for the cyclopropanation of α,β-unsaturated carbonyl compounds and related systems is described which employs trimethylsulfoxonium iodide and an organic base in acetonitile to generate dimethylsulfoxonium methylide in situ; in addition, preliminary results are described in which activated alcohols are converted directly into cyclopropyl ketones by a one-pot tandem oxidation-cyclopropanation sequence
描述了一种用于α,β-不饱和羰基化合物
环丙烷化的新方法和相关系统,该方法采用
碘化三甲基亚砜和有机碱在
乙腈中原位生成甲基亚砜;此外,还描述了初步结果,其中活化的醇通过一锅串联氧化 -
环丙烷化序列直接转化为环丙基酮。