾病中的用途。本发明还涉及包含这些化合物的药物组合物。本发明还涉及这些药物组合物在预防或治疗涉及促进素受体的疾病中的用途。
• PHOTORESIST COMPOSITION, RESIST-PATTERN FORMING METHOD, POLYMER, AND COMPOUND
  申请人：SATO Mitsuo

  公开号：US20120258402A1

  公开（公告）日：2012-10-11

  A photoresist composition includes a polymer that includes a structural unit shown by the following formula (1), and a photoacid generator. R 1 in the formula (1) represents a hydrogen atom, a fluorine atom, a methyl group, or a trifluoromethyl group, Z represents a group that forms a divalent alicyclic group having 3 to 20 carbon atoms together with a carbon atom bonded to X, X represents an alkanediyl group having 1 to 6 carbon atoms, Y represents a hydrogen atom or —CR 2 R 3 (OR 4 ), and R 2 to R 4 independently represent a hydrogen atom or a monovalent hydrocarbon group, provided that R 3 and R 4 optionally bond to each other to form a cyclic ether structure together with a carbon atom bonded to R 3 and an oxygen atom bonded to R 4 .

  一种光阻剂组合物包括一个聚合物，该聚合物包括下式（1）所示的结构单元，以及一个光酸发生剂。在式（1）中，R1代表氢原子、氟原子、甲基基团或三氟甲基基团，Z代表与与X键合的碳原子一起形成具有3到20个碳原子的二价脂环族基团，X代表具有1到6个碳原子的脂肪二基基团，Y代表氢原子或—CR2R3(OR4)，R2到R4独立地代表氢原子或一价烃基团，其中R3和R4可选择地相互键合以与与R3键合的碳原子和与R4键合的氧原子一起形成环状醚结构。
• Identification of Chlamydia pneumoniae DNA in Carotid Plaques
  作者：Fabio Chierichetti、Eloise Arbustini、Vittorio Arici、Shahdeh Parsapour Moghadam、Barbara Conti、Attilia Bagliani

  DOI：10.1177/000331970005101004

  日期：2000.10

  Chlamydia pneumoniae (CP) is a bacterium that in recent years has been investigated as an etiologic agent for atherosclerosis. It is a ubiquitous microorganism that has been isolated in various regions of the vascular system and its prevalence is about 10% in the patient population. This study involved a group of 43 patients (27 men, 16 women, mean age 68 years) who underwent carotid endarterectomy

  肺炎衣原体（CP）是一种细菌，近年来已被研究为动脉粥样硬化的病原体。它是一种普遍存在的微生物，已在血管系统的各个区域分离出来，其患病率在患者人群中约为10％。这项研究涉及一组43例接受了颈动脉内膜切除术的患者（27例男性，16例女性，平均年龄68岁）。约9.3％的患者产生的斑块对肺炎衣原体的DNA基因组呈阳性。