3-(4-benzoylphenoxyl)propane-1,2-diol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(4-benzoylphenoxyl)propane-1,2-diol
• 英文别名: [4-(2,3-dihydroxy-propoxy)-phenyl]phenyl-methanone；(4-(2,3-Dihydroxypropoxy)phenyl)(phenyl)methanone；[4-(2,3-dihydroxypropoxy)phenyl]-phenylmethanone
• 化学式: C₁₆H₁₆O₄
• 分子量: 272.301
• InChiKey: VVJYBNKHWPNIJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  丙烯酸乙烯基乙氧基乙酯 、 3-(4-benzoylphenoxyl)propane-1,2-diol 在 3-吡啶磺酸 作用下， 反应 22.0h， 生成 2-[2-[1-[3-(4-Benzoylphenoxy)-2-[1-[2-(2-prop-2-enoyloxyethoxy)ethoxy]ethoxy]propoxy]ethoxy]ethoxy]ethyl prop-2-enoate
  参考文献：
  名称：

  [EN] SYNTHESIS OF ACETAL COMPOUNDS USING ZWITTERIONIC CATALYSTS
  [FR] SYNTHÈSE DE COMPOSÉS ACÉTAL À L'AIDE DE CATALYSEURS ZWITTERIONIQUES

  摘要：

  一种制备可选择性不对称缩醛化合物的方法，包括在带有至少一个碱性氮结构基团和至少一个磺酸基团的偶极催化剂存在下，将含有羟基的化合物与乙烯基醚化合物反应，但碱性氮和磺酸的摩尔比为1比1。

  公开号：

  WO2015062935A1
• 作为产物：
  描述：

  4-羟基-二苯甲酮 在 四乙基溴化铵 、 三氟乙酸 作用下， 以 水 、 1,2-二氯乙烷 为溶剂， 生成 3-(4-benzoylphenoxyl)propane-1,2-diol
  参考文献：
  名称：

  NOVEL POLYMERIC PHOTOINITIATORS AND PHOTOINITIATOR MONOMERS

  摘要：

  本发明提供了聚合物光引发剂，其为光引发剂单体与至少一种进一步单体的共聚物，以及作为这种聚合物光引发剂制备过程中的中间体的光引发剂单体。此外，还提供了通过在存在这种聚合物光引发剂的情况下，通过至少一种丙烯酸酯单体（Ac）的自由基聚合得到的聚丙烯酸酯。在光引发剂单体和聚合物光引发剂中，光引发剂基团、水解稳定连接物和两个可聚合功能基团被结合到光引发剂结构中。

  公开号：

  US20150148441A1

文献信息

• Benzophenone derivative, ultraviolet absorbent and external preparation
  申请人：Shiseido Co., Ltd.

  公开号：US05342610A1

  公开（公告）日：1994-08-30

  Benzophenone derivatives expressed by the following general expression (1): A(C--B).sub.n (1) wherein A in the above general expression (1) is a residual group obtained by removing one hydroxyl group from sugar or sugar alcohol, and B is a benzophenone group shown by the following general expression (2) ##STR1## wherein R.sub.1 through R.sub.10 each is expressed by hydrogen, hydroxyl group, an alkoxy group, or the aforesaid binder C, and at least one of them is the binder C. In the case of an alkoxy group, preferably the number of carbon atoms is 1 to 4. C is equivalent to --O--R-- (O is oxygen, R is a fatty chain, and the number of carbon atoms therein is preferably 1 to 4), or 1 mole of glycerin with one hydroxyl group therein bound to A and another hydroxyl group to B. The benzophenone derivatives according to the present invention have excellent capability to absorb ultraviolet rays as well as high compatibility with polar solvent. Also the external preparation for skin in which the benzophenone derivatives are mixed can be mixed in a polar base with wide availability for industrial purpose.

  以下是通式（1）所表示的苯基酮衍生物：A（C-B）n（1），其中在上述通式（1）中，A是从糖或糖醇中去除一个羟基后得到的残基基团，B是由以下通式（2）所示的苯基酮基团：##STR1## 其中R1至R10分别表示氢、羟基、烷氧基或上述结合剂C，其中至少有一个是结合剂C。在烷氧基的情况下，碳原子数最好为1至4。C相当于--O--R--（O为氧，R为脂肪链，其中碳原子数最好为1至4），或者1摩尔的甘油，其中一个羟基与A结合，另一个羟基与B结合。本发明的苯基酮衍生物具有优异的吸收紫外线的能力，以及与极性溶剂高度兼容的优点。同时，将苯基酮衍生物混合到皮肤外用制剂中，可以与具有广泛工业用途的极性基础混合。
• Polymeric photoinitiators and photoinitiator monomers
  申请人：Coloplast A/S

  公开号：US09296835B2

  公开（公告）日：2016-03-29

  The present invention provides polymeric photoinitiators being co-polymers of photoinitiator monomers and at least one further monomer, as well as photoinitiator monomers being intermediates in the preparation of such polymeric photoinitiators. Additionally, there is provided polyacrylate obtained by radical polymerization of at least one acrylate monomer (Ac) in the presence of such polymeric photoinitiators. In the photoinitiator monomers and polymeric photoinitiators, a photoinitiator moiety, a hydrolytic stable linker and two polymerizable functional groups are incorporated into the photoinitiator structure.

  本发明提供了聚合物光引发剂，其为光引发剂单体和至少一种其他单体的共聚物，以及作为制备这种聚合物光引发剂的中间体的光引发剂单体。此外，本发明还提供了在这种聚合物光引发剂存在下，在至少一种丙烯酸酯单体（Ac）的自由基聚合中获得的聚丙烯酸酯。在光引发剂单体和聚合物光引发剂中，将光引发剂基团、水解稳定连接器和两个可聚合的功能基团结合到光引发剂结构中。
• SYNTHESIS OF ACETAL COMPOUNDS
  申请人：AGFA GRAPHICS NV

  公开号：US20160237185A1

  公开（公告）日：2016-08-18

  A process for the preparation of optionally asymmetric acetal compounds includes reacting a compound containing a hydroxyl group with a vinylether compound in the presence of a zwitterionic catalyst including at least one basic nitrogen containing structural fragment and at least one sulfonic acid group in its structure, with the proviso that a molar ratio of the basic nitrogen to sulfonic acid is 1:1

  一种制备可选非对称缩醛化合物的方法，包括在带有至少一个碱性氮结构片段和至少一个磺酸基团的中性离子催化剂存在下，将含有羟基的化合物与乙烯醚化合物反应，但碱性氮与磺酸的摩尔比为1:1。
• Polymerizable photoinitiators and radiation curable compositions
  申请人：AGFA NV

  公开号：EP2199273B1

  公开（公告）日：2018-02-21
• Lipase-catalysed resolution of 3-(aryloxy)-1,2-propanediol derivatives — Towards an improved active site model of Pseudomonas cepacia lipase (amano PS)
  作者：Fritz Theil、Karin Lemke、Sibylle Ballschuh、Annamarie Kunath、Hans Schick

  DOI：10.1016/0957-4166(95)00166-m

  日期：1995.6

  A variety of 3-(aryloxy)-1,2-propanediol derivatives with different substituents on the aromatic ring or at the primary hydroxy group were used as substrates in a kinetic resolution by transesterification with vinyl acetate catalysed by lipase from Pseudomonas cepacia (Amano PS). Derivatives with substituents in the para-position of the aromatic ring were accepted as substrates and resolved with high enantioselectivity. The corresponding derivatives with substituents in the ortho-position were much worse substrates for lipase PS or even non-substrates if the substituent was sufficiently space-filling as found for the tert-butyl, phenyl, benzyl or benzoyl residue. Otherwise, if the primary hydroxy group was substituted by unbranched long-chain acyl residues very good substrates were resulting. In contrast, derivatives with sterically crowded residues at the primary hydroxy group such as the pivaloyl, tert-butyldimethylsilyl, methanesulfonyl, para-toluenesulfonyl or trityl groups were nonsubstrates for lipase PS.