(R)-1-[2-[2,3-bis-(tetradecyloxy)propoxy]ethyl]dimethylamine | 869802-94-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: (R)-1-[2-[2,3-bis-(tetradecyloxy)propoxy]ethyl]dimethylamine
• 英文别名: 2-[(2R)-2,3-di(tetradecoxy)propoxy]-N,N-dimethylethanamine
• CAS: 869802-94-8
• 化学式: C₃₅H₇₃NO₃
• 分子量: 555.97
• InChiKey: VNJGPGBSFDJZIM-PGUFJCEWSA-N

物化性质

• 沸点：
  595.9±40.0 °C(Predicted)
• 密度：
  0.878±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  13.2
• 重原子数：
  39
• 可旋转键数：
  34
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  30.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (R)-1-[2-[2,3-bis-(tetradecyloxy)propoxy]ethyl]dimethylamine 、 1,3-二溴-2-丙醇 以 乙醇 为溶剂， 反应 168.0h， 以74%的产率得到
  参考文献：
  名称：

  Synthesis of cationic cardiolipin analogues

  摘要：

  An approach was developed to synthesize a new class of cationic cardiolipin analogues containing two quaternary ammonium groups with tetra alkyl groups retaining "glycerol" moiety, the central core of the molecule. Cationic cardiolipin analogues were modified via introduction of either two or four oxyethylene groups to enhance the solubility in polar solvents. These newly synthesized cationic cardiolipin analogues can be applied to a broad range of drug delivery systems such as transfection reagents. (c) 2005 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.bioorg.2005.06.001
• 作为产物：
  描述：

  1,2-di-O-tetradecyl-sn-glycerol 在 盐酸 、 四溴化碳 、 sodium hydride 、 三苯基膦 作用下， 以 甲醇 、 乙醚 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 115.0h， 生成 (R)-1-[2-[2,3-bis-(tetradecyloxy)propoxy]ethyl]dimethylamine
  参考文献：
  名称：

  Synthesis of cationic cardiolipin analogues

  摘要：

  An approach was developed to synthesize a new class of cationic cardiolipin analogues containing two quaternary ammonium groups with tetra alkyl groups retaining "glycerol" moiety, the central core of the molecule. Cationic cardiolipin analogues were modified via introduction of either two or four oxyethylene groups to enhance the solubility in polar solvents. These newly synthesized cationic cardiolipin analogues can be applied to a broad range of drug delivery systems such as transfection reagents. (c) 2005 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.bioorg.2005.06.001

文献信息

• Cationic cardiolipin analoges and its use thereof
  申请人：Ahmad U. Moghis

  公开号：US20050277611A1

  公开（公告）日：2005-12-15

  The invention provides cationic cardiolipin compounds, and methods for synthesizing and using them in liposomal formulation, gene transfection, etc. In particular, the invention provides liposomes comprising cationic cardiolipin analog, pharmaceutical compositions comprising cationic cardiolipin analogs, and methods of using such liposomes and compositions, in delivering active pharmaceutical agents to treat human and animal diseases and/or in diagnostic assays.

  本发明提供了阳离子心磷脂化合物以及其合成和在脂质体制剂、基因转染等方面的使用方法。特别地，本发明提供了含阳离子心磷脂类似物的脂质体、含阳离子心磷脂类似物的药物组合物以及使用这些脂质体和组合物的方法，用于传递活性药物治疗人类和动物疾病和/或诊断测定。
• CATIONIC CARDIOLIPIN ANALOGS AND USE THEREOF
  申请人：Neopharm, Inc.

  公开号：EP1558562A1

  公开（公告）日：2005-08-03
• [EN] CATIONIC CARDIOLIPIN ANALOGS AND USE THEREOF<br/>[FR] ANALOGUES DE CARDIOLIPINE CATIONIQUES ET UTILISATION DE CEUX-CI
  申请人：NEOPHARM INC

  公开号：WO2004035523A1

  公开（公告）日：2004-04-29

  The invention provides cationic cardiolipin compounds, and methods for synthesizing and using them in liposomal formulation, gene transfection, etc. In particular, the invention provides liposomes comprising cationic cardiolipin analog, pharmaceutical compositions comprising cationic cardiolipin analogs, and methods of using such liposomes and compositions, in delivering active pharmaceutical agents to treat human and animal diseases and/or in diagnostic assays.
• Synthesis of cationic cardiolipin analogues
  作者：Krishnudu Kasireddy、Shoukath M. Ali、Moghis U. Ahmad、Sreeti Choudhury、Pei-Yu Chien、Saifuddin Sheikh、Imran Ahmad

  DOI：10.1016/j.bioorg.2005.06.001

  日期：2005.10

  An approach was developed to synthesize a new class of cationic cardiolipin analogues containing two quaternary ammonium groups with tetra alkyl groups retaining "glycerol" moiety, the central core of the molecule. Cationic cardiolipin analogues were modified via introduction of either two or four oxyethylene groups to enhance the solubility in polar solvents. These newly synthesized cationic cardiolipin analogues can be applied to a broad range of drug delivery systems such as transfection reagents. (c) 2005 Elsevier Inc. All rights reserved.