3-(hydrazinecarbonyl)pyrazine 1-oxide | 769-98-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-(hydrazinecarbonyl)pyrazine 1-oxide
• 英文别名: pyrazine-N-oxide-3-carbohydrazide；4-oxy-pyrazine-2-carboxylic acid hydrazide；Pyrazin-2-carbonsaeure-hydrazid-4-N-oxid；Pyrazin-4-oxid-2-carbonsaeurehydrazid
• CAS: 769-98-2
• 化学式: C₅H₆N₄O₂
• mdl: MFCD00233245
• 分子量: 154.128
• InChiKey: XNLZIIKVJWNPLY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.78
• 重原子数：
  11.0
• 可旋转键数：
  1.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  94.95
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  环己基异硫氰酸脂 、 3-(hydrazinecarbonyl)pyrazine 1-oxide 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.25h， 以88%的产率得到3-(2-(cyclohexylcarbamothioyl)hydrazinecarbonyl)pyrazine 1-oxide
  参考文献：
  名称：

  Synthesis and Tuberculostatic Activity of Novel 1,2,4-Triazoles Obtained from Heterocyclic Carbohydrazides

  摘要：

  The novel 1,2,4-triazole derivatives have been synthesized by a few different pathways. Heterocyclic carbohydrazides were used to obtain monoesters of hydrazine acids (1-6), thiosemicarbazide derivatives (7-17), and finaly 1,2,4-triazole-5-thiones (18-38). Carbohydrazides were also cyclized with methyl carbamodithioates in the presence of DBU giving 1,2,4-triazole-5-thiones (18, 19, 39-47). Two of final products (39, 40) were undergone alkylation in alkaline solution to appropriate sulfides (48-53). Then methylsulfides (48, 49) were oxidized with peroxyacetic acid to sulfoxides (54, 55). The obtained compounds were tested in vitro towards Mycobacterium tuberculosis.

  DOI：

  10.3987/com-09-11888

文献信息

• Tuning the dynamic magnetic behaviour and proton conductivity <i>via</i> water-induced reversible single-crystal to single-crystal structural transformation
  作者：Xiao-Qin Ji、Rong Sun、Jin Xiong、Hao-Ling Sun、Song Gao

  DOI：10.1039/d1tc03920b

  日期：——

  A rare dysprosium layered complex undergoing humidity induced single-crystal to single-crystal transformation and the synergetic switch of the dynamic magnetic behaviour and proton conductivity has been successfully constructed.

  一种罕见的镝层状配合物，在湿度诱导下成功地进行了单晶到单晶转化，并且动态磁性行为和质子导电性的协同开关得到了构建。
• Enhancing the magnetic performance of pyrazine-<i>N</i>-oxide bridged dysprosium chains through controlled variation of ligand coordination modes
  作者：Xiao-Qin Ji、Jin Xiong、Rong Sun、Fang Ma、Hao-Ling Sun、Yi-Quan Zhang、Song Gao

  DOI：10.1039/d1dt00635e

  日期：——

  dysprosium chain complexes, namely, [Dy2(L)2Cl2(CH3OH)3]n·nCH3OH (1) and [Dy(L)Cl(DMF)]n (2) (H2L = N‘-(5-bromo-2-hydroxybenzylidene)pyrazine-N-oxide-carbohydrazide), can be successfully manipulated using an appropriate bridging ligand design. Both complexes contain similar dimeric units bridged by two alkoxido oxygens from an L2− ligand, but extended by its pyrazine-N-oxide group exhibiting two distinct

  尽管以可控的方式组装超顺磁性单元对于分子纳米磁体的未来应用至关重要，但是在实现这些单元的定向组装的同时优化其磁性能仍然是一个艰巨的挑战。在这里，我们演示如何组装两个two链络合物，即[Dy 2（L）2 Cl 2（CH 3 OH）3 ] n · n CH 3 OH（1）和[Dy（L）Cl（DMF） ] n（2）（H 2 L = N '-（5-溴-2-羟基亚苄基）吡嗪-N-氧化物-碳酰肼）可以使用适当的桥连配体设计成功进行操作。两种络合物均包含相似的二聚体单元，所述二聚体单元由来自L 2-配体的两个烷氧基氧桥接，但被其吡嗪-N-氧化物基团延伸，表现出两种不同的配位模式，即分别为单和双吡嗪-N-氧化物桥。磁性研究表明，两种配合物在零直流磁场下均表现出典型的慢磁弛豫；然而，各向异性屏障和在2 K代表复合物中的矫顽场2是两倍该的1。进一步的理论研究表明，从单个吡嗪-N切换配位模式氧化桥到双桥可以同时
• Synthesis, Characterization, and Tuberculostatic Activity of Novel Heterocyclic Compounds Derived from Dimethyl Heteroaroylcarbonohydrazonodithioates
  作者：Katarzyna Gobis、Henryk Foks、Ewa Augustynowicz-Kopeć、Agnieszka Napiórkowska

  DOI：10.3987/com-12-12524

  日期：——

  A series of dimethyl heteroaroylcarbonohydrazonodithioates (1-5) has been synthesized from various heterocyclic carbohydrazides. N'-(Cycloalkyldiamin-2-ylidene)heteroaroylhydrazides (9-20) were obtained by the substitution of dimethyl heteroaroylcarbonohydrazonodithioates with respective diamines in EtOH or dioxane. In water the substitution was followed by cyclization to 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrimidines (21-23). The compounds obtained were tested in vitro towards M tuberculosis standard strain (H(37)Rv) and two "wild" strains, susceptible (Spec. 192) and resistant (Spec. 210). MIC values for all the compounds tested were within 25-100 mu g/mL which indicated their activity lower than reference drugs used (INH, PZA).