三(3-甲基苄基)胺 | 64309-89-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 三(3-甲基苄基)胺
• 英文名称: tris(3-methylbenzyl)amine
• 英文别名: 1-(3-methylphenyl)-N,N-bis[(3-methylphenyl)methyl]methanamine
• CAS: 64309-89-3
• 化学式: C₂₄H₂₇N
• 分子量: 329.485
• InChiKey: PGXOKCQQTBYQIY-UHFFFAOYSA-N

物化性质

• 沸点：
  435.4±14.0 °C(Predicted)
• 密度：
  1.041±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  三(3-甲基苄基)胺 、 alkaline earth salt of/the/ methylsulfuric acid 生成 双(3-甲基苄基)胺 、 3-甲基苯甲醛
  参考文献：
  名称：

  Cyclone Mitigation, Resource Allocation and Post-disaster Reconstruction in South India: Lessons from Two Decades of Research

  摘要：

  This paper opens with a history of development and disaster‐prevention strategies in a cyclone‐prone area of the east coast of India and traces the evolution in the area of British and Indian governments' programmes and policy over a century. Research over the last 20 years has shown however that the programmes and policies have failed to balance economic growth with safety. Resources intended for the benefit of all have been diverted by alliances of powerful people to a small minority, and recent developments have reduced the physical protection of the area. The result is that increasing numbers of people are vulnerable to the effects of cyclones and floods. The findings suggest that the best way to reduce vulnerability is to improve the socio‐economic standing of the most vulnerable and for this to happen these people must have an assured income based on assets that will enable them to acquire social and economic credit‐worthiness within the local economy. This paper presents evidence that suggests that non‐governmental organisation (NGO)‐supported co‐operatives are the best way to achieve this through self‐help and self‐employment schemes. It also suggests that NGOs should be encouraged to take up environmentally and ecologically beneficial activities involving the poorest groups in the communities, in this way combining sustained self‐employment with environmental protection.

  DOI：

  10.1111/1467-7717.00129
• 作为产物：
  描述：

  3-甲基苯甲醛 在 rhodium(III) chloride 、 一氧化碳 、 碳酸氢铵 作用下， 以 甲醇 、 水 为溶剂， 160.0 ℃ 、5.07 MPa 条件下， 反应 22.0h， 以65%的产率得到三(3-甲基苄基)胺
  参考文献：
  名称：

  由羰基化合物，碳酸铵和一氧化碳作为还原剂一次合成对称的叔胺和仲胺

  摘要：

  已经开发了由醛和酮，碳酸铵作为氮源，一氧化碳作为还原剂的Rh催化一步和叔胺合成的叔胺和仲胺。脂肪醛和芳香醛可产生相应的叔对称胺，产率为69-83％。芳香族和脂肪族酮可产生相应的仲对称胺，产率为62-79％。

  DOI：

  10.1002/ejoc.201901175

文献信息

• Ruthenium-catalyzed Formation of Tertiary Amines from Nitriles and Alcohols
  作者：Saiwen Liu、Ru Chen、Guo-Jun Deng

  DOI：10.1246/cl.2011.489

  日期：2011.5.5

  A ruthenium-catalyzed tertiary-amine formation was developed using the borrowing hydrogen strategy. Various tertiary amines were obtained efficiently from nitriles and primary alcohols. Two possibl...

  使用借氢策略开发了钌催化的叔胺形成。从腈和伯醇中可以有效地获得各种叔胺。两种可能...
• The “Borrowing Hydrogen Strategy” by Supported Ruthenium Hydroxide Catalysts: Synthetic Scope of Symmetrically and Unsymmetrically Substituted Amines
  作者：Kazuya Yamaguchi、Jinling He、Takamichi Oishi、Noritaka Mizuno

  DOI：10.1002/chem.201000149

  日期：2010.6.25

  the N‐alkylation of ammonia (or its surrogates) and amines with “primary” alcohols. On the other hand, the N‐alkylation of ammonia surrogates (i.e., urea and NH4HCO3) with “secondary” alcohols selectively produced the corresponding symmetrically substituted “secondary” amines, even in the presence of excess amounts of alcohols, which is likely due to the steric hindrance of the secondary alcohols and/or

  易于制备的厌氧条件下，可以有效地促进氨（或其替代物，如尿素，NH 4 HCO 3和（NH 4）2 CO 3）和胺与醇（包括伯醇和仲醇）的N-烷基化反应。廉价的负载型氢氧化钌催化剂Ru（OH）x / TiO 2。氨（或其替代物）和胺与“伯”醇的N烷基化反应可以合成各种类型的对称和不对称取代的“叔”胺。另一方面，氨代用品（即尿素和NH 4）的N烷基化HCO 3）与“仲”醇选择性地产生相应的对称取代的“仲”胺，即使在存在过量的醇的情况下，这很可能是由于所产生的仲醇和/或仲胺的空间位阻所致。在有氧条件下，腈可以直接由醇和代理氨合成。观察到的当前N烷基化反应的催化本质上是非均相的，并且回收的催化剂可以重复使用而不会显着降低催化性能。当前的催化转化将通过连续N次进行烷基化反应，其中醇充当烷基化试剂。根据氘标记实验，建议在N烷基化反应期间形成二氢化钌。
• Homogeneous Hydrogenations of Nitriles Catalyzed by Rhenium Complexes
  作者：Kunjanpillai Rajesh、Balz Dudle、Olivier Blacque、Heinz Berke

  DOI：10.1002/adsc.201000867

  日期：2011.6

  Rhenium(I) nitrosyl complexes bearing large bite angle diphosphines efficiently catalyze the hydrogenation of nitriles to the corresponding symmetrical secondary amines.

  带有大咬合角二膦的（（I）亚硝酰基络合物可有效催化腈的氢化反应，形成相应的对称仲胺。
• One-Pot Synthesis of Symmetrical Tertiary and Secondary Amines from Carbonyl Compounds, Ammonium Carbonate and Carbon Monoxide as a Reductant
  作者：Karim Muratov、Oleg I. Afanasyev、Ekaterina Kuchuk、Sofiya Runikhina、Denis Chusov

  DOI：10.1002/ejoc.201901175

  日期：2019.10.17

  Rh‐catalyzed one‐step synthesis of tertiary and secondary amines from aldehydes and ketones, ammonium carbonate serving as nitrogen source, and carbon monoxide as a reducing agent has been developed. Aliphatic and aromatic aldehydes lead to the corresponding tertiary symmetrical amines in 69–83 % yields. Aromatic and aliphatic ketones lead to the corresponding secondary symmetrical amines which were

  已经开发了由醛和酮，碳酸铵作为氮源，一氧化碳作为还原剂的Rh催化一步和叔胺合成的叔胺和仲胺。脂肪醛和芳香醛可产生相应的叔对称胺，产率为69-83％。芳香族和脂肪族酮可产生相应的仲对称胺，产率为62-79％。
• Cyclone Mitigation, Resource Allocation and Post-disaster Reconstruction in South India: Lessons from Two Decades of Research
  作者：Peter Winchester

  DOI：10.1111/1467-7717.00129

  日期：2000.3

  This paper opens with a history of development and disaster‐prevention strategies in a cyclone‐prone area of the east coast of India and traces the evolution in the area of British and Indian governments' programmes and policy over a century. Research over the last 20 years has shown however that the programmes and policies have failed to balance economic growth with safety. Resources intended for the benefit of all have been diverted by alliances of powerful people to a small minority, and recent developments have reduced the physical protection of the area. The result is that increasing numbers of people are vulnerable to the effects of cyclones and floods. The findings suggest that the best way to reduce vulnerability is to improve the socio‐economic standing of the most vulnerable and for this to happen these people must have an assured income based on assets that will enable them to acquire social and economic credit‐worthiness within the local economy. This paper presents evidence that suggests that non‐governmental organisation (NGO)‐supported co‐operatives are the best way to achieve this through self‐help and self‐employment schemes. It also suggests that NGOs should be encouraged to take up environmentally and ecologically beneficial activities involving the poorest groups in the communities, in this way combining sustained self‐employment with environmental protection.