5-(4-methoxy-3-methyl-phenyl)-dihydro-furan-2-one | 77996-12-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-(4-methoxy-3-methyl-phenyl)-dihydro-furan-2-one
• 英文别名: 5-(4-Methoxy-3-methyl-phenyl)-dihydro-furan-2-on；5-(4-Methoxy-3-methylphenyl)oxolan-2-one；5-(4-methoxy-3-methylphenyl)oxolan-2-one
• CAS: 77996-12-4
• 化学式: C₁₂H₁₄O₃
• 分子量: 206.241
• InChiKey: GFGCUESEDCQYNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-甲基苯甲醚 在 Pd-BaSO₄ 、 三氯化铝 、 乙醇 、 硝基苯 作用下， 生成 5-(4-methoxy-3-methyl-phenyl)-dihydro-furan-2-one
  参考文献：
  名称：

  Synthetische Versuche in der Reihe der Antihelmintika

  摘要：

  DOI：

  10.1002/ardp.19342721017

文献信息

• Isolation and synthesis of two antiproliferative calamenene-type sesquiterpenoids from Sterculia tavia from the Madagascar Rain Forest
  作者：Yumin Dai、Liva Harinantenaina、Peggy J. Brodie、Martin W. Callmander、Sennen Randrianasolo、Etienne Rakotobe、Vincent E. Rasamison、David G.I. Kingston

  DOI：10.1016/j.bmc.2012.10.012

  日期：2012.12

  Investigation of the endemic Madagascan plant Sterculia taiva Baill. (Malvaceae) for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of two new bioactive calamenene-type sesquiterpenoids, named tavinin A (2) and epi-tavinin A (3) together with the known sesquiterpenoid mansonone G (1). The structures of the two new compounds were elucidated based on analysis of their 1D and 2D NMR spectra and mass spectrometric data, and were confirmed by de novo synthesis. The three isolated sesquiterpenoids (1-3) had modest antiproliferative activities against the A2780 ovarian cancer cell line, with IC50 values of 10.2, 5.5 and 6.7 mu M, respectively. (C) 2012 Elsevier Ltd. All rights reserved.
• Synthetische Versuche in der Reihe der Antihelmintika
  作者：K. W. Rosenmund、D. Schapiro

  DOI：10.1002/ardp.19342721017

  日期：——