2-氟-5-甲基二苯胺 | 155310-23-9

• 物质功能分类: 医药中间体 - 二苯胺类中间体
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-氟-5-甲基二苯胺
• 英文名称: 2-fluoro-5-methyl-diphenylamine
• 英文别名: 2-fluoro-5-methyldiphenylamine；2-Fluoro-5-methyl-N-phenylaniline
• CAS: 155310-23-9
• 化学式: C₁₃H₁₂FN
• mdl: MFCD11975431
• 分子量: 201.243
• InChiKey: FSRYWFORMDRXIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.076
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  2

SDS

2-Fluoro-5-methyldiphenylamine
SAFETY DATA SHEET

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Section 1. IDENTIFICATION
Product name: 2-Fluoro-5-methyldiphenylamine

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Section 2. HAZARDS IDENTIFICATION
GHS classification
PHYSICAL HAZARDS Not classified
HEALTH HAZARDS
Skin corrosion/irritation Category 2
Category 2A
Serious eye damage/eye irritation
ENVIRONMENTAL HAZARDS Not classified
GHS label elements, including precautionary statements
Pictograms or hazard symbols
Signal word Warning
Hazard statements Causes skin irritation
Causes serious eye irritation
Precautionary statements:
Wash hands thoroughly after handling.
[Prevention]
Wear protective gloves/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses,
[Response]
if present and easy to do. Continue rinsing.
If eye irritation persists: Get medical advice/attention.
IF ON SKIN: Gently wash with plenty of soap and water.
If skin irritation occurs: Get medical advice/attention.
Take off contaminated clothing and wash before reuse.

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture: Substance
Components: 2-Fluoro-5-methyldiphenylamine
Percent: >97.0%(GC)
CAS Number: 155310-23-9
Chemical Formula: C13H12FN

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Section 4. FIRST AID MEASURES
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Get medical advice/attention if you feel unwell.
2-Fluoro-5-methyldiphenylamine

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Section 4. FIRST AID MEASURES
Skin contact: Remove/Take off immediately all contaminated clothing. Gently wash with plenty of
soap and water. If skin irritation or rash occurs: Get medical advice/attention.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention.
Ingestion: Get medical advice/attention if you feel unwell. Rinse mouth.
A rescuer should wear personal protective equipment, such as rubber gloves and air-
Protection of first-aiders:
tight goggles.

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Section 5. FIRE-FIGHTING MEASURES
Suitable extinguishing Dry chemical, foam, water spray, carbon dioxide.
media:
Unsuitable extinguishing Solid streams of water
media:
Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to
from the chemical: generate poisonous fume.
Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Remove movable
containers if safe to do so.
Special protective When extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:

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Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, Use personal protective equipment. Keep people away from and upwind of spill/leak.
protective equipment and Ensure adequate ventilation. Entry to non-involved personnel should be controlled
emergency procedures: around the leakage area by roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Absorb spilled material in a suitable absorbent (e.g. rag, dry sand, earth, saw-dust).
containment and cleaning In case of large amount of spillage, contain a spill by bunding. Adhered or collected
up: material should be promptly disposed of, in accordance with appropriate laws and
regulations.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Technical measures: Handling is performed in a well ventilated place. Wear suitable protective equipment.
Prevent generation of vapour or mist. Wash hands and face thoroughly after
handling.
Use a ventilation, local exhaust if vapour or aerosol will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Conditions for safe storage, including any
incompatibilities
Storage conditions: Keep container tightly closed. Store in a cool and dark place.
Store away from incompatible materials such as oxidizing agents.
Comply with laws.
Packaging material:

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Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering controls: Install a closed system or local exhaust as possible so that workers should not be
exposed directly. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Vapor respirator. Follow local and national regulations.
Hand protection: Protective gloves.
Safety glasses. A face-shield, if the situation requires.
Eye protection:
Skin and body protection: Protective clothing. Protective boots, if the situation requires.
2-Fluoro-5-methyldiphenylamine

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C): Liquid
Form: Clear
Yellow - Deep reddish yellow
Colour:
Odour: No data available
pH: No data available
Melting point/freezing point:No data available
No data available
Boiling point/range:
Flash point: No data available
Flammability or explosive
limits:
No data available
Lower:
Upper: No data available
1.14
Relative density:
Solubility(ies):
No data available
[Water]
[Other solvents] No data available

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Section 10. STABILITY AND REACTIVITY
Chemical stability: Stable under proper conditions.
Possibility of hazardous No special reactivity has been reported.
reactions:
Incompatible materials: Oxidizing agents
Hazardous decomposition Carbon monoxide, Carbon dioxide, Nitrogen oxides (NOx), Hydrogen fluoride
products:

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Section 11. TOXICOLOGICAL INFORMATION
Acute Toxicity: No data available
Skin corrosion/irritation: No data available
Serious eye No data available
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
IARC = No data available
No data available
NTP =
Reproductive toxicity: No data available

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Section 12. ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: No data available
Crustacea: No data available
Algae: No data available
Persistence / degradability: No data available
Bioaccumulative No data available
potential(BCF):
Mobility in soil
Log Pow: No data available
Soil adsorption (Koc): No data available
Henry's Law No data available
constant(PaM3/mol):

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Section 13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to burn in a chemical
incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when
disposing of the substance.
2-Fluoro-5-methyldiphenylamine

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Section 14. TRANSPORT INFORMATION
Hazards Class: Does not correspond to the classification standard of the United Nations
UN-No: Not listed

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Section 15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
loading and unloading were prescribed.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2-氟-5-甲基二苯胺 、 lithium diisopropylphosphide 在 正丁基锂 、 乙醇 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 170.0h， 生成 [MePN]Li
  参考文献：
  名称：

  Emissive monomeric metal complexes

  摘要：

  提供具有改进荧光性能的单聚金属配合物。在一个实施例中，单聚金属配合物由公式[PN]M(L)2表示。PN是一种酰胺膦配体，M可以是任何能够展现荧光性能的金属，例如，d10金属。L可以是三膦。另外，第二个PN配体或DPPE可以替代两个L配体的位置。

  公开号：

  US20080064893A1
• 作为产物：
  描述：

  2-氟-5-甲基苯胺 生成 2-氟-5-甲基二苯胺
  参考文献：
  名称：

  Process for producing diphenylamines or N,N'-diphenyl-phenylenediamines

  摘要：

  二苯胺或N，N'-二苯基-苯二胺可以通过将苯胺或苯二胺与过量的苯酚（每摩尔苯胺或苯二胺4至20摩尔的量）在氢转移催化剂和对应于该苯酚的环己酮的存在下热反应来获得。反应中使用的过量苯酚在反应系统中发生还原反应形成环己酮，然后与苯胺或苯二胺发生酰胺反应从而被消耗。酰胺通过脱氢反应形成预期产物，此时产生的氢还原苯酚形成环己酮。因此，反应中存在的过量苯酚在系统中成为溶剂、环己酮的起始原料，以及在形成预期产物时作为副产物形成的氢的受体。因此，可以从苯胺和苯二胺中高选择性地获得预期产物。这种发明的工艺是一种有利的工业生产尤其是核取代二苯胺的过程。

  公开号：

  US04804783A1

文献信息

• EMISSIVE MONOMERIC METAL COMPLEXES
  申请人：Peters Jonas C.

  公开号：US20100217023A1

  公开（公告）日：2010-08-26

  Monomeric metal complexes having improved luminescence properties are provided. In one embodiment, a monomeric metal complex is represented by the formula [PN]M(L) 2 . PN is an amidophosphine ligand, and M may be any metal capable of exhibiting luminescent properties, for example, a d 10 metal. L may be a tertiary phosphine. Alternatively, a second PN ligand or DPPE may take the place of both L ligands.
• US4804783A
  申请人：——

  公开号：US4804783A

  公开（公告）日：1989-02-14
• US4871875A
  申请人：——

  公开号：US4871875A

  公开（公告）日：1989-10-03
• US4952731A
  申请人：——

  公开号：US4952731A

  公开（公告）日：1990-08-28
• US7683183B2
  申请人：——

  公开号：US7683183B2

  公开（公告）日：2010-03-23