Benzyloxycarbonylglycin-isobutylamid | 100876-29-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Benzyloxycarbonylglycin-isobutylamid
• 英文别名: Benzyl (2-(isobutylamino)-2-oxoethyl)carbamate；benzyl N-[2-(2-methylpropylamino)-2-oxoethyl]carbamate
• CAS: 100876-29-7
• 化学式: C₁₄H₂₀N₂O₃
• 分子量: 264.324
• InChiKey: UJHLYZHNSNWIPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Benzyloxycarbonylglycin-isobutylamid 在 palladium 10% on activated carbon 、 氢气 、 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 15.0h， 生成 3,4-bis(benzyloxy)-N-(2-(isobutylamino)-2-oxoethyl)picolinamide
  参考文献：
  名称：

  Synthesis, physical–chemical characterisation and biological evaluation of novel 2-amido-3-hydroxypyridin-4(1H)-ones: Iron chelators with the potential for treating Alzheimer’s disease

  摘要：

  A novel class of 2-amido-3-hydroxypyridin-4-one iron chelators is described. These compounds have been designed to behave as suitable molecular probes which will improve our knowledge of the role of iron in neurodegenerative conditions. Neurodegenerative disorders, such as Alzheimer's disease (AD) and Parkinson disease (PD), can be considered as diverse pathological conditions sharing critical metabolic processes such as protein aggregation and oxidative stress. Interestingly, both these metabolic alterations seem to be associated with the involvement of metal ions, including iron. Iron chelation is therefore a potential therapeutic approach. The physico-chemical (pK(a) pFe(3+) and log P) and biological properties (inhibition of iron-containing enzymes) of these chelators have been investigated in order to obtain a suitable profile for the treatment of neurodegenerative conditions. Studies with neuronal cell cultures confirm that the new iron chelators are neuroprotective against beta-amyloid-induced toxicity. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.12.007
• 作为产物：
  描述：

  N-苄氧羰基甘氨酰胺 在 2-萘磺酸 作用下， 生成 Benzyloxycarbonylglycin-isobutylamid
  参考文献：
  名称：

  The Reactions of Carbobenzoxyamino Acid Amides with Carbonyl Compounds

  摘要：

  DOI：

  10.1021/jo01063a029

文献信息

• Chemical processes generating solid(s) carried out continuously within microreactors
  申请人：Corning Incorporated

  公开号：EP2409982A2

  公开（公告）日：2012-01-25

  The present invention relates to a continuous process for conducting a chemical reaction in a liquid reaction medium. Characteristically: - said continuous process is carried out in a microreactor (10), - said chemical reaction produces a solid insoluble in said liquid reaction medium, and - said continuous process comprises the continuous extraction of said solid, as it is produced, with a solvent S2, immiscible with said reaction medium. Such a process is advantageously carried out for conducting the activation of a carboxylic acid in the presence of an organic base.

  本发明涉及一种在液体反应介质中进行化学反应的连续工艺。其特点是 - 所述连续工艺在微反应器（10）中进行、 - 所述化学反应产生不溶于所述液体反应介质的固体，以及 - 所述连续工艺包括在产生所述固体时，用与所述反应介质不相溶的溶剂 S2 对其进行连续萃取。 这种工艺有利于在有机碱存在下进行羧酸活化。