4-ethoxy-2-chloro-5-methyl-aniline | 861008-02-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-ethoxy-2-chloro-5-methyl-aniline
• 英文别名: 4-Aethoxy-2-chlor-5-methyl-anilin；2-Chloro-4-ethoxy-5-methylaniline；2-chloro-4-ethoxy-5-methylaniline
• CAS: 861008-02-8
• 化学式: C₉H₁₂ClNO
• 分子量: 185.653
• InChiKey: AOLFNIBLSUQJGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  苯酐 、 4-ethoxy-2-chloro-5-methyl-aniline 生成 N-(4-ethoxy-2-chloro-5-methyl-phenyl)-phthalimide
  参考文献：
  名称：

  Angeletti; Oliverio, Gazzetta Chimica Italiana, 1940, vol. 70, p. 789,792

  摘要：

  DOI：
• 作为产物：
  描述：

  乙醇 、 6-甲基孕烯醇酮 在 盐酸 作用下， 生成 4-ethoxy-2-chloro-5-methyl-aniline
  参考文献：
  名称：

  Angeletti; Oliverio, Gazzetta Chimica Italiana, 1940, vol. 70, p. 789,792

  摘要：

  DOI：

文献信息

• 1,5-DIHYDRO-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MODULATORS FOR THE TREATMENT OF CNS DISORDERS
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2217602B1

  公开（公告）日：2018-08-29
• 1, 5-DIHYDRO-PYRAZOLO (3, 4-D) PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MUDULATORS FOR THE TREATMENT OF CNS DISORDERS
  申请人：Eickmeier Christian

  公开号：US20110015193A1

  公开（公告）日：2011-01-20

  The invention relates to novel substituted pyrazolopyrimidines. Chemically, the compounds are characterised by general Formula (I): with R 1 being phenyl or pyridyl, any of which is substituted with 1 to 4, preferably 1 to 3 substituents X; X independently of each other being selected from C 2 -C 6 -alky 1 or Ci-C 6 -alkoxy, where C 2 -C 6 -alkyl and C 1 -C 6 -alkoxy are at least dihalogenated up to perhalogenated. preferably with 2 to 6 halogen substituents, and the halogen atoms being selected from the group of fluoro, chloro and bromo, preferably fluoro; R 2 being phenyl or heteroaryl, where phenyl is substituted by 1 to 3 radicals and heteroaryl is optionally substituted by 1 to 3 radicals in each case independently of one another selected from the group of C 1 -C 6 -alkyI, C 1 -C 6 -alkoxy, hydroxycarbonyl, cyano, trifluoromethyl, amino, nitro, hydroxy, C 1 -C 6 -alkylamino, halogen, C 6 -C 10 -arylcarbonylamino, C 1 -C 6 -alkylcarbonylamino, C 1 -C 6 -alkylaminocarbonyl. C 1 -C 6 -alkoxycarbonyl, C 6 -C 10 -arylaminocarbonyl, heteroarylaminocarbonyl. heteroarylcarbonylamino, C 1 -C 6 -alkylsulphonyl-amino, C 1 -C 6 -alkylsulphonyl and C 1 -C 6 -alkylthio; The new compounds shall be used for the manufacture of medicaments, in particular medicaments for improving, perception, concentration, learning and/or memory in patients in need thereof.
• US8648085B2
  申请人：——

  公开号：US8648085B2

  公开（公告）日：2014-02-11
• Angeletti; Oliverio, Gazzetta Chimica Italiana, 1940, vol. 70, p. 789,792
  作者：Angeletti、Oliverio

  DOI：——

  日期：——